Antiretroviral resistance in HIV-1 patients at a tertiary medical institute in Saudi Arabia: a retrospective study and analysis
Abstract Background Since the early 90’s antiretroviral drugs have been available at King Faisal Specialist Hospital and Research Centre (KFSH&RC), a referral hospital in Riyadh, Saudi Arabia, for the treatment of both adults and children infected with HIV-1. However, up to date, there are no ge...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-08-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12879-018-3339-7 |
| _version_ | 1819206090846371840 |
|---|---|
| author | Maha Al-Mozaini Tahani Alrahbeni Reem Al-Mograbi Abdulrahman Alrajhi |
| author_facet | Maha Al-Mozaini Tahani Alrahbeni Reem Al-Mograbi Abdulrahman Alrajhi |
| author_sort | Maha Al-Mozaini |
| collection | DOAJ |
| description | Abstract Background Since the early 90’s antiretroviral drugs have been available at King Faisal Specialist Hospital and Research Centre (KFSH&RC), a referral hospital in Riyadh, Saudi Arabia, for the treatment of both adults and children infected with HIV-1. However, up to date, there are no genetic profiling data for the resistance-causing mutations in HIV-1 virus in patients on antiretroviral drugs therapy. This paper presents an initial report and a profiling survey of drug resistance-associated mutations of 103 HIV-1 patients seen at KFSH&RC. Methods This is a retrospective study on Patients treated at KFSH&RC since 2003 up to 2016. The analysis was done on the drug resistance mutations profiles of 103 patients who were undergoing highly active antiretroviral therapy protocols. Results Our analysis shows that the drug resistance mutations reported in our treatment cohort of HIV-infected adults patients is similar what is internationally reported to some extent. Additionally, we have identified novel drug resistance causing mutations. Furthermore, different profile of drug resistance causing mutations was also observed. Conclusion Patients showed both similar and new drug resistant causing mutations, early identification of these mutations is crucial to guide and avoid failure future therapy. |
| first_indexed | 2024-12-23T05:02:05Z |
| format | Article |
| id | doaj.art-1cd2612f04364be6816a9e77c5077c38 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-23T05:02:05Z |
| publishDate | 2018-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-1cd2612f04364be6816a9e77c5077c382022-12-21T17:59:11ZengBMCBMC Infectious Diseases1471-23342018-08-0118111010.1186/s12879-018-3339-7Antiretroviral resistance in HIV-1 patients at a tertiary medical institute in Saudi Arabia: a retrospective study and analysisMaha Al-Mozaini0Tahani Alrahbeni1Reem Al-Mograbi2Abdulrahman Alrajhi3Immunocompromised Host Research, Department of Infection and Immunity, The Research Centre, King Faisal Specialist Hospital and Research CentreRiyadh Colleges of Dentistry and PharmacyDepartment of Medicine, King Faisal Specialist Hospital and Research CentreDepartment of Medicine, King Faisal Specialist Hospital and Research CentreAbstract Background Since the early 90’s antiretroviral drugs have been available at King Faisal Specialist Hospital and Research Centre (KFSH&RC), a referral hospital in Riyadh, Saudi Arabia, for the treatment of both adults and children infected with HIV-1. However, up to date, there are no genetic profiling data for the resistance-causing mutations in HIV-1 virus in patients on antiretroviral drugs therapy. This paper presents an initial report and a profiling survey of drug resistance-associated mutations of 103 HIV-1 patients seen at KFSH&RC. Methods This is a retrospective study on Patients treated at KFSH&RC since 2003 up to 2016. The analysis was done on the drug resistance mutations profiles of 103 patients who were undergoing highly active antiretroviral therapy protocols. Results Our analysis shows that the drug resistance mutations reported in our treatment cohort of HIV-infected adults patients is similar what is internationally reported to some extent. Additionally, we have identified novel drug resistance causing mutations. Furthermore, different profile of drug resistance causing mutations was also observed. Conclusion Patients showed both similar and new drug resistant causing mutations, early identification of these mutations is crucial to guide and avoid failure future therapy.http://link.springer.com/article/10.1186/s12879-018-3339-7HIV resistanceAntiretroviral therapySaudi Arabia |
| spellingShingle | Maha Al-Mozaini Tahani Alrahbeni Reem Al-Mograbi Abdulrahman Alrajhi Antiretroviral resistance in HIV-1 patients at a tertiary medical institute in Saudi Arabia: a retrospective study and analysis BMC Infectious Diseases HIV resistance Antiretroviral therapy Saudi Arabia |
| title | Antiretroviral resistance in HIV-1 patients at a tertiary medical institute in Saudi Arabia: a retrospective study and analysis |
| title_full | Antiretroviral resistance in HIV-1 patients at a tertiary medical institute in Saudi Arabia: a retrospective study and analysis |
| title_fullStr | Antiretroviral resistance in HIV-1 patients at a tertiary medical institute in Saudi Arabia: a retrospective study and analysis |
| title_full_unstemmed | Antiretroviral resistance in HIV-1 patients at a tertiary medical institute in Saudi Arabia: a retrospective study and analysis |
| title_short | Antiretroviral resistance in HIV-1 patients at a tertiary medical institute in Saudi Arabia: a retrospective study and analysis |
| title_sort | antiretroviral resistance in hiv 1 patients at a tertiary medical institute in saudi arabia a retrospective study and analysis |
| topic | HIV resistance Antiretroviral therapy Saudi Arabia |
| url | http://link.springer.com/article/10.1186/s12879-018-3339-7 |
| work_keys_str_mv | AT mahaalmozaini antiretroviralresistanceinhiv1patientsatatertiarymedicalinstituteinsaudiarabiaaretrospectivestudyandanalysis AT tahanialrahbeni antiretroviralresistanceinhiv1patientsatatertiarymedicalinstituteinsaudiarabiaaretrospectivestudyandanalysis AT reemalmograbi antiretroviralresistanceinhiv1patientsatatertiarymedicalinstituteinsaudiarabiaaretrospectivestudyandanalysis AT abdulrahmanalrajhi antiretroviralresistanceinhiv1patientsatatertiarymedicalinstituteinsaudiarabiaaretrospectivestudyandanalysis |