Effects of “Longitudinal Gastrojejunostomy” on Malabsorption in a Rat Model of Short Bowel Syndrome
Objective:Short bowel syndrome (SBS) is a serious and chronic disorder of inadequate absorption of nutrients and fluid from the intestines. The most significant symptom of SBS is malnutrition. Weight loss due to malnutrition raised the morbidity and mortality rates of patients to a disappointing lev...
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| Format: | Article |
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Galenos Yayinevi
2023-03-01
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| Series: | Bagcilar Medical Bulletin |
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http://behmedicalbulletin.org/archives/archive-detail/article-preview/effects-of-longitudinal-gastrojejunostomy-on-malab/58575
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| author | Sinan Arıcı Osman Bilgin Gülçiçek Aytaç Biricik Erkan Yavuz Hakan Yiğitbaş Candaş Erçetin Aslı Kahraman Akkalp Atilla Çelik |
| author_facet | Sinan Arıcı Osman Bilgin Gülçiçek Aytaç Biricik Erkan Yavuz Hakan Yiğitbaş Candaş Erçetin Aslı Kahraman Akkalp Atilla Çelik |
| author_sort | Sinan Arıcı |
| collection | DOAJ |
| description | Objective:Short bowel syndrome (SBS) is a serious and chronic disorder of inadequate absorption of nutrients and fluid from the intestines. The most significant symptom of SBS is malnutrition. Weight loss due to malnutrition raised the morbidity and mortality rates of patients to a disappointing level. The use of making longitudinal gastrojejunostomy is a technique to grow neomucosa or intestinal metaplasia in the gastric mucosal surface and increase the intestinal transit time.Method:Three groups (Sham, SBS, longitudinal gastrojejunostomy) were created for 24 Wistar-Hannover rats. The 1st group was determined as the Sham group. SBS was induced in animals in group 2 with appropriate intestinal resection. Longitudinal gastrojejunostomy was additionally performed in rats with SBS in group 3. At the end of the 14th day all rats were weighted, euthanized, and blood sample was collected and anastomotic parts were resected for histopathological examination.Results:Weight loss was significantly less in group 3 and vitamin B12 and GLP-2 levels were significantly higher in group 3 compared to group 2. Longitudinal antiperistaltic gastrojejunostomy promotes intestinal metaplasia in the gastric mucosa and increased the absorption surface.Conclusion:This surgical procedure can be used to increase the absorption surface area in SBS. However, this needs to be supported by sufficiently robust clinical trials. |
| first_indexed | 2024-04-10T04:05:43Z |
| format | Article |
| id | doaj.art-1cd80fb9353f4f9891daa0a7a3ab5643 |
| institution | Directory Open Access Journal |
| issn | 2547-9431 |
| language | English |
| last_indexed | 2024-04-10T04:05:43Z |
| publishDate | 2023-03-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Bagcilar Medical Bulletin |
| spelling | doaj.art-1cd80fb9353f4f9891daa0a7a3ab56432023-03-13T06:16:09ZengGalenos YayineviBagcilar Medical Bulletin2547-94312023-03-0181273210.4274/BMB.galenos.2023.2022-09-07313049054Effects of “Longitudinal Gastrojejunostomy” on Malabsorption in a Rat Model of Short Bowel SyndromeSinan Arıcı0Osman Bilgin Gülçiçek1Aytaç Biricik2Erkan Yavuz3Hakan Yiğitbaş4Candaş Erçetin5Aslı Kahraman Akkalp6Atilla Çelik7 University of Health Sciences Turkey, Bursa Yüksek İhtisas Training and Research Hospital, Clinic of General Surgery, Bursa, Turkey University of Health Sciences Turkey, İstanbul Bağcılar Training and Research Hospital, Clinic of General Surgery, İstanbul, Turkey Sakarya University Faculty of Medicine, Department of Oncological Surgery, Sakarya, Turkey University of Health Sciences Turkey, İstanbul Bağcılar Training and Research Hospital, Clinic of General Surgery, İstanbul, Turkey University of Health Sciences Turkey, İstanbul Bağcılar Training and Research Hospital, Clinic of General Surgery, İstanbul, Turkey University of Health Sciences Turkey, İstanbul Bağcılar Training and Research Hospital, Clinic of General Surgery, İstanbul, Turkey İzmir Katip Çelebi University Faculty of Medicine, Department of Pathology, İzmir, Turkey University of Health Sciences Turkey, İstanbul Bağcılar Training and Research Hospital, Clinic of General Surgery, İstanbul, Turkey Objective:Short bowel syndrome (SBS) is a serious and chronic disorder of inadequate absorption of nutrients and fluid from the intestines. The most significant symptom of SBS is malnutrition. Weight loss due to malnutrition raised the morbidity and mortality rates of patients to a disappointing level. The use of making longitudinal gastrojejunostomy is a technique to grow neomucosa or intestinal metaplasia in the gastric mucosal surface and increase the intestinal transit time.Method:Three groups (Sham, SBS, longitudinal gastrojejunostomy) were created for 24 Wistar-Hannover rats. The 1st group was determined as the Sham group. SBS was induced in animals in group 2 with appropriate intestinal resection. Longitudinal gastrojejunostomy was additionally performed in rats with SBS in group 3. At the end of the 14th day all rats were weighted, euthanized, and blood sample was collected and anastomotic parts were resected for histopathological examination.Results:Weight loss was significantly less in group 3 and vitamin B12 and GLP-2 levels were significantly higher in group 3 compared to group 2. Longitudinal antiperistaltic gastrojejunostomy promotes intestinal metaplasia in the gastric mucosa and increased the absorption surface.Conclusion:This surgical procedure can be used to increase the absorption surface area in SBS. However, this needs to be supported by sufficiently robust clinical trials. http://behmedicalbulletin.org/archives/archive-detail/article-preview/effects-of-longitudinal-gastrojejunostomy-on-malab/58575 intestinal metaplasialongitudinal gastrojejunostomyshort bowel syndrome |
| spellingShingle | Sinan Arıcı Osman Bilgin Gülçiçek Aytaç Biricik Erkan Yavuz Hakan Yiğitbaş Candaş Erçetin Aslı Kahraman Akkalp Atilla Çelik Effects of “Longitudinal Gastrojejunostomy” on Malabsorption in a Rat Model of Short Bowel Syndrome Bagcilar Medical Bulletin intestinal metaplasia longitudinal gastrojejunostomy short bowel syndrome |
| title | Effects of “Longitudinal Gastrojejunostomy” on Malabsorption in a Rat Model of Short Bowel Syndrome |
| title_full | Effects of “Longitudinal Gastrojejunostomy” on Malabsorption in a Rat Model of Short Bowel Syndrome |
| title_fullStr | Effects of “Longitudinal Gastrojejunostomy” on Malabsorption in a Rat Model of Short Bowel Syndrome |
| title_full_unstemmed | Effects of “Longitudinal Gastrojejunostomy” on Malabsorption in a Rat Model of Short Bowel Syndrome |
| title_short | Effects of “Longitudinal Gastrojejunostomy” on Malabsorption in a Rat Model of Short Bowel Syndrome |
| title_sort | effects of longitudinal gastrojejunostomy on malabsorption in a rat model of short bowel syndrome |
| topic | intestinal metaplasia longitudinal gastrojejunostomy short bowel syndrome |
| url |
http://behmedicalbulletin.org/archives/archive-detail/article-preview/effects-of-longitudinal-gastrojejunostomy-on-malab/58575
|
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