IL-1β and iNOS can drive the asthmatic comorbidities and decrease of lung function in perennial allergic rhinitis children
Abstract Background Allergic asthma and rhinitis (AR) are closely linked, with a significant proportion of AR patients developing asthma. Identification of the early signs of comorbidity of AR and asthma can enable prompt treatment and prevent asthma progression. Objectives and methods This study in...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Allergy, Asthma & Clinical Immunology |
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| Online Access: | https://doi.org/10.1186/s13223-023-00867-3 |
| _version_ | 1797363169630355456 |
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| author | Myung Woul Han Song Hee Kim Inbo Oh Yang ho Kim Jiho Lee |
| author_facet | Myung Woul Han Song Hee Kim Inbo Oh Yang ho Kim Jiho Lee |
| author_sort | Myung Woul Han |
| collection | DOAJ |
| description | Abstract Background Allergic asthma and rhinitis (AR) are closely linked, with a significant proportion of AR patients developing asthma. Identification of the early signs of comorbidity of AR and asthma can enable prompt treatment and prevent asthma progression. Objectives and methods This study investigated the role of interleukin-1β (IL-1β), a pro-inflammatory cytokine, and inducible nitric oxide synthase (iNOS) in the comorbidity of AR and asthma and lung function in Korean children with perennial AR (PAR). A cohort of 240 subjects (6 to 10 years old) with PAR (PAR alone: 113 children, PAR and asthma: 127 children) was analyzed for various biomarkers, including IL-1β, iNOS, and epithelial-mesenchymal transition (EMT) markers in serum. The blood levels of eosinophils and immunoglobulin E (IgE) were examined. IL-1β, CCL-24, E-cadherin, and vimentin were measured by enzyme-linked immunosorbent assay (ELISA). Epithelial iNOS was measured by the NOS kit. Results Elevated levels of IL-1β, iNOS, and vimentin in the serum were identified as significant indicators of the likelihood of comorbidity of PAR and asthma in children. Furthermore, higher concentrations of IL-1β, iNOS, and vimentin have been linked to reduced lung function in PAR children. Notably, IL-1β expression shows a relationship with the levels of E-cadherin, vimentin, and CCL-24. However, no correlation was found between IL-1β and iNOS expressions. Conclusions This study suggests that IL-1β and iNOS can be biomarkers in the progression of PAR and asthma and decreased lung function, suggesting potential targets for early intervention and treatment. |
| first_indexed | 2024-03-08T16:17:02Z |
| format | Article |
| id | doaj.art-1cdf4b73cfc0441e81439f2c39cf68e7 |
| institution | Directory Open Access Journal |
| issn | 1710-1492 |
| language | English |
| last_indexed | 2024-03-08T16:17:02Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Allergy, Asthma & Clinical Immunology |
| spelling | doaj.art-1cdf4b73cfc0441e81439f2c39cf68e72024-01-07T12:30:41ZengBMCAllergy, Asthma & Clinical Immunology1710-14922024-01-012011710.1186/s13223-023-00867-3IL-1β and iNOS can drive the asthmatic comorbidities and decrease of lung function in perennial allergic rhinitis childrenMyung Woul Han0Song Hee Kim1Inbo Oh2Yang ho Kim3Jiho Lee4Department of Otolaryngology, Ulsan University Hospital, University of Ulsan College of MedicineDepartment of Otolaryngology, Ulsan University Hospital, University of Ulsan College of MedicineEnvironmental Health Center, University of Ulsan College of MedicineDepartment of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of MedicineDepartment of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of MedicineAbstract Background Allergic asthma and rhinitis (AR) are closely linked, with a significant proportion of AR patients developing asthma. Identification of the early signs of comorbidity of AR and asthma can enable prompt treatment and prevent asthma progression. Objectives and methods This study investigated the role of interleukin-1β (IL-1β), a pro-inflammatory cytokine, and inducible nitric oxide synthase (iNOS) in the comorbidity of AR and asthma and lung function in Korean children with perennial AR (PAR). A cohort of 240 subjects (6 to 10 years old) with PAR (PAR alone: 113 children, PAR and asthma: 127 children) was analyzed for various biomarkers, including IL-1β, iNOS, and epithelial-mesenchymal transition (EMT) markers in serum. The blood levels of eosinophils and immunoglobulin E (IgE) were examined. IL-1β, CCL-24, E-cadherin, and vimentin were measured by enzyme-linked immunosorbent assay (ELISA). Epithelial iNOS was measured by the NOS kit. Results Elevated levels of IL-1β, iNOS, and vimentin in the serum were identified as significant indicators of the likelihood of comorbidity of PAR and asthma in children. Furthermore, higher concentrations of IL-1β, iNOS, and vimentin have been linked to reduced lung function in PAR children. Notably, IL-1β expression shows a relationship with the levels of E-cadherin, vimentin, and CCL-24. However, no correlation was found between IL-1β and iNOS expressions. Conclusions This study suggests that IL-1β and iNOS can be biomarkers in the progression of PAR and asthma and decreased lung function, suggesting potential targets for early intervention and treatment.https://doi.org/10.1186/s13223-023-00867-3Allergic rhinitisAsthmaComorbidityIL-1βiNOSEpithelial-mesenchymal transition |
| spellingShingle | Myung Woul Han Song Hee Kim Inbo Oh Yang ho Kim Jiho Lee IL-1β and iNOS can drive the asthmatic comorbidities and decrease of lung function in perennial allergic rhinitis children Allergy, Asthma & Clinical Immunology Allergic rhinitis Asthma Comorbidity IL-1β iNOS Epithelial-mesenchymal transition |
| title | IL-1β and iNOS can drive the asthmatic comorbidities and decrease of lung function in perennial allergic rhinitis children |
| title_full | IL-1β and iNOS can drive the asthmatic comorbidities and decrease of lung function in perennial allergic rhinitis children |
| title_fullStr | IL-1β and iNOS can drive the asthmatic comorbidities and decrease of lung function in perennial allergic rhinitis children |
| title_full_unstemmed | IL-1β and iNOS can drive the asthmatic comorbidities and decrease of lung function in perennial allergic rhinitis children |
| title_short | IL-1β and iNOS can drive the asthmatic comorbidities and decrease of lung function in perennial allergic rhinitis children |
| title_sort | il 1β and inos can drive the asthmatic comorbidities and decrease of lung function in perennial allergic rhinitis children |
| topic | Allergic rhinitis Asthma Comorbidity IL-1β iNOS Epithelial-mesenchymal transition |
| url | https://doi.org/10.1186/s13223-023-00867-3 |
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