Therapeutic effect of Sinapic acid in aluminium chloride induced dementia of Alzheimer's type in rats
Objective: To evaluate the effect of sinapic acid against Aluminium chloride-induced dementia of Alzheimer's disease (AD) type in rat.Methods: The study was designed to induce dementia by chronic exposure of aluminium chloride at a dose of 175 mg/kg, p.o. for a period of 25 days in rats and the...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Journal of Acute Disease |
| Subjects: | |
| Online Access: | http://www.jadweb.org/article.asp?issn=2221-6189;year=2017;volume=6;issue=4;spage=154;epage=162;aulast=Bais |
| _version_ | 1818683884633587712 |
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| author | Souravh Bais Renu Kumari Yash Prashar |
| author_facet | Souravh Bais Renu Kumari Yash Prashar |
| author_sort | Souravh Bais |
| collection | DOAJ |
| description | Objective: To evaluate the effect of sinapic acid against Aluminium chloride-induced dementia of Alzheimer's disease (AD) type in rat.Methods: The study was designed to induce dementia by chronic exposure of aluminium chloride at a dose of 175 mg/kg, p.o. for a period of 25 days in rats and then divided into different groups, i.e. Treatment group, negative control and two groups of sinapic acid, (at a dose of 20 and 40mg/kg, p.o.), where these groups treated and observed till the 35th day of experimental trial. The behavioural, neuronal and biochemical parameters were determined during or end of experiment. Histological changes in the brain were also observed.Results: Aluminium chloride at a dose of 175 mg/kg, o.p. had significantly induced the dementia and sinapic acid, at a dose of 40 mg/kg, p.o., possessed therapeutic effect against Aluminium chloride induced-dementia of AD type in rats.Conclusions: Sinapic acid is a class of compound wide spread in plant kingdom and could be a better source of neutraceuticals in brain disorders. The compound showed an in vivo MAO-A and MAO-B inhibiting activity and their role in Alzheimer's disease type of dementia was unexplored. The article also provides information on acute toxicity of sinapic acid with no toxicological sign on brain with chronic dose of AlCl3. |
| first_indexed | 2024-12-17T10:41:50Z |
| format | Article |
| id | doaj.art-1cd6ffbb585649a5aefcc54355b3c7b7 |
| institution | Directory Open Access Journal |
| issn | 2221-6189 2589-5516 |
| language | English |
| last_indexed | 2024-12-17T10:41:50Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Acute Disease |
| spelling | doaj.art-1cd6ffbb585649a5aefcc54355b3c7b72022-12-21T21:52:14ZengWolters Kluwer Medknow PublicationsJournal of Acute Disease2221-61892589-55162017-01-0164154162Therapeutic effect of Sinapic acid in aluminium chloride induced dementia of Alzheimer's type in ratsSouravh BaisRenu KumariYash PrasharObjective: To evaluate the effect of sinapic acid against Aluminium chloride-induced dementia of Alzheimer's disease (AD) type in rat.Methods: The study was designed to induce dementia by chronic exposure of aluminium chloride at a dose of 175 mg/kg, p.o. for a period of 25 days in rats and then divided into different groups, i.e. Treatment group, negative control and two groups of sinapic acid, (at a dose of 20 and 40mg/kg, p.o.), where these groups treated and observed till the 35th day of experimental trial. The behavioural, neuronal and biochemical parameters were determined during or end of experiment. Histological changes in the brain were also observed.Results: Aluminium chloride at a dose of 175 mg/kg, o.p. had significantly induced the dementia and sinapic acid, at a dose of 40 mg/kg, p.o., possessed therapeutic effect against Aluminium chloride induced-dementia of AD type in rats.Conclusions: Sinapic acid is a class of compound wide spread in plant kingdom and could be a better source of neutraceuticals in brain disorders. The compound showed an in vivo MAO-A and MAO-B inhibiting activity and their role in Alzheimer's disease type of dementia was unexplored. The article also provides information on acute toxicity of sinapic acid with no toxicological sign on brain with chronic dose of AlCl3.http://www.jadweb.org/article.asp?issn=2221-6189;year=2017;volume=6;issue=4;spage=154;epage=162;aulast=BaisDementiaAlzheimer's diseaseAluminium chlorideSinapic acidPharmacologicalBiochemicalHistopathology |
| spellingShingle | Souravh Bais Renu Kumari Yash Prashar Therapeutic effect of Sinapic acid in aluminium chloride induced dementia of Alzheimer's type in rats Journal of Acute Disease Dementia Alzheimer's disease Aluminium chloride Sinapic acid Pharmacological Biochemical Histopathology |
| title | Therapeutic effect of Sinapic acid in aluminium chloride induced dementia of Alzheimer's type in rats |
| title_full | Therapeutic effect of Sinapic acid in aluminium chloride induced dementia of Alzheimer's type in rats |
| title_fullStr | Therapeutic effect of Sinapic acid in aluminium chloride induced dementia of Alzheimer's type in rats |
| title_full_unstemmed | Therapeutic effect of Sinapic acid in aluminium chloride induced dementia of Alzheimer's type in rats |
| title_short | Therapeutic effect of Sinapic acid in aluminium chloride induced dementia of Alzheimer's type in rats |
| title_sort | therapeutic effect of sinapic acid in aluminium chloride induced dementia of alzheimer s type in rats |
| topic | Dementia Alzheimer's disease Aluminium chloride Sinapic acid Pharmacological Biochemical Histopathology |
| url | http://www.jadweb.org/article.asp?issn=2221-6189;year=2017;volume=6;issue=4;spage=154;epage=162;aulast=Bais |
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