Neoadjuvant Radiochemotherapy Alters the Immune and Metabolic Microenvironment in Oral Cancer—Analyses of CD68, CD163, TGF-β1, GLUT-1 and HIF-1α Expressions

Neoadjuvant Radiochemotherapy Alters the Immune and Metabolic Microenvironment in Oral Cancer—Analyses of CD68, CD163, TGF-β1, GLUT-1 and HIF-1α Expressions

Background: The first-line treatment of oral squamous cell carcinoma (OSCC) involves surgical tumor resection, followed by adjuvant radio(chemo)therapy (R(C)T) in advanced cases. Neoadjuvant radio- and/or chemotherapy has failed to show improved survival in OSCC. Recently, neoadjuvant immunotherapy...

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Bibliographic Details
Main Authors: Manuel Weber, Jutta Ries, Kristina Braun, Falk Wehrhan, Luitpold Distel, Carol Geppert, Rainer Lutz, Marco Kesting, Leah Trumet
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cells
Subjects:
macrophage polarization
immune tolerance
hypoxia
metabolism
induction therapy
RCT
Online Access:https://www.mdpi.com/2073-4409/13/5/397

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