Triggering Innate Immune Receptors as New Therapies in Alzheimer’s Disease and Multiple Sclerosis
Multiple sclerosis and Alzheimer’s disease are two complex neurodegenerative diseases involving the immune system. So far, available treatments provide at best mild improvements to patients’ conditions. For decades now, a new set of molecules have been used to modulate and regulate the innate immuni...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/8/2164 |
| _version_ | 1827685552981278720 |
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| author | Pierre-Alexandre Piec Vincent Pons Serge Rivest |
| author_facet | Pierre-Alexandre Piec Vincent Pons Serge Rivest |
| author_sort | Pierre-Alexandre Piec |
| collection | DOAJ |
| description | Multiple sclerosis and Alzheimer’s disease are two complex neurodegenerative diseases involving the immune system. So far, available treatments provide at best mild improvements to patients’ conditions. For decades now, a new set of molecules have been used to modulate and regulate the innate immunity in these pathologies. Most studies have been carried out in rodents and some of them have reported tremendous beneficial effects on the disease course. The modulation of innate immune cells is of great interest since it provides new hope for patients. In this review, we will briefly overview the therapeutic potential of some molecules and receptors in multiple sclerosis and Alzheimer’s disease and how they could be used to exploit new therapeutic avenues. |
| first_indexed | 2024-03-10T08:54:16Z |
| format | Article |
| id | doaj.art-1cd3363cbbe54358a5e91e0218294fc8 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T08:54:16Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-1cd3363cbbe54358a5e91e0218294fc82023-11-22T07:12:39ZengMDPI AGCells2073-44092021-08-01108216410.3390/cells10082164Triggering Innate Immune Receptors as New Therapies in Alzheimer’s Disease and Multiple SclerosisPierre-Alexandre Piec0Vincent Pons1Serge Rivest2Neuroscience Laboratory, CHU de Québec Research Center, Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Boul., Québec, QC G1V 4G2, CanadaNeuroscience Laboratory, CHU de Québec Research Center, Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Boul., Québec, QC G1V 4G2, CanadaNeuroscience Laboratory, CHU de Québec Research Center, Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Boul., Québec, QC G1V 4G2, CanadaMultiple sclerosis and Alzheimer’s disease are two complex neurodegenerative diseases involving the immune system. So far, available treatments provide at best mild improvements to patients’ conditions. For decades now, a new set of molecules have been used to modulate and regulate the innate immunity in these pathologies. Most studies have been carried out in rodents and some of them have reported tremendous beneficial effects on the disease course. The modulation of innate immune cells is of great interest since it provides new hope for patients. In this review, we will briefly overview the therapeutic potential of some molecules and receptors in multiple sclerosis and Alzheimer’s disease and how they could be used to exploit new therapeutic avenues.https://www.mdpi.com/2073-4409/10/8/2164monocytesmicrogliaamyloidinnate immunityToll-like receptorNOD2 |
| spellingShingle | Pierre-Alexandre Piec Vincent Pons Serge Rivest Triggering Innate Immune Receptors as New Therapies in Alzheimer’s Disease and Multiple Sclerosis Cells monocytes microglia amyloid innate immunity Toll-like receptor NOD2 |
| title | Triggering Innate Immune Receptors as New Therapies in Alzheimer’s Disease and Multiple Sclerosis |
| title_full | Triggering Innate Immune Receptors as New Therapies in Alzheimer’s Disease and Multiple Sclerosis |
| title_fullStr | Triggering Innate Immune Receptors as New Therapies in Alzheimer’s Disease and Multiple Sclerosis |
| title_full_unstemmed | Triggering Innate Immune Receptors as New Therapies in Alzheimer’s Disease and Multiple Sclerosis |
| title_short | Triggering Innate Immune Receptors as New Therapies in Alzheimer’s Disease and Multiple Sclerosis |
| title_sort | triggering innate immune receptors as new therapies in alzheimer s disease and multiple sclerosis |
| topic | monocytes microglia amyloid innate immunity Toll-like receptor NOD2 |
| url | https://www.mdpi.com/2073-4409/10/8/2164 |
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