The impact of geometry, intramural friction, and pressure on the antegrade longitudinal motion of the arterial wall: A phantom and finite element study
Abstract Longitudinal motion of the carotid arterial wall, as measured with ultrasound, has shown promise as an indicator of vascular health. The underlying mechanisms are however not fully understood. We have found, in in vivo studies, that blood pressure has a strong relation to the antegrade long...
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| Format: | Article |
| Language: | English |
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Wiley
2023-06-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.15746 |
| _version_ | 1797397329532157952 |
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| author | Sandra Sjöstrand Alice Widerström Ingrid Svensson Patrick Segers Tobias Erlöv Åsa Rydén Ahlgren Magnus Cinthio |
| author_facet | Sandra Sjöstrand Alice Widerström Ingrid Svensson Patrick Segers Tobias Erlöv Åsa Rydén Ahlgren Magnus Cinthio |
| author_sort | Sandra Sjöstrand |
| collection | DOAJ |
| description | Abstract Longitudinal motion of the carotid arterial wall, as measured with ultrasound, has shown promise as an indicator of vascular health. The underlying mechanisms are however not fully understood. We have found, in in vivo studies, that blood pressure has a strong relation to the antegrade longitudinal displacement in early systole. Further, we have identified that a tapered geometry and the intramural friction in‐between two parts of a vessel wall influence the longitudinal displacement. We therefore studied the interaction between pressure, vessel geometry and intramural friction, tapered and straight ultrasound phantoms in a paralleled hydraulic bench study and corresponding numerical models. Profound antegrade longitudinal motion was induced in the innermost part of both tapered phantoms and the numerical models, but to a lesser extent when intramural friction was increased in the simulations. Strong correlations (R = 0.82–0.96; p < 1e‐3; k = 9.3–14 μm/mmHg) between longitudinal displacement and pulse pressure were found in six of seven regions of interest in tapered phantoms. The motion of the straight phantom and the corresponding numerical model was smaller, on average zero or close to zero. This study demonstrates that tapering of the lumen, low intramural friction, and pressure might be important conducive features to the antegrade longitudinal motion of the arterial wall in vivo. |
| first_indexed | 2024-03-09T01:08:19Z |
| format | Article |
| id | doaj.art-1ce2eb2f96e04e8999d2fba9fb01b571 |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-03-09T01:08:19Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-1ce2eb2f96e04e8999d2fba9fb01b5712023-12-11T09:06:36ZengWileyPhysiological Reports2051-817X2023-06-011112n/an/a10.14814/phy2.15746The impact of geometry, intramural friction, and pressure on the antegrade longitudinal motion of the arterial wall: A phantom and finite element studySandra Sjöstrand0Alice Widerström1Ingrid Svensson2Patrick Segers3Tobias Erlöv4Åsa Rydén Ahlgren5Magnus Cinthio6Department of Biomedical Engineering, Faculty of Engineering Lund University Lund SwedenDepartment of Biomedical Engineering, Faculty of Engineering Lund University Lund SwedenDepartment of Biomedical Engineering, Faculty of Engineering Lund University Lund SwedenIBiTech‐bioMMeda Ghent University Ghent BelgiumDepartment of Biomedical Engineering, Faculty of Engineering Lund University Lund SwedenDepartment of Translational Medicine Lund University Lund SwedenDepartment of Biomedical Engineering, Faculty of Engineering Lund University Lund SwedenAbstract Longitudinal motion of the carotid arterial wall, as measured with ultrasound, has shown promise as an indicator of vascular health. The underlying mechanisms are however not fully understood. We have found, in in vivo studies, that blood pressure has a strong relation to the antegrade longitudinal displacement in early systole. Further, we have identified that a tapered geometry and the intramural friction in‐between two parts of a vessel wall influence the longitudinal displacement. We therefore studied the interaction between pressure, vessel geometry and intramural friction, tapered and straight ultrasound phantoms in a paralleled hydraulic bench study and corresponding numerical models. Profound antegrade longitudinal motion was induced in the innermost part of both tapered phantoms and the numerical models, but to a lesser extent when intramural friction was increased in the simulations. Strong correlations (R = 0.82–0.96; p < 1e‐3; k = 9.3–14 μm/mmHg) between longitudinal displacement and pulse pressure were found in six of seven regions of interest in tapered phantoms. The motion of the straight phantom and the corresponding numerical model was smaller, on average zero or close to zero. This study demonstrates that tapering of the lumen, low intramural friction, and pressure might be important conducive features to the antegrade longitudinal motion of the arterial wall in vivo.https://doi.org/10.14814/phy2.15746arteryfinite element modelinglongitudinal displacementshear stressultrasound |
| spellingShingle | Sandra Sjöstrand Alice Widerström Ingrid Svensson Patrick Segers Tobias Erlöv Åsa Rydén Ahlgren Magnus Cinthio The impact of geometry, intramural friction, and pressure on the antegrade longitudinal motion of the arterial wall: A phantom and finite element study Physiological Reports artery finite element modeling longitudinal displacement shear stress ultrasound |
| title | The impact of geometry, intramural friction, and pressure on the antegrade longitudinal motion of the arterial wall: A phantom and finite element study |
| title_full | The impact of geometry, intramural friction, and pressure on the antegrade longitudinal motion of the arterial wall: A phantom and finite element study |
| title_fullStr | The impact of geometry, intramural friction, and pressure on the antegrade longitudinal motion of the arterial wall: A phantom and finite element study |
| title_full_unstemmed | The impact of geometry, intramural friction, and pressure on the antegrade longitudinal motion of the arterial wall: A phantom and finite element study |
| title_short | The impact of geometry, intramural friction, and pressure on the antegrade longitudinal motion of the arterial wall: A phantom and finite element study |
| title_sort | impact of geometry intramural friction and pressure on the antegrade longitudinal motion of the arterial wall a phantom and finite element study |
| topic | artery finite element modeling longitudinal displacement shear stress ultrasound |
| url | https://doi.org/10.14814/phy2.15746 |
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