Exosome-mediated effects and applications in inflammatory diseases of the digestive system
Abstract Exosomes are membranous vesicles containing RNA and proteins that are specifically secreted in vivo. Exosomes have many functions, such as material transport and signal transduction between cells. Many studies have proven that exosomes can not only be used as biomarkers for disease diagnosi...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-022-00792-y |
| _version_ | 1817993953081819136 |
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| author | Xianli Wu Xiaolin Xu Yiwei Xiang Dongdong Fan Qiming An Gengyu Yue Zhe Jin Jianhong Ding Yanxia Hu Qian Du Jingyu Xu Rui Xie |
| author_facet | Xianli Wu Xiaolin Xu Yiwei Xiang Dongdong Fan Qiming An Gengyu Yue Zhe Jin Jianhong Ding Yanxia Hu Qian Du Jingyu Xu Rui Xie |
| author_sort | Xianli Wu |
| collection | DOAJ |
| description | Abstract Exosomes are membranous vesicles containing RNA and proteins that are specifically secreted in vivo. Exosomes have many functions, such as material transport and signal transduction between cells. Many studies have proven that exosomes can not only be used as biomarkers for disease diagnosis but also as carriers to transmit information between cells. Exosomes participate in a variety of physiological and pathological processes, including the immune response, antigen presentation, cell migration, cell differentiation, and tumour development. Differences in exosome functions depend on cell type. In recent years, exosome origin, cargo composition, and precise regulatory mechanisms have been the focus of research. Although exosomes have been extensively reported in digestive tumours, few articles have reviewed their roles in inflammatory diseases of the digestive system, especially inflammatory-related diseases (such as reflux oesophagitis, gastritis, inflammatory bowel disease, hepatitis, and pancreatitis). This paper briefly summarizes the roles of exosomes in inflammatory diseases of the digestive system to provide a basis for research on the mechanism of inflammatory diseases of the digestive system targeted by exosomes. |
| first_indexed | 2024-04-14T01:46:37Z |
| format | Article |
| id | doaj.art-1ce3cd2f6ad94389af2402da5b835c5e |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-04-14T01:46:37Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-1ce3cd2f6ad94389af2402da5b835c5e2022-12-22T02:19:31ZengBMCEuropean Journal of Medical Research2047-783X2022-08-0127111310.1186/s40001-022-00792-yExosome-mediated effects and applications in inflammatory diseases of the digestive systemXianli Wu0Xiaolin Xu1Yiwei Xiang2Dongdong Fan3Qiming An4Gengyu Yue5Zhe Jin6Jianhong Ding7Yanxia Hu8Qian Du9Jingyu Xu10Rui Xie11Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical UniversityDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical UniversityDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical UniversityDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical UniversityDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical UniversityDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical UniversityDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical UniversityDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical UniversityDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical UniversityDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical UniversityDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical UniversityDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical UniversityAbstract Exosomes are membranous vesicles containing RNA and proteins that are specifically secreted in vivo. Exosomes have many functions, such as material transport and signal transduction between cells. Many studies have proven that exosomes can not only be used as biomarkers for disease diagnosis but also as carriers to transmit information between cells. Exosomes participate in a variety of physiological and pathological processes, including the immune response, antigen presentation, cell migration, cell differentiation, and tumour development. Differences in exosome functions depend on cell type. In recent years, exosome origin, cargo composition, and precise regulatory mechanisms have been the focus of research. Although exosomes have been extensively reported in digestive tumours, few articles have reviewed their roles in inflammatory diseases of the digestive system, especially inflammatory-related diseases (such as reflux oesophagitis, gastritis, inflammatory bowel disease, hepatitis, and pancreatitis). This paper briefly summarizes the roles of exosomes in inflammatory diseases of the digestive system to provide a basis for research on the mechanism of inflammatory diseases of the digestive system targeted by exosomes.https://doi.org/10.1186/s40001-022-00792-yExosomesEsophagitisGastritisInflammatory bowel disease HepatitisPancreatitis |
| spellingShingle | Xianli Wu Xiaolin Xu Yiwei Xiang Dongdong Fan Qiming An Gengyu Yue Zhe Jin Jianhong Ding Yanxia Hu Qian Du Jingyu Xu Rui Xie Exosome-mediated effects and applications in inflammatory diseases of the digestive system European Journal of Medical Research Exosomes Esophagitis Gastritis Inflammatory bowel disease Hepatitis Pancreatitis |
| title | Exosome-mediated effects and applications in inflammatory diseases of the digestive system |
| title_full | Exosome-mediated effects and applications in inflammatory diseases of the digestive system |
| title_fullStr | Exosome-mediated effects and applications in inflammatory diseases of the digestive system |
| title_full_unstemmed | Exosome-mediated effects and applications in inflammatory diseases of the digestive system |
| title_short | Exosome-mediated effects and applications in inflammatory diseases of the digestive system |
| title_sort | exosome mediated effects and applications in inflammatory diseases of the digestive system |
| topic | Exosomes Esophagitis Gastritis Inflammatory bowel disease Hepatitis Pancreatitis |
| url | https://doi.org/10.1186/s40001-022-00792-y |
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