Allium victorialis L. Extracts Promote Activity of FXR to Ameliorate Alcoholic Liver Disease: Targeting Liver Lipid Deposition and Inflammation
Allium victorialis L. (AVL) is a traditional medicinal plant recorded in the Compendium of Materia Medica (the Ming Dynasty). In general, it is used for hemostasis, analgesia, anti-inflammation, antioxidation, and to especially facilitate hepatoprotective effect. In recent years, it has received mor...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.738689/full |
| _version_ | 1819136612372578304 |
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| author | Zhen-Yu Cui Xin Han Yu-Chen Jiang Jia-Yi Dou Kun-Chen Yao Zhong-He Hu Ming-Hui Yuan Xiao-Xue Bao Mei-Jie Zhou Yue Liu Li-Hua Lian Xian Zhang Ji-Xing Nan Ji-Xing Nan Yan-Ling Wu |
| author_facet | Zhen-Yu Cui Xin Han Yu-Chen Jiang Jia-Yi Dou Kun-Chen Yao Zhong-He Hu Ming-Hui Yuan Xiao-Xue Bao Mei-Jie Zhou Yue Liu Li-Hua Lian Xian Zhang Ji-Xing Nan Ji-Xing Nan Yan-Ling Wu |
| author_sort | Zhen-Yu Cui |
| collection | DOAJ |
| description | Allium victorialis L. (AVL) is a traditional medicinal plant recorded in the Compendium of Materia Medica (the Ming Dynasty). In general, it is used for hemostasis, analgesia, anti-inflammation, antioxidation, and to especially facilitate hepatoprotective effect. In recent years, it has received more and more attention due to its special nutritional and medicinal value. The present study investigates the effect and potential mechanism of AVL against alcoholic liver disease (ALD). C57BL/6 mice were fed Lieber–DeCarli liquid diet containing 5% ethanol plus a single ethanol gavage (5 g/kg), and followed up with the administration of AVL or silymarin. AML12 cells were stimulated with ethanol and incubated with AVL. AVL significantly reduced serum transaminase and triglycerides in the liver and attenuated histopathological changes caused by ethanol. AVL significantly inhibited SREBP1 and its target genes, regulated lipin 1/2, increased PPARα and its target genes, and decreased PPARγ expression caused by ethanol. In addition, AVL significantly enhanced FXR, LXRs, Sirt1, and AMPK expressions compared with the EtOH group. AVL also inhibited inflammatory factors, NLRP3, and F4/80 and MPO, macrophage and neutrophil markers. In vitro, AVL significantly reduced lipid droplets, lipid metabolism enzymes, and inflammatory factors depending on FXR activation. AVL could ameliorate alcoholic steatohepatitis, lipid deposition and inflammation in ALD by targeting FXR activation. |
| first_indexed | 2024-12-22T10:37:45Z |
| format | Article |
| id | doaj.art-1cde92d9bc00458d86346173701d16fa |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-22T10:37:45Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-1cde92d9bc00458d86346173701d16fa2022-12-21T18:29:08ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-10-011210.3389/fphar.2021.738689738689Allium victorialis L. Extracts Promote Activity of FXR to Ameliorate Alcoholic Liver Disease: Targeting Liver Lipid Deposition and InflammationZhen-Yu Cui0Xin Han1Yu-Chen Jiang2Jia-Yi Dou3Kun-Chen Yao4Zhong-He Hu5Ming-Hui Yuan6Xiao-Xue Bao7Mei-Jie Zhou8Yue Liu9Li-Hua Lian10Xian Zhang11Ji-Xing Nan12Ji-Xing Nan13Yan-Ling Wu14Key Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, ChinaChinese Medicine Processing Centre, College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, ChinaKey Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, ChinaKey Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, ChinaKey Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, ChinaKey Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, ChinaKey Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, ChinaKey Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, ChinaKey Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, ChinaKey Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, ChinaKey Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, ChinaAgricultural College, Yanbian University, Yanji, ChinaKey Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, ChinaClinical Research Center, Affiliated Hospital of Yanbian University, Yanji, ChinaKey Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, ChinaAllium victorialis L. (AVL) is a traditional medicinal plant recorded in the Compendium of Materia Medica (the Ming Dynasty). In general, it is used for hemostasis, analgesia, anti-inflammation, antioxidation, and to especially facilitate hepatoprotective effect. In recent years, it has received more and more attention due to its special nutritional and medicinal value. The present study investigates the effect and potential mechanism of AVL against alcoholic liver disease (ALD). C57BL/6 mice were fed Lieber–DeCarli liquid diet containing 5% ethanol plus a single ethanol gavage (5 g/kg), and followed up with the administration of AVL or silymarin. AML12 cells were stimulated with ethanol and incubated with AVL. AVL significantly reduced serum transaminase and triglycerides in the liver and attenuated histopathological changes caused by ethanol. AVL significantly inhibited SREBP1 and its target genes, regulated lipin 1/2, increased PPARα and its target genes, and decreased PPARγ expression caused by ethanol. In addition, AVL significantly enhanced FXR, LXRs, Sirt1, and AMPK expressions compared with the EtOH group. AVL also inhibited inflammatory factors, NLRP3, and F4/80 and MPO, macrophage and neutrophil markers. In vitro, AVL significantly reduced lipid droplets, lipid metabolism enzymes, and inflammatory factors depending on FXR activation. AVL could ameliorate alcoholic steatohepatitis, lipid deposition and inflammation in ALD by targeting FXR activation.https://www.frontiersin.org/articles/10.3389/fphar.2021.738689/fullAllium victorialis Lalcoholic liver diseaselipid depositioninflammationfarnesoid X receptor |
| spellingShingle | Zhen-Yu Cui Xin Han Yu-Chen Jiang Jia-Yi Dou Kun-Chen Yao Zhong-He Hu Ming-Hui Yuan Xiao-Xue Bao Mei-Jie Zhou Yue Liu Li-Hua Lian Xian Zhang Ji-Xing Nan Ji-Xing Nan Yan-Ling Wu Allium victorialis L. Extracts Promote Activity of FXR to Ameliorate Alcoholic Liver Disease: Targeting Liver Lipid Deposition and Inflammation Frontiers in Pharmacology Allium victorialis L alcoholic liver disease lipid deposition inflammation farnesoid X receptor |
| title | Allium victorialis L. Extracts Promote Activity of FXR to Ameliorate Alcoholic Liver Disease: Targeting Liver Lipid Deposition and Inflammation |
| title_full | Allium victorialis L. Extracts Promote Activity of FXR to Ameliorate Alcoholic Liver Disease: Targeting Liver Lipid Deposition and Inflammation |
| title_fullStr | Allium victorialis L. Extracts Promote Activity of FXR to Ameliorate Alcoholic Liver Disease: Targeting Liver Lipid Deposition and Inflammation |
| title_full_unstemmed | Allium victorialis L. Extracts Promote Activity of FXR to Ameliorate Alcoholic Liver Disease: Targeting Liver Lipid Deposition and Inflammation |
| title_short | Allium victorialis L. Extracts Promote Activity of FXR to Ameliorate Alcoholic Liver Disease: Targeting Liver Lipid Deposition and Inflammation |
| title_sort | allium victorialis l extracts promote activity of fxr to ameliorate alcoholic liver disease targeting liver lipid deposition and inflammation |
| topic | Allium victorialis L alcoholic liver disease lipid deposition inflammation farnesoid X receptor |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.738689/full |
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