Integrative analysis of WDR12 as a potential prognostic and immunological biomarker in multiple human tumors
Background: Mammalian WD-repeat protein 12 (WDR12), a family member of proteins containing repeats of tryptophan-aspartic acid (WD), is a potential homolog of yeast Ytm1p and consists of seven repeats of WD.Aim of the study: This study aims to investigate the potential oncogenic effects of WDR12 in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.1008502/full |
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| author | Refaat A. Eid Muhammad Alaa Eldeen Mohamed A. Soltan Mubarak Al-Shraim Majed Aldehri Leena S. Alqahtani Ghadi Alsharif Sarah Albogami Ibrahim Jafri Eman Fayad Moon Nyeo Park Shabana Bibi Shabana Bibi Mohammed Y. Behairy Bonglee Kim Mohamed Samir A. Zaki Mohamed Samir A. Zaki |
| author_facet | Refaat A. Eid Muhammad Alaa Eldeen Mohamed A. Soltan Mubarak Al-Shraim Majed Aldehri Leena S. Alqahtani Ghadi Alsharif Sarah Albogami Ibrahim Jafri Eman Fayad Moon Nyeo Park Shabana Bibi Shabana Bibi Mohammed Y. Behairy Bonglee Kim Mohamed Samir A. Zaki Mohamed Samir A. Zaki |
| author_sort | Refaat A. Eid |
| collection | DOAJ |
| description | Background: Mammalian WD-repeat protein 12 (WDR12), a family member of proteins containing repeats of tryptophan-aspartic acid (WD), is a potential homolog of yeast Ytm1p and consists of seven repeats of WD.Aim of the study: This study aims to investigate the potential oncogenic effects of WDR12 in various human malignancies throughout a pan-cancer analysis that has been carried out to examine the various patterns in which this gene is expressed and behaves in tumor tissues.Methods: Herein, we used The Cancer Genome Atlas (TCGA) and various computational tools to explore expression profiles, prognostic relevance, genetic mutations, immune cell infiltration, as well as the functional characteristics of WDR12 in multiple human cancers.Results: We found that WDR12 was inconsistently expressed in various cancers and that variations in WDR12 expression predicted survival consequences for cancer patients. Furthermore, we observed a significant correlation between WDR12 gene mutation levels and the prognosis of some tumors. Furthermore, significant correlations were found between WDR12 expression patterns and cancer-associated fibroblast (CAF) infiltration, myeloid-derived suppressor cells (MDSCs), tumor mutation burden, microsatellite instability and immunoregulators. Ultimately, pathway enrichment analysis revealed that WDR12-related pathways are involved in carcinogenesis.Conclusions: The findings of our study are stisfactory, demonstrating that WDR12 could serve as a promising reliable prognostic biomarker, as well as a therapeutic target for novel cancer therapeutic approaches. |
| first_indexed | 2024-04-10T22:36:59Z |
| format | Article |
| id | doaj.art-1cd89c18f86348dc97d322c460dd403d |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-10T22:36:59Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-1cd89c18f86348dc97d322c460dd403d2023-01-16T11:11:04ZengFrontiers Media S.A.Frontiers in Genetics1664-80212023-01-011310.3389/fgene.2022.10085021008502Integrative analysis of WDR12 as a potential prognostic and immunological biomarker in multiple human tumorsRefaat A. Eid0Muhammad Alaa Eldeen1Mohamed A. Soltan2Mubarak Al-Shraim3Majed Aldehri4Leena S. Alqahtani5Ghadi Alsharif6Sarah Albogami7Ibrahim Jafri8Eman Fayad9Moon Nyeo Park10Shabana Bibi11Shabana Bibi12Mohammed Y. Behairy13Bonglee Kim14Mohamed Samir A. Zaki15Mohamed Samir A. Zaki16Pathology Department, College of Medicine, King Khalid University, Abha, Saudi ArabiaCell Biology, Histology & Genetics Division, Biology Department, Faculty of Science, Zagazig University, Zagazig, EgyptDepartment of Microbiology and Immunology, Faculty of Pharmacy, Sinai University, Ismailia, EgyptPathology Department, College of Medicine, King Khalid University, Abha, Saudi ArabiaAnatomy Department, College of Medicine, King Khalid University, Abha, Saudi ArabiaDepartment of Biochemistry, College of Science, University of Jeddah, Jeddah, Saudi ArabiaCollege of Clinical Laboratory Sciences, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi ArabiaDepartment of Biotechnology, College of Sciences, Taif University, Taif, Saudi ArabiaDepartment of Biotechnology, College of Sciences, Taif University, Taif, Saudi ArabiaDepartment of Biotechnology, College of Sciences, Taif University, Taif, Saudi ArabiaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, South KoreaDepartment of Biosciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan0Yunnan Herbal Laboratory, College of Ecology and Environmental Sciences, Yunnan University, Kunming, Yunnan, China1Department of Microbiology and Immunology, Faculty of Pharmacy, University of Sadat City, Sadat City, EgyptDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, South KoreaAnatomy Department, College of Medicine, King Khalid University, Abha, Saudi Arabia2Department of Histology and Cell Biology, College of Medicine, Zagazig University, Zagazig, EgyptBackground: Mammalian WD-repeat protein 12 (WDR12), a family member of proteins containing repeats of tryptophan-aspartic acid (WD), is a potential homolog of yeast Ytm1p and consists of seven repeats of WD.Aim of the study: This study aims to investigate the potential oncogenic effects of WDR12 in various human malignancies throughout a pan-cancer analysis that has been carried out to examine the various patterns in which this gene is expressed and behaves in tumor tissues.Methods: Herein, we used The Cancer Genome Atlas (TCGA) and various computational tools to explore expression profiles, prognostic relevance, genetic mutations, immune cell infiltration, as well as the functional characteristics of WDR12 in multiple human cancers.Results: We found that WDR12 was inconsistently expressed in various cancers and that variations in WDR12 expression predicted survival consequences for cancer patients. Furthermore, we observed a significant correlation between WDR12 gene mutation levels and the prognosis of some tumors. Furthermore, significant correlations were found between WDR12 expression patterns and cancer-associated fibroblast (CAF) infiltration, myeloid-derived suppressor cells (MDSCs), tumor mutation burden, microsatellite instability and immunoregulators. Ultimately, pathway enrichment analysis revealed that WDR12-related pathways are involved in carcinogenesis.Conclusions: The findings of our study are stisfactory, demonstrating that WDR12 could serve as a promising reliable prognostic biomarker, as well as a therapeutic target for novel cancer therapeutic approaches.https://www.frontiersin.org/articles/10.3389/fgene.2022.1008502/fullWDR12pan-cancerprognosisimmunotherapyexpression |
| spellingShingle | Refaat A. Eid Muhammad Alaa Eldeen Mohamed A. Soltan Mubarak Al-Shraim Majed Aldehri Leena S. Alqahtani Ghadi Alsharif Sarah Albogami Ibrahim Jafri Eman Fayad Moon Nyeo Park Shabana Bibi Shabana Bibi Mohammed Y. Behairy Bonglee Kim Mohamed Samir A. Zaki Mohamed Samir A. Zaki Integrative analysis of WDR12 as a potential prognostic and immunological biomarker in multiple human tumors Frontiers in Genetics WDR12 pan-cancer prognosis immunotherapy expression |
| title | Integrative analysis of WDR12 as a potential prognostic and immunological biomarker in multiple human tumors |
| title_full | Integrative analysis of WDR12 as a potential prognostic and immunological biomarker in multiple human tumors |
| title_fullStr | Integrative analysis of WDR12 as a potential prognostic and immunological biomarker in multiple human tumors |
| title_full_unstemmed | Integrative analysis of WDR12 as a potential prognostic and immunological biomarker in multiple human tumors |
| title_short | Integrative analysis of WDR12 as a potential prognostic and immunological biomarker in multiple human tumors |
| title_sort | integrative analysis of wdr12 as a potential prognostic and immunological biomarker in multiple human tumors |
| topic | WDR12 pan-cancer prognosis immunotherapy expression |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.1008502/full |
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