Efficacy and Safety of Cholera Vaccines
Cholera is an acute diarrheal disease caused by toxigenic strains of Vibrio cholerae O1 and O139 serogroups. It still remains a major global healthcare problem. According to WHO, about 100,000 people die from cholera every year, despite the modern methods of treatment, improvement in the quality o...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products»
2018-03-01
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| Series: | Биопрепараты: Профилактика, диагностика, лечение |
| Subjects: | |
| Online Access: | https://www.biopreparations.ru/jour/article/view/120 |
| Summary: | Cholera is an acute diarrheal disease caused by toxigenic strains of Vibrio cholerae O1 and O139 serogroups. It still remains a major global healthcare problem. According to WHO, about 100,000 people die from cholera every year, despite the modern methods of treatment, improvement in the quality of drinking water, sanitation and hygiene. In recent years, oral cholera vaccines have proved an effective tool for preventing and curbing cholera epidemics. According to the WHO Ending Cholera — A Global Roadmap, mass vaccination should help reduce the mortality resulting from cholera by 90 % worldwide by 2030 and eliminate the disease in 20 countries. The review outlines the main historical stages in the development of cholera vaccines: parenteral, chemical, inactivated and live oral vaccines. The paper compares active ingredients and excipients used in Dukoral®, mORC-VAX®, Shanchol®, Euvichol®, Vaxchora®, Oravacs® and the cholera bivalent chemical vaccine. The results of international multicenter clinical trials of oral inactivated, live and chemical cholera vaccines are analysed. Issues related to efficacy and safety studies of cholera vaccines are considered. |
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| ISSN: | 2221-996X 2619-1156 |