Biphasic parameter determination of sheep articular cartilage from stress relaxation data using an optimized 3D FE-based method
Mechanical characteristics of hard and soft tissues are central features for the quantitative description of tissue properties. In this study, we present a biphasic 3D-FE-based method to determine the biomechanical properties of sheep stifle joint articular cartilage (load-bearing area of the medial...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2023-09-01
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| Series: | Current Directions in Biomedical Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/cdbme-2023-1096 |
| _version_ | 1797646289210441728 |
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| author | Reuter Thomas Horbert Victoria Kinne Raimund Hurschler Christof |
| author_facet | Reuter Thomas Horbert Victoria Kinne Raimund Hurschler Christof |
| author_sort | Reuter Thomas |
| collection | DOAJ |
| description | Mechanical characteristics of hard and soft tissues are central features for the quantitative description of tissue properties. In this study, we present a biphasic 3D-FE-based method to determine the biomechanical properties of sheep stifle joint articular cartilage (load-bearing area of the medial and lateral femur condyle, n = 28) from stress relaxation indentation tests (s = 0.1 mm, t = 180 s). The FE-model computation was optimized by exploiting the axial symmetry and mesh resolution. Parameters were determined using the Levenberg-Marquardt-algorithm. Results showed significant differences between the biomechanical parameters of the lateral (n = 11) and medial (n = 17) femur condyle of the sheep stifle joint articular cartilage. R² of the fit results varied between 0.91 and 0.99. Overall values for the Young’s modulus were 1.316 ± 0.778 MPa, for the Poisson’s ratio 0.106 ± 0.088 and for the permeability 0.008 ± 0.004 mm4/Ns. Future work will focus on studying the influence of experimental settings on the results obtained with the biphasic 3D-FE-model. |
| first_indexed | 2024-03-11T15:00:28Z |
| format | Article |
| id | doaj.art-1cd10f2956894418ae9fe5c759e45dc4 |
| institution | Directory Open Access Journal |
| issn | 2364-5504 |
| language | English |
| last_indexed | 2024-03-11T15:00:28Z |
| publishDate | 2023-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Current Directions in Biomedical Engineering |
| spelling | doaj.art-1cd10f2956894418ae9fe5c759e45dc42023-10-30T07:58:12ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042023-09-019138338610.1515/cdbme-2023-1096Biphasic parameter determination of sheep articular cartilage from stress relaxation data using an optimized 3D FE-based methodReuter Thomas0Horbert Victoria1Kinne Raimund2Hurschler Christof3ICM-Institut Chemnitzer Maschinen- und Anlagenbau e.V., Otto-Schmerbach- Str. 19, 09117Chemnitz, GermanyExperimental Rheumatology Unit, Orthopedic Professorship, Jena University Hospital, Waldkliniken Eisenberg GmbH, 07607Eisenberg, GermanyExperimental Rheumatology Unit, Orthopedic Professorship, Jena University Hospital, Waldkliniken Eisenberg GmbH, 07607Eisenberg, GermanyLaboratory for Biomechanics und Biomaterials, 30625Hannover, GermanyMechanical characteristics of hard and soft tissues are central features for the quantitative description of tissue properties. In this study, we present a biphasic 3D-FE-based method to determine the biomechanical properties of sheep stifle joint articular cartilage (load-bearing area of the medial and lateral femur condyle, n = 28) from stress relaxation indentation tests (s = 0.1 mm, t = 180 s). The FE-model computation was optimized by exploiting the axial symmetry and mesh resolution. Parameters were determined using the Levenberg-Marquardt-algorithm. Results showed significant differences between the biomechanical parameters of the lateral (n = 11) and medial (n = 17) femur condyle of the sheep stifle joint articular cartilage. R² of the fit results varied between 0.91 and 0.99. Overall values for the Young’s modulus were 1.316 ± 0.778 MPa, for the Poisson’s ratio 0.106 ± 0.088 and for the permeability 0.008 ± 0.004 mm4/Ns. Future work will focus on studying the influence of experimental settings on the results obtained with the biphasic 3D-FE-model.https://doi.org/10.1515/cdbme-2023-1096articular cartilagefe-modellingstress relaxationindentationparameter identificationbiphasic theory |
| spellingShingle | Reuter Thomas Horbert Victoria Kinne Raimund Hurschler Christof Biphasic parameter determination of sheep articular cartilage from stress relaxation data using an optimized 3D FE-based method Current Directions in Biomedical Engineering articular cartilage fe-modelling stress relaxation indentation parameter identification biphasic theory |
| title | Biphasic parameter determination of sheep articular cartilage from stress relaxation data using an optimized 3D FE-based method |
| title_full | Biphasic parameter determination of sheep articular cartilage from stress relaxation data using an optimized 3D FE-based method |
| title_fullStr | Biphasic parameter determination of sheep articular cartilage from stress relaxation data using an optimized 3D FE-based method |
| title_full_unstemmed | Biphasic parameter determination of sheep articular cartilage from stress relaxation data using an optimized 3D FE-based method |
| title_short | Biphasic parameter determination of sheep articular cartilage from stress relaxation data using an optimized 3D FE-based method |
| title_sort | biphasic parameter determination of sheep articular cartilage from stress relaxation data using an optimized 3d fe based method |
| topic | articular cartilage fe-modelling stress relaxation indentation parameter identification biphasic theory |
| url | https://doi.org/10.1515/cdbme-2023-1096 |
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