A Comparative Assessment of Biological Effects and Chemical Profile of Italian Asphodeline lutea Extracts
The present study aims to highlight the therapeutic potential of Asphodeline lutea (AL), a wild edible plant of the Mediterranean diet. Roots, aerial parts, and flowers of AL at two different phenological stages were collected from three locations in Italy. The inhibitory activities of extracts on s...
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| Format: | Article |
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MDPI AG
2018-02-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/23/2/461 |
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| author | Dora Melucci Marcello Locatelli Clinio Locatelli Alessandro Zappi Francesco De Laurentiis Simone Carradori Cristina Campestre Lidia Leporini Gokhan Zengin Carene Marie Nancy Picot Luigi Menghini Mohamad Fawzi Mahomoodally |
| author_facet | Dora Melucci Marcello Locatelli Clinio Locatelli Alessandro Zappi Francesco De Laurentiis Simone Carradori Cristina Campestre Lidia Leporini Gokhan Zengin Carene Marie Nancy Picot Luigi Menghini Mohamad Fawzi Mahomoodally |
| author_sort | Dora Melucci |
| collection | DOAJ |
| description | The present study aims to highlight the therapeutic potential of Asphodeline lutea (AL), a wild edible plant of the Mediterranean diet. Roots, aerial parts, and flowers of AL at two different phenological stages were collected from three locations in Italy. The inhibitory activities of extracts on strategic enzymes linked to human diseases were assessed. The antioxidant properties were evaluated in vitro, using six standard bioassays. The phenolic and anthraquinone profiles were also established using HPLC-PDA. Zinc, cadmium, lead, and copper contents were also determined. All the samples inhibited acetylcholinesterase (from 1.51 to 2.20 mg GALAEs/g extract), tyrosinase (from 7.50 to 25.3 mg KAEs/g extract), and α-amylase (from 0.37 to 0.51 mmol ACAEs/g extract). Aloe-emodin and physcion were present in all parts, while rhein was not detected. The phenolic profile and the heavy metals composition of specimens gathered from three different regions of Italy were different. It can be argued that samples collected near the street can contain higher concentrations of heavy metals. The experimental data confirm that the A. lutea species could be considered as a potential source of bioactive metabolites, and its consumption could play a positive and safe role in human health maintenance. |
| first_indexed | 2024-12-14T20:51:39Z |
| format | Article |
| id | doaj.art-1cde7efaa0ab4d359666418753cfd05e |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-14T20:51:39Z |
| publishDate | 2018-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1cde7efaa0ab4d359666418753cfd05e2022-12-21T22:47:48ZengMDPI AGMolecules1420-30492018-02-0123246110.3390/molecules23020461molecules23020461A Comparative Assessment of Biological Effects and Chemical Profile of Italian Asphodeline lutea ExtractsDora Melucci0Marcello Locatelli1Clinio Locatelli2Alessandro Zappi3Francesco De Laurentiis4Simone Carradori5Cristina Campestre6Lidia Leporini7Gokhan Zengin8Carene Marie Nancy Picot9Luigi Menghini10Mohamad Fawzi Mahomoodally11Department of Chemistry “G. Ciamician”, University of Bologna, 40126 Bologna, ItalyDepartment of Pharmacy, University “G. D’Annunzio” of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Chemistry “G. Ciamician”, University of Bologna, 40126 Bologna, ItalyDepartment of Chemistry “G. Ciamician”, University of Bologna, 40126 Bologna, ItalyDepartment of Chemistry “G. Ciamician”, University of Bologna, 40126 Bologna, ItalyDepartment of Pharmacy, University “G. D’Annunzio” of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Pharmacy, University “G. D’Annunzio” of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Pharmacy, University “G. D’Annunzio” of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Biology, Selcuk University, Campus, 42250, 42130 Konya, TurkeyDepartment of Health Sciences, University of Mauritius, Réduit 80837, MauritiusDepartment of Pharmacy, University “G. D’Annunzio” of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Health Sciences, University of Mauritius, Réduit 80837, MauritiusThe present study aims to highlight the therapeutic potential of Asphodeline lutea (AL), a wild edible plant of the Mediterranean diet. Roots, aerial parts, and flowers of AL at two different phenological stages were collected from three locations in Italy. The inhibitory activities of extracts on strategic enzymes linked to human diseases were assessed. The antioxidant properties were evaluated in vitro, using six standard bioassays. The phenolic and anthraquinone profiles were also established using HPLC-PDA. Zinc, cadmium, lead, and copper contents were also determined. All the samples inhibited acetylcholinesterase (from 1.51 to 2.20 mg GALAEs/g extract), tyrosinase (from 7.50 to 25.3 mg KAEs/g extract), and α-amylase (from 0.37 to 0.51 mmol ACAEs/g extract). Aloe-emodin and physcion were present in all parts, while rhein was not detected. The phenolic profile and the heavy metals composition of specimens gathered from three different regions of Italy were different. It can be argued that samples collected near the street can contain higher concentrations of heavy metals. The experimental data confirm that the A. lutea species could be considered as a potential source of bioactive metabolites, and its consumption could play a positive and safe role in human health maintenance.http://www.mdpi.com/1420-3049/23/2/461Asphodeline luteaHPLC-PDAheavy metalstyrosinasediabetesneurodegenerative disease |
| spellingShingle | Dora Melucci Marcello Locatelli Clinio Locatelli Alessandro Zappi Francesco De Laurentiis Simone Carradori Cristina Campestre Lidia Leporini Gokhan Zengin Carene Marie Nancy Picot Luigi Menghini Mohamad Fawzi Mahomoodally A Comparative Assessment of Biological Effects and Chemical Profile of Italian Asphodeline lutea Extracts Molecules Asphodeline lutea HPLC-PDA heavy metals tyrosinase diabetes neurodegenerative disease |
| title | A Comparative Assessment of Biological Effects and Chemical Profile of Italian Asphodeline lutea Extracts |
| title_full | A Comparative Assessment of Biological Effects and Chemical Profile of Italian Asphodeline lutea Extracts |
| title_fullStr | A Comparative Assessment of Biological Effects and Chemical Profile of Italian Asphodeline lutea Extracts |
| title_full_unstemmed | A Comparative Assessment of Biological Effects and Chemical Profile of Italian Asphodeline lutea Extracts |
| title_short | A Comparative Assessment of Biological Effects and Chemical Profile of Italian Asphodeline lutea Extracts |
| title_sort | comparative assessment of biological effects and chemical profile of italian asphodeline lutea extracts |
| topic | Asphodeline lutea HPLC-PDA heavy metals tyrosinase diabetes neurodegenerative disease |
| url | http://www.mdpi.com/1420-3049/23/2/461 |
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