Sex Differences in Antiretroviral Therapy Initiation in Pediatric HIV Infection.
The incidence and severity of infections in childhood is typically greater in males. The basis for these observed sex differences is not well understood, and potentially may facilitate novel approaches to reducing disease from a range of conditions. We here investigated sex differences in HIV-infect...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4494714?pdf=render |
| _version_ | 1818275407701475328 |
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| author | Masahiko Mori Emily Adland Paolo Paioni Alice Swordy Luisa Mori Leana Laker Maximilian Muenchhoff Philippa C Matthews Gareth Tudor-Williams Nora Lavandier Anriette van Zyl Jacob Hurst Bruce D Walker Thumbi Ndung'u Andrew Prendergast Philip Goulder Pieter Jooste |
| author_facet | Masahiko Mori Emily Adland Paolo Paioni Alice Swordy Luisa Mori Leana Laker Maximilian Muenchhoff Philippa C Matthews Gareth Tudor-Williams Nora Lavandier Anriette van Zyl Jacob Hurst Bruce D Walker Thumbi Ndung'u Andrew Prendergast Philip Goulder Pieter Jooste |
| author_sort | Masahiko Mori |
| collection | DOAJ |
| description | The incidence and severity of infections in childhood is typically greater in males. The basis for these observed sex differences is not well understood, and potentially may facilitate novel approaches to reducing disease from a range of conditions. We here investigated sex differences in HIV-infected children in relation to antiretroviral therapy (ART) initiation and post-treatment outcome. In a South African cohort of 2,101 HIV-infected children, we observed that absolute CD4+ count and CD4% were significantly higher in ART-naïve female, compared to age-matched male, HIV-infected children. Absolute CD4 count and CD4% were also significantly higher in HIV-uninfected female versus male neonates. We next showed that significantly more male than female children were initiated on ART (47% female); and children not meeting criteria to start ART by >5 yrs were more frequently female (59%; p<0.001). Among ART-treated children, immune reconstitution of CD4 T-cells was more rapid and more complete in female children, even after adjustment for pre-ART absolute CD4 count or CD4% (p=0.011, p=0.030, respectively). However, while ART was initiated as a result of meeting CD4 criteria less often in females (45%), ART initiation as a result of clinical disease in children whose CD4 counts were above treatment thresholds occurred more often in females (57%, p<0.001). The main sex difference in morbidity observed in children initiating ART above CD4 thresholds, above that of TB disease, was as a result of wasting and stunting observed in females with above-threshold CD4 counts (p=0.002). These findings suggest the possibility that optimal treatment of HIV-infected children might incorporate differential CD4 treatment thresholds for ART initiation according to sex. |
| first_indexed | 2024-12-12T22:29:16Z |
| format | Article |
| id | doaj.art-1cd9df84100843a1a57354ccb2e6fb6e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T22:29:16Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1cd9df84100843a1a57354ccb2e6fb6e2022-12-22T00:09:39ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01107e013159110.1371/journal.pone.0131591Sex Differences in Antiretroviral Therapy Initiation in Pediatric HIV Infection.Masahiko MoriEmily AdlandPaolo PaioniAlice SwordyLuisa MoriLeana LakerMaximilian MuenchhoffPhilippa C MatthewsGareth Tudor-WilliamsNora LavandierAnriette van ZylJacob HurstBruce D WalkerThumbi Ndung'uAndrew PrendergastPhilip GoulderPieter JoosteThe incidence and severity of infections in childhood is typically greater in males. The basis for these observed sex differences is not well understood, and potentially may facilitate novel approaches to reducing disease from a range of conditions. We here investigated sex differences in HIV-infected children in relation to antiretroviral therapy (ART) initiation and post-treatment outcome. In a South African cohort of 2,101 HIV-infected children, we observed that absolute CD4+ count and CD4% were significantly higher in ART-naïve female, compared to age-matched male, HIV-infected children. Absolute CD4 count and CD4% were also significantly higher in HIV-uninfected female versus male neonates. We next showed that significantly more male than female children were initiated on ART (47% female); and children not meeting criteria to start ART by >5 yrs were more frequently female (59%; p<0.001). Among ART-treated children, immune reconstitution of CD4 T-cells was more rapid and more complete in female children, even after adjustment for pre-ART absolute CD4 count or CD4% (p=0.011, p=0.030, respectively). However, while ART was initiated as a result of meeting CD4 criteria less often in females (45%), ART initiation as a result of clinical disease in children whose CD4 counts were above treatment thresholds occurred more often in females (57%, p<0.001). The main sex difference in morbidity observed in children initiating ART above CD4 thresholds, above that of TB disease, was as a result of wasting and stunting observed in females with above-threshold CD4 counts (p=0.002). These findings suggest the possibility that optimal treatment of HIV-infected children might incorporate differential CD4 treatment thresholds for ART initiation according to sex.http://europepmc.org/articles/PMC4494714?pdf=render |
| spellingShingle | Masahiko Mori Emily Adland Paolo Paioni Alice Swordy Luisa Mori Leana Laker Maximilian Muenchhoff Philippa C Matthews Gareth Tudor-Williams Nora Lavandier Anriette van Zyl Jacob Hurst Bruce D Walker Thumbi Ndung'u Andrew Prendergast Philip Goulder Pieter Jooste Sex Differences in Antiretroviral Therapy Initiation in Pediatric HIV Infection. PLoS ONE |
| title | Sex Differences in Antiretroviral Therapy Initiation in Pediatric HIV Infection. |
| title_full | Sex Differences in Antiretroviral Therapy Initiation in Pediatric HIV Infection. |
| title_fullStr | Sex Differences in Antiretroviral Therapy Initiation in Pediatric HIV Infection. |
| title_full_unstemmed | Sex Differences in Antiretroviral Therapy Initiation in Pediatric HIV Infection. |
| title_short | Sex Differences in Antiretroviral Therapy Initiation in Pediatric HIV Infection. |
| title_sort | sex differences in antiretroviral therapy initiation in pediatric hiv infection |
| url | http://europepmc.org/articles/PMC4494714?pdf=render |
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