Frequency and Risk factors of Reoperation in LDLT Donors
Background: Liver transplantation (LT) is the definitive treatment for end-stage liver disease, acute liver failure, liver tumors, and metabolic diseases. Re-exploration after surgery is associated with poor clinical outcomes and is considered a quality-of-care measure. Objective: To determ...
| Autors principals: | , , , , , , |
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| Format: | Article |
| Idioma: | English |
| Publicat: |
Frontier Science Associates
2024-09-01
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| Col·lecció: | The International Journal of Frontier Sciences |
| Matèries: | |
| Accés en línia: | https://p2024.frontierscienceassociates.com.pk/index.php/tijfs/article/view/195 |
| _version_ | 1827059417168740352 |
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| author | Hamid Raza Laghari Aamir Bashir Muhammad Akram Ibrahim Asghar Usman Ali Rizvi Sirajuddin Umar Baloch |
| author_facet | Hamid Raza Laghari Aamir Bashir Muhammad Akram Ibrahim Asghar Usman Ali Rizvi Sirajuddin Umar Baloch |
| author_sort | Hamid Raza Laghari |
| collection | DOAJ |
| description |
Background:
Liver transplantation (LT) is the definitive treatment for end-stage liver disease, acute liver failure, liver tumors, and metabolic diseases. Re-exploration after surgery is associated with poor clinical outcomes and is considered a quality-of-care measure.
Objective:
To determine the frequency and risk factors of reoperation (early re-laparotomy) after hepatectomy in postoperative LDLT donors.
Materials and Methods:
A cross-sectional analytical study was conducted at the Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences between December 2023 and May 2024. This study included 672 LDLT donors aged > 18 years old. Data on donor age, sex, blood group, operation time, and re-exploration were collected. The primary endpoints were the frequency and causes of re-exploration, and the secondary endpoints included the association of re-exploration with clinical outcomes. Statistical analyses were performed using SPSS 25.0, with the significance level set at P < 0.05.
Blood group analysis revealed that 57.9% of reexplored donors had blood group B+.
Results:
The frequency of re-exploration was 2.8%. Among those requiring re-exploration, 42.1% were aged 21-28 years. The difference in re-exploration rates between male and female patients was statistically significant (P<0.001). Blood group analysis revealed that 57.9% of the reexplored donors had blood group B+. Bleeding was the primary cause of re-exploration in 73.7% of cases. The majority (57.9%) of re-explorations occurred in patients with operation times between 451-550 minutes.
However, the significant sex disparity and high incidence of bleeding as a cause for re-exploration underscores the need for improved postoperative care.
Conclusion:
This study highlights a relatively low frequency of re-exploration (2.8%) among LDLT donors. However, the significant sex disparity and high incidence of bleeding as a cause for re-exploration underscore the need for improved postoperative care.
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| first_indexed | 2025-02-18T18:40:35Z |
| format | Article |
| id | doaj.art-1cdbfcaf09d847d58eb8c3ebc5ea1bc5 |
| institution | Directory Open Access Journal |
| issn | 2618-0359 2618-0367 |
| language | English |
| last_indexed | 2025-02-18T18:40:35Z |
| publishDate | 2024-09-01 |
| publisher | Frontier Science Associates |
| record_format | Article |
| series | The International Journal of Frontier Sciences |
| spelling | doaj.art-1cdbfcaf09d847d58eb8c3ebc5ea1bc52024-10-20T19:54:36ZengFrontier Science AssociatesThe International Journal of Frontier Sciences2618-03592618-03672024-09-017210.37978/tijfs.v7i1.421Frequency and Risk factors of Reoperation in LDLT DonorsHamid Raza Laghari0Aamir Bashir1Muhammad Akram2Ibrahim Asghar3Usman Ali Rizvi4Sirajuddin5Umar Baloch6Pir Abdul Qadir Shah Jeelani Institute of Medical SciencesPIR ABDUL QADIR SHAH JEELANI INSTITUTE OF MEDICAL SCIENCES,GAMBATPir Abdul Qadir Shah Jeelani Institute of Medical SciencesPir Abdul Qadir Shah Jeelani Institute of Medical SciencesPir Abdul Qadir Shah Jeelani Institute of Medical SciencesPir Abdul Qadir Shah Jeelani Institute of Medical SciencesPir Abdul Qadir Shah Jeelani Institute of Medical Sciences Background: Liver transplantation (LT) is the definitive treatment for end-stage liver disease, acute liver failure, liver tumors, and metabolic diseases. Re-exploration after surgery is associated with poor clinical outcomes and is considered a quality-of-care measure. Objective: To determine the frequency and risk factors of reoperation (early re-laparotomy) after hepatectomy in postoperative LDLT donors. Materials and Methods: A cross-sectional analytical study was conducted at the Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences between December 2023 and May 2024. This study included 672 LDLT donors aged > 18 years old. Data on donor age, sex, blood group, operation time, and re-exploration were collected. The primary endpoints were the frequency and causes of re-exploration, and the secondary endpoints included the association of re-exploration with clinical outcomes. Statistical analyses were performed using SPSS 25.0, with the significance level set at P < 0.05. Blood group analysis revealed that 57.9% of reexplored donors had blood group B+. Results: The frequency of re-exploration was 2.8%. Among those requiring re-exploration, 42.1% were aged 21-28 years. The difference in re-exploration rates between male and female patients was statistically significant (P<0.001). Blood group analysis revealed that 57.9% of the reexplored donors had blood group B+. Bleeding was the primary cause of re-exploration in 73.7% of cases. The majority (57.9%) of re-explorations occurred in patients with operation times between 451-550 minutes. However, the significant sex disparity and high incidence of bleeding as a cause for re-exploration underscores the need for improved postoperative care. Conclusion: This study highlights a relatively low frequency of re-exploration (2.8%) among LDLT donors. However, the significant sex disparity and high incidence of bleeding as a cause for re-exploration underscore the need for improved postoperative care. https://p2024.frontierscienceassociates.com.pk/index.php/tijfs/article/view/195Re-explorationPostoperative complicationsGender disparityOperation time |
| spellingShingle | Hamid Raza Laghari Aamir Bashir Muhammad Akram Ibrahim Asghar Usman Ali Rizvi Sirajuddin Umar Baloch Frequency and Risk factors of Reoperation in LDLT Donors The International Journal of Frontier Sciences Re-exploration Postoperative complications Gender disparity Operation time |
| title | Frequency and Risk factors of Reoperation in LDLT Donors |
| title_full | Frequency and Risk factors of Reoperation in LDLT Donors |
| title_fullStr | Frequency and Risk factors of Reoperation in LDLT Donors |
| title_full_unstemmed | Frequency and Risk factors of Reoperation in LDLT Donors |
| title_short | Frequency and Risk factors of Reoperation in LDLT Donors |
| title_sort | frequency and risk factors of reoperation in ldlt donors |
| topic | Re-exploration Postoperative complications Gender disparity Operation time |
| url | https://p2024.frontierscienceassociates.com.pk/index.php/tijfs/article/view/195 |
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