A Noradrenergic Lesion Attenuates Surgery-Induced Cognitive Impairment in Rats by Suppressing Neuroinflammation

A Noradrenergic Lesion Attenuates Surgery-Induced Cognitive Impairment in Rats by Suppressing Neuroinflammation

Postoperative cognitive dysfunction (POCD) is a common postoperative neurocognitive complication in elderly patients. However, the specific pathogenesis is unknown, and it has been demonstrated that neuroinflammation plays a key role in POCD. Recently, increasing evidence has proven that the locus c...

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Bibliographic Details
Main Authors: Jiayu Wang, Ying Zhou, Ke Li, Xiaofeng Li, Meimei Guo, Mian Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
postoperative dysfunction
locus coeruleus noradrenergic system
neuroinflammation
DSP-4
microglia
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.752838/full

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