Switching to Brimonidine/Ripasudil Fixed Combination from Brimonidine + Ripasudil
Kenji Inoue,1 Minako Shiokawa,1 Shiho Kunimatsu-Sanuki,2 Goji Tomita,1,3 Kyoko Ishida3 1Inouye Eye Hospital, Tokyo, Japan; 2Nishikasai Inouye Eye Hospital, Tokyo, Japan; 3Department of Ophthalmology, Toho University Ohashi Medical Center, Tokyo, JapanCorrespondence: Kenji Inoue, Inouye Eye Hospital,...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2024-02-01
|
| Series: | Clinical Ophthalmology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/switching-to-brimonidineripasudil-fixed-combination-from-brimonidine---peer-reviewed-fulltext-article-OPTH |
| _version_ | 1797319667825508352 |
|---|---|
| author | Inoue K Shiokawa M Kunimatsu-Sanuki S Tomita G Ishida K |
| author_facet | Inoue K Shiokawa M Kunimatsu-Sanuki S Tomita G Ishida K |
| author_sort | Inoue K |
| collection | DOAJ |
| description | Kenji Inoue,1 Minako Shiokawa,1 Shiho Kunimatsu-Sanuki,2 Goji Tomita,1,3 Kyoko Ishida3 1Inouye Eye Hospital, Tokyo, Japan; 2Nishikasai Inouye Eye Hospital, Tokyo, Japan; 3Department of Ophthalmology, Toho University Ohashi Medical Center, Tokyo, JapanCorrespondence: Kenji Inoue, Inouye Eye Hospital, 4-3 Kanda-surugadai, Chiyoda-ku, Tokyo, 101-0062, Japan, Tel +813-3295-0911 ; Fax +813-3295-0917, Email 2inoue-k@inouye-eye.or.jpPurpose: A fixed-combination eye drop has several advantages over combination therapy, however, the intraocular pressure (IOP)-lowering efficacy and safety of the newly available brimonidine + ripasudil fixed-combination (BRFC) eye drops after switching from brimonidine + ripasudil is yet to be established. Therefore, this study aimed to retrospectively investigate the 6-month safety, usability, and IOP-lowering efficacy of BRFC switched from brimonidine and ripasudil.Patients and Methods: Overall, 69 patients with primary open-angle glaucoma (69 eyes) receiving brimonidine + ripasudil were enrolled in this study. Brimonidine + ripasudil was discontinued, and treatment was switched to BRFC without a washout period. The IOP was compared before and at 3 and 6 months after switching to BRFC. The side effects, discontinued cases, and usability (a questionnaire survey) were also investigated.Results: The IOP was not significantly different after switching to BRFC (15.1 ± 3.3 mmHg at baseline, 15.9 ± 3.6 mmHg after 3 months, and 14.6 ± 3.3 mmHg after 6 months). Adverse reactions occurred in four patients (5.8%): allergic conjunctivitis, two patients; irritation, one patient; and blurred vision, one patient. Treatment was discontinued in five (7.2%) patients owing to allergic conjunctivitis, two patients; increased IOP, two patients; and blurred vision, one patient. In the questionnaire survey, 68 patients with eye pain, 67 with itching, 64 with conjunctival hyperemia, 64 with irritation, and 62 with blurred vision reported no change or improved conditions. Additionally, in response to the question regarding preferences for pre-treatment and fixed combinations, 14 participants (20.2%) favored pre-treatment, while 53 (76.8%) preferred fixed combinations.Conclusion: The IOP was maintained for 6 months, with satisfactory safety and comfort of use, with BRFC switched from brimonidine and ripasudil.Keywords: adverse reactions, brimonidine/ripasudil, intraocular pressure, fixed combination, switching, usability |
| first_indexed | 2024-03-08T04:11:16Z |
| format | Article |
| id | doaj.art-1cd9300e9c4a444b9066928d23855a8a |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-03-08T04:11:16Z |
| publishDate | 2024-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-1cd9300e9c4a444b9066928d23855a8a2024-02-08T18:28:25ZengDove Medical PressClinical Ophthalmology1177-54832024-02-01Volume 1842343090292Switching to Brimonidine/Ripasudil Fixed Combination from Brimonidine + RipasudilInoue KShiokawa MKunimatsu-Sanuki STomita GIshida KKenji Inoue,1 Minako Shiokawa,1 Shiho Kunimatsu-Sanuki,2 Goji Tomita,1,3 Kyoko Ishida3 1Inouye Eye Hospital, Tokyo, Japan; 2Nishikasai Inouye Eye Hospital, Tokyo, Japan; 3Department of Ophthalmology, Toho University Ohashi Medical Center, Tokyo, JapanCorrespondence: Kenji Inoue, Inouye Eye Hospital, 4-3 Kanda-surugadai, Chiyoda-ku, Tokyo, 101-0062, Japan, Tel +813-3295-0911 ; Fax +813-3295-0917, Email 2inoue-k@inouye-eye.or.jpPurpose: A fixed-combination eye drop has several advantages over combination therapy, however, the intraocular pressure (IOP)-lowering efficacy and safety of the newly available brimonidine + ripasudil fixed-combination (BRFC) eye drops after switching from brimonidine + ripasudil is yet to be established. Therefore, this study aimed to retrospectively investigate the 6-month safety, usability, and IOP-lowering efficacy of BRFC switched from brimonidine and ripasudil.Patients and Methods: Overall, 69 patients with primary open-angle glaucoma (69 eyes) receiving brimonidine + ripasudil were enrolled in this study. Brimonidine + ripasudil was discontinued, and treatment was switched to BRFC without a washout period. The IOP was compared before and at 3 and 6 months after switching to BRFC. The side effects, discontinued cases, and usability (a questionnaire survey) were also investigated.Results: The IOP was not significantly different after switching to BRFC (15.1 ± 3.3 mmHg at baseline, 15.9 ± 3.6 mmHg after 3 months, and 14.6 ± 3.3 mmHg after 6 months). Adverse reactions occurred in four patients (5.8%): allergic conjunctivitis, two patients; irritation, one patient; and blurred vision, one patient. Treatment was discontinued in five (7.2%) patients owing to allergic conjunctivitis, two patients; increased IOP, two patients; and blurred vision, one patient. In the questionnaire survey, 68 patients with eye pain, 67 with itching, 64 with conjunctival hyperemia, 64 with irritation, and 62 with blurred vision reported no change or improved conditions. Additionally, in response to the question regarding preferences for pre-treatment and fixed combinations, 14 participants (20.2%) favored pre-treatment, while 53 (76.8%) preferred fixed combinations.Conclusion: The IOP was maintained for 6 months, with satisfactory safety and comfort of use, with BRFC switched from brimonidine and ripasudil.Keywords: adverse reactions, brimonidine/ripasudil, intraocular pressure, fixed combination, switching, usabilityhttps://www.dovepress.com/switching-to-brimonidineripasudil-fixed-combination-from-brimonidine---peer-reviewed-fulltext-article-OPTHadverse reactionsbrimonidine/ripasudilintraocular pressurefixed combinationswitchingusability |
| spellingShingle | Inoue K Shiokawa M Kunimatsu-Sanuki S Tomita G Ishida K Switching to Brimonidine/Ripasudil Fixed Combination from Brimonidine + Ripasudil Clinical Ophthalmology adverse reactions brimonidine/ripasudil intraocular pressure fixed combination switching usability |
| title | Switching to Brimonidine/Ripasudil Fixed Combination from Brimonidine + Ripasudil |
| title_full | Switching to Brimonidine/Ripasudil Fixed Combination from Brimonidine + Ripasudil |
| title_fullStr | Switching to Brimonidine/Ripasudil Fixed Combination from Brimonidine + Ripasudil |
| title_full_unstemmed | Switching to Brimonidine/Ripasudil Fixed Combination from Brimonidine + Ripasudil |
| title_short | Switching to Brimonidine/Ripasudil Fixed Combination from Brimonidine + Ripasudil |
| title_sort | switching to brimonidine ripasudil fixed combination from brimonidine ripasudil |
| topic | adverse reactions brimonidine/ripasudil intraocular pressure fixed combination switching usability |
| url | https://www.dovepress.com/switching-to-brimonidineripasudil-fixed-combination-from-brimonidine---peer-reviewed-fulltext-article-OPTH |
| work_keys_str_mv | AT inouek switchingtobrimonidineripasudilfixedcombinationfrombrimonidineripasudil AT shiokawam switchingtobrimonidineripasudilfixedcombinationfrombrimonidineripasudil AT kunimatsusanukis switchingtobrimonidineripasudilfixedcombinationfrombrimonidineripasudil AT tomitag switchingtobrimonidineripasudilfixedcombinationfrombrimonidineripasudil AT ishidak switchingtobrimonidineripasudilfixedcombinationfrombrimonidineripasudil |