Comparative Study of Chemical Stability of a PK20 Opioid–Neurotensin Hybrid Peptide and Its Analogue [Ile<sup>9</sup>]PK20—The Effect of Isomerism of a Single Amino Acid

Comparative Study of Chemical Stability of a PK20 Opioid–Neurotensin Hybrid Peptide and Its Analogue [Ile<sup>9</sup>]PK20—The Effect of Isomerism of a Single Amino Acid

Chemical stability is one of the main problems during the discovery and development of potent drugs. When ignored, it may lead to unreliable biological and pharmacokinetics data, especially regarding the degradation of products’ possible toxicity. Recently, two biologically active drug candidates we...

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Bibliographic Details
Main Authors: Barbara Żyżyńska-Granica, Adriano Mollica, Azzurra Stefanucci, Sebastian Granica, Patrycja Kleczkowska
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
hybrid peptides
stability
degradation
chemical structure
Online Access:https://www.mdpi.com/1422-0067/23/18/10839

Internet

https://www.mdpi.com/1422-0067/23/18/10839

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