Pref-1, a Gatekeeper of Adipogenesis
Preadipocyte factor 1 (Pref-1, also called Dlk1/ FA1) is a molecular gatekeeper of adipogenesis by maintaining preadipocyte state and preventing adipocyte differentiation. Pref-1 is made as an epidermal growth factor-like repeat containing transmembrane protein, and is cleaved by TNFα-converting enz...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-07-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2013.00079/full |
| _version_ | 1818199547442102272 |
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| author | Carolyn S Hudak Hei Sook eSul |
| author_facet | Carolyn S Hudak Hei Sook eSul |
| author_sort | Carolyn S Hudak |
| collection | DOAJ |
| description | Preadipocyte factor 1 (Pref-1, also called Dlk1/ FA1) is a molecular gatekeeper of adipogenesis by maintaining preadipocyte state and preventing adipocyte differentiation. Pref-1 is made as an epidermal growth factor-like repeat containing transmembrane protein, and is cleaved by TNFα-converting enzyme (TACE) to generate a soluble form, which acts as an autocrine/paracrine factor. Pref-1 upregulates Sox9 expression by activating the ERK/MAPK pathway and the Pref-1 interaction with fibronectin is required for inhibition of adipogenesis. Pref-1 also prevents brown adipocyte differentiation and its thermogenic function. Here, we highlight the recent evidence for the role of Pref-1 in adipogenesis. |
| first_indexed | 2024-12-12T02:23:30Z |
| format | Article |
| id | doaj.art-1ce1f2526ce74b96ac1cbb7bec4e7164 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-12T02:23:30Z |
| publishDate | 2013-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-1ce1f2526ce74b96ac1cbb7bec4e71642022-12-22T00:41:37ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922013-07-01410.3389/fendo.2013.0007954800Pref-1, a Gatekeeper of AdipogenesisCarolyn S Hudak0Hei Sook eSul1University of California, BerkeleyUniversity of California, BerkeleyPreadipocyte factor 1 (Pref-1, also called Dlk1/ FA1) is a molecular gatekeeper of adipogenesis by maintaining preadipocyte state and preventing adipocyte differentiation. Pref-1 is made as an epidermal growth factor-like repeat containing transmembrane protein, and is cleaved by TNFα-converting enzyme (TACE) to generate a soluble form, which acts as an autocrine/paracrine factor. Pref-1 upregulates Sox9 expression by activating the ERK/MAPK pathway and the Pref-1 interaction with fibronectin is required for inhibition of adipogenesis. Pref-1 also prevents brown adipocyte differentiation and its thermogenic function. Here, we highlight the recent evidence for the role of Pref-1 in adipogenesis.http://journal.frontiersin.org/Journal/10.3389/fendo.2013.00079/fullAdipogenesisSOX9 Transcription FactorBrown FatfibronectinProgenitorsPref-1 |
| spellingShingle | Carolyn S Hudak Hei Sook eSul Pref-1, a Gatekeeper of Adipogenesis Frontiers in Endocrinology Adipogenesis SOX9 Transcription Factor Brown Fat fibronectin Progenitors Pref-1 |
| title | Pref-1, a Gatekeeper of Adipogenesis |
| title_full | Pref-1, a Gatekeeper of Adipogenesis |
| title_fullStr | Pref-1, a Gatekeeper of Adipogenesis |
| title_full_unstemmed | Pref-1, a Gatekeeper of Adipogenesis |
| title_short | Pref-1, a Gatekeeper of Adipogenesis |
| title_sort | pref 1 a gatekeeper of adipogenesis |
| topic | Adipogenesis SOX9 Transcription Factor Brown Fat fibronectin Progenitors Pref-1 |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2013.00079/full |
| work_keys_str_mv | AT carolynshudak pref1agatekeeperofadipogenesis AT heisookesul pref1agatekeeperofadipogenesis |