Chitosan and Cyclodextrins—Versatile Materials Used to Create Drug Delivery Systems for Gastrointestinal Cancers
Gastrointestinal cancers are characterized by a frequent incidence, a high number of associated deaths, and a tremendous burden on the medical system and patients worldwide. As conventional chemotherapeutic drugs face numerous limitations, researchers started to investigate better alternatives for e...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/16/1/43 |
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| author | Alfred Najm Adelina-Gabriela Niculescu Alexandra Bolocan Marius Rădulescu Alexandru Mihai Grumezescu Mircea Beuran Bogdan Severus Gaspar |
| author_facet | Alfred Najm Adelina-Gabriela Niculescu Alexandra Bolocan Marius Rădulescu Alexandru Mihai Grumezescu Mircea Beuran Bogdan Severus Gaspar |
| author_sort | Alfred Najm |
| collection | DOAJ |
| description | Gastrointestinal cancers are characterized by a frequent incidence, a high number of associated deaths, and a tremendous burden on the medical system and patients worldwide. As conventional chemotherapeutic drugs face numerous limitations, researchers started to investigate better alternatives for extending drug efficacy and limiting adverse effects. A remarkably increasing interest has been addressed to chitosan and cyclodextrins, two highly versatile natural carbohydrate materials endowed with unique physicochemical properties. In this respect, numerous studies reported on fabricating various chitosan and cyclodextrin-based formulations that enabled prolonged circulation times, improved cellular internalization of carried drugs, preferential uptake by the targeted cells, reduced side effects, enhanced apoptosis rates, and increased tumor suppression rates. Therefore, this paper aims to briefly present the advantageous properties of these oligo- and polysaccharides for designing drug delivery systems, further focusing the discussion on nanocarrier systems based on chitosan/cyclodextrins for treating different gastrointestinal cancers. Specifically, there are reviewed studies describing promising solutions for colorectal, liver, gastric, pancreatic, and other types of cancers of the digestive system towards creating an updated framework of what concerns anticancer chitosan/cyclodextrin-based drug delivery systems. |
| first_indexed | 2024-03-08T10:38:07Z |
| format | Article |
| id | doaj.art-1cd888c09af643feb9dbf4f816182aa6 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-08T10:38:07Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-1cd888c09af643feb9dbf4f816182aa62024-01-26T18:06:22ZengMDPI AGPharmaceutics1999-49232023-12-011614310.3390/pharmaceutics16010043Chitosan and Cyclodextrins—Versatile Materials Used to Create Drug Delivery Systems for Gastrointestinal CancersAlfred Najm0Adelina-Gabriela Niculescu1Alexandra Bolocan2Marius Rădulescu3Alexandru Mihai Grumezescu4Mircea Beuran5Bogdan Severus Gaspar6Department of Surgery, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari, Sector 5, 050474 Bucharest, RomaniaResearch Institute of the University of Bucharest—ICUB, University of Bucharest, 050657 Bucharest, RomaniaGeneral Surgery Department, Carol Davila University of Medicine and Pharmacy, The University Emergency Hospital of Bucharest, 050098 Bucharest, RomaniaDepartment of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Politehnica University of Bucharest, 011061 Bucharest, RomaniaResearch Institute of the University of Bucharest—ICUB, University of Bucharest, 050657 Bucharest, RomaniaDepartment of Surgery, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari, Sector 5, 050474 Bucharest, RomaniaDepartment of Surgery, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari, Sector 5, 050474 Bucharest, RomaniaGastrointestinal cancers are characterized by a frequent incidence, a high number of associated deaths, and a tremendous burden on the medical system and patients worldwide. As conventional chemotherapeutic drugs face numerous limitations, researchers started to investigate better alternatives for extending drug efficacy and limiting adverse effects. A remarkably increasing interest has been addressed to chitosan and cyclodextrins, two highly versatile natural carbohydrate materials endowed with unique physicochemical properties. In this respect, numerous studies reported on fabricating various chitosan and cyclodextrin-based formulations that enabled prolonged circulation times, improved cellular internalization of carried drugs, preferential uptake by the targeted cells, reduced side effects, enhanced apoptosis rates, and increased tumor suppression rates. Therefore, this paper aims to briefly present the advantageous properties of these oligo- and polysaccharides for designing drug delivery systems, further focusing the discussion on nanocarrier systems based on chitosan/cyclodextrins for treating different gastrointestinal cancers. Specifically, there are reviewed studies describing promising solutions for colorectal, liver, gastric, pancreatic, and other types of cancers of the digestive system towards creating an updated framework of what concerns anticancer chitosan/cyclodextrin-based drug delivery systems.https://www.mdpi.com/1999-4923/16/1/43gastrointestinal cancersdrug delivery systemschitosan-based nanocarrierscyclodextrin-based delivery systemsinclusion complexesnovel antitumor approaches |
| spellingShingle | Alfred Najm Adelina-Gabriela Niculescu Alexandra Bolocan Marius Rădulescu Alexandru Mihai Grumezescu Mircea Beuran Bogdan Severus Gaspar Chitosan and Cyclodextrins—Versatile Materials Used to Create Drug Delivery Systems for Gastrointestinal Cancers Pharmaceutics gastrointestinal cancers drug delivery systems chitosan-based nanocarriers cyclodextrin-based delivery systems inclusion complexes novel antitumor approaches |
| title | Chitosan and Cyclodextrins—Versatile Materials Used to Create Drug Delivery Systems for Gastrointestinal Cancers |
| title_full | Chitosan and Cyclodextrins—Versatile Materials Used to Create Drug Delivery Systems for Gastrointestinal Cancers |
| title_fullStr | Chitosan and Cyclodextrins—Versatile Materials Used to Create Drug Delivery Systems for Gastrointestinal Cancers |
| title_full_unstemmed | Chitosan and Cyclodextrins—Versatile Materials Used to Create Drug Delivery Systems for Gastrointestinal Cancers |
| title_short | Chitosan and Cyclodextrins—Versatile Materials Used to Create Drug Delivery Systems for Gastrointestinal Cancers |
| title_sort | chitosan and cyclodextrins versatile materials used to create drug delivery systems for gastrointestinal cancers |
| topic | gastrointestinal cancers drug delivery systems chitosan-based nanocarriers cyclodextrin-based delivery systems inclusion complexes novel antitumor approaches |
| url | https://www.mdpi.com/1999-4923/16/1/43 |
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