Waist circumference and a body shape index and prostate cancer risk and mortality
Abstract We recently found a negative association between body mass index (BMI) and the risk of localised prostate cancer (PCa), no association with advanced PCa, and a positive association with PCa‐specific mortality. In a 15% subpopulation of that study, we here investigated the measures of abdomi...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-04-01
|
| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.3827 |
| _version_ | 1818662672849174528 |
|---|---|
| author | Sylvia H. J. Jochems Angela M. Wood Christel Häggström Marju Orho‐Melander Pär Stattin Tanja Stocks |
| author_facet | Sylvia H. J. Jochems Angela M. Wood Christel Häggström Marju Orho‐Melander Pär Stattin Tanja Stocks |
| author_sort | Sylvia H. J. Jochems |
| collection | DOAJ |
| description | Abstract We recently found a negative association between body mass index (BMI) and the risk of localised prostate cancer (PCa), no association with advanced PCa, and a positive association with PCa‐specific mortality. In a 15% subpopulation of that study, we here investigated the measures of abdominal adiposity including waist circumference (WC) and A Body Shape Index (ABSI) in relation to PCa risk and mortality. We used data from 58,457 men from four Swedish cohorts to assess WC and ABSI in relation to PCa risk according to cancer risk category, including localised asymptomatic and symptomatic PCa and advanced PCa, and PCa‐specific mortality. Cox regression models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). During, on average, 10 years of follow‐up, 3290 men were diagnosed with PCa and 387 died of PCa. WC was negatively associated with the risk of total PCa (HR per 10 cm, 0.95; 95% CI 0.92–0.99), localised PCa (HR per 10 cm, 0.93, 95% CI 0.88–0.96) and localised asymptomatic PCa cases detected through a prostate‐specific antigen (PSA) test (HR per 10 cm, 0.87, 95% CI 0.81–0.94). WC was not associated with the risk of advanced PCa (HR per 10 cm, 1.02, 95% CI 0.93–1.14) or with PCa‐specific mortality (HR per 10 cm, 1.04, 95% CI 0.92–1.19). ABSI showed no associations with the risk of PCa or PCa‐specific mortality. While the negative association between WC and the risk of localised PCa was partially driven by PSA‐detected PCa cases, no association was found between abdominal adiposity and clinically manifest PCa in our population. |
| first_indexed | 2024-12-17T05:04:41Z |
| format | Article |
| id | doaj.art-1cdbae403af94bff84eacf80233ef0f0 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-12-17T05:04:41Z |
| publishDate | 2021-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-1cdbae403af94bff84eacf80233ef0f02022-12-21T22:02:28ZengWileyCancer Medicine2045-76342021-04-011082885289610.1002/cam4.3827Waist circumference and a body shape index and prostate cancer risk and mortalitySylvia H. J. Jochems0Angela M. Wood1Christel Häggström2Marju Orho‐Melander3Pär Stattin4Tanja Stocks5Department of Clinical Sciences Lund Lund University Lund SwedenDepartment of Public Health and Primary Care University of Cambridge Cambridge UKDepartment of Public Health and Clinical Medicine Umeå University Umeå SwedenDepartment of Clinical Sciences Malmö Lund University Lund SwedenDepartment of Surgical Sciences Uppsala University Uppsala SwedenDepartment of Clinical Sciences Lund Lund University Lund SwedenAbstract We recently found a negative association between body mass index (BMI) and the risk of localised prostate cancer (PCa), no association with advanced PCa, and a positive association with PCa‐specific mortality. In a 15% subpopulation of that study, we here investigated the measures of abdominal adiposity including waist circumference (WC) and A Body Shape Index (ABSI) in relation to PCa risk and mortality. We used data from 58,457 men from four Swedish cohorts to assess WC and ABSI in relation to PCa risk according to cancer risk category, including localised asymptomatic and symptomatic PCa and advanced PCa, and PCa‐specific mortality. Cox regression models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). During, on average, 10 years of follow‐up, 3290 men were diagnosed with PCa and 387 died of PCa. WC was negatively associated with the risk of total PCa (HR per 10 cm, 0.95; 95% CI 0.92–0.99), localised PCa (HR per 10 cm, 0.93, 95% CI 0.88–0.96) and localised asymptomatic PCa cases detected through a prostate‐specific antigen (PSA) test (HR per 10 cm, 0.87, 95% CI 0.81–0.94). WC was not associated with the risk of advanced PCa (HR per 10 cm, 1.02, 95% CI 0.93–1.14) or with PCa‐specific mortality (HR per 10 cm, 1.04, 95% CI 0.92–1.19). ABSI showed no associations with the risk of PCa or PCa‐specific mortality. While the negative association between WC and the risk of localised PCa was partially driven by PSA‐detected PCa cases, no association was found between abdominal adiposity and clinically manifest PCa in our population.https://doi.org/10.1002/cam4.3827cancer risk factorsepidemiologyprognosisprostate cancer |
| spellingShingle | Sylvia H. J. Jochems Angela M. Wood Christel Häggström Marju Orho‐Melander Pär Stattin Tanja Stocks Waist circumference and a body shape index and prostate cancer risk and mortality Cancer Medicine cancer risk factors epidemiology prognosis prostate cancer |
| title | Waist circumference and a body shape index and prostate cancer risk and mortality |
| title_full | Waist circumference and a body shape index and prostate cancer risk and mortality |
| title_fullStr | Waist circumference and a body shape index and prostate cancer risk and mortality |
| title_full_unstemmed | Waist circumference and a body shape index and prostate cancer risk and mortality |
| title_short | Waist circumference and a body shape index and prostate cancer risk and mortality |
| title_sort | waist circumference and a body shape index and prostate cancer risk and mortality |
| topic | cancer risk factors epidemiology prognosis prostate cancer |
| url | https://doi.org/10.1002/cam4.3827 |
| work_keys_str_mv | AT sylviahjjochems waistcircumferenceandabodyshapeindexandprostatecancerriskandmortality AT angelamwood waistcircumferenceandabodyshapeindexandprostatecancerriskandmortality AT christelhaggstrom waistcircumferenceandabodyshapeindexandprostatecancerriskandmortality AT marjuorhomelander waistcircumferenceandabodyshapeindexandprostatecancerriskandmortality AT parstattin waistcircumferenceandabodyshapeindexandprostatecancerriskandmortality AT tanjastocks waistcircumferenceandabodyshapeindexandprostatecancerriskandmortality |