The Clinical Impact of Platelets on Post-Injury Serum Creatinine Concentration in Multiple Trauma Patients: A Retrospective Cohort Study
<i>Background and objective</i>: Platelets contribute to the immunological response after multiple trauma. To determine the clinical impact, this study analyzes the association between platelets and creatinine concentration as an indicator of kidney function in polytraumatized patients....
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MDPI AG
2022-07-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/7/901 |
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| author | Frederik Greve Ina Aulbach Olivia Mair Peter Biberthaler Marc Hanschen |
| author_facet | Frederik Greve Ina Aulbach Olivia Mair Peter Biberthaler Marc Hanschen |
| author_sort | Frederik Greve |
| collection | DOAJ |
| description | <i>Background and objective</i>: Platelets contribute to the immunological response after multiple trauma. To determine the clinical impact, this study analyzes the association between platelets and creatinine concentration as an indicator of kidney function in polytraumatized patients. <i>Methods:</i> We investigated all patients presenting an Injury Severity Score (ISS) ≥16 for a 2-year period at our trauma center. Platelet counts and creatinine concentrations were analyzed, and correlation analysis was performed within 10 days after multiple trauma. <i>Results</i>: 83 patients with a median ISS of 22 were included. Platelet count was decreased on day 3 (<i>p</i> ≤ 0.001) and increased on day 10 (<i>p</i> ≤ 0.001). Platelet count was elevated on day 10 in younger patients and diminished in severely injured patients (ISS ≥35) on day 1 (<i>p</i> = 0.012) and day 3 (<i>p</i> = 0.011). Creatinine concentration was decreased on day 1 (<i>p</i> = 0.003) and day 10 (<i>p</i> ≤ 0.001) in female patients. Age (<i>p</i> = 0.01), male sex (<i>p</i> = 0.004), and injury severity (<i>p</i> = 0.014) were identified as factors for increased creatinine concentration on day 1, whereas platelets (<i>p</i> = 0.046) were associated with decreased creatinine concentrations on day 5 after multiple trauma. <i>Conclusions</i>: Kinetics of platelet count and creatinine concentration are influenced by age, gender, and trauma severity. There was no clear correlation between platelet counts and creatinine concentration. However, platelets seem to have a modulating effect on creatinine concentrations in the vulnerable phase after trauma. |
| first_indexed | 2024-03-09T06:14:21Z |
| format | Article |
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| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T06:14:21Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-1ce527b582e64ce6893328f3bf74264f2023-12-03T11:54:39ZengMDPI AGMedicina1010-660X1648-91442022-07-0158790110.3390/medicina58070901The Clinical Impact of Platelets on Post-Injury Serum Creatinine Concentration in Multiple Trauma Patients: A Retrospective Cohort StudyFrederik Greve0Ina Aulbach1Olivia Mair2Peter Biberthaler3Marc Hanschen4Department of Trauma Surgery, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, GermanyDepartment of Trauma Surgery, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, GermanyDepartment of Trauma Surgery, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, GermanyDepartment of Trauma Surgery, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, GermanyDepartment of Trauma Surgery, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany<i>Background and objective</i>: Platelets contribute to the immunological response after multiple trauma. To determine the clinical impact, this study analyzes the association between platelets and creatinine concentration as an indicator of kidney function in polytraumatized patients. <i>Methods:</i> We investigated all patients presenting an Injury Severity Score (ISS) ≥16 for a 2-year period at our trauma center. Platelet counts and creatinine concentrations were analyzed, and correlation analysis was performed within 10 days after multiple trauma. <i>Results</i>: 83 patients with a median ISS of 22 were included. Platelet count was decreased on day 3 (<i>p</i> ≤ 0.001) and increased on day 10 (<i>p</i> ≤ 0.001). Platelet count was elevated on day 10 in younger patients and diminished in severely injured patients (ISS ≥35) on day 1 (<i>p</i> = 0.012) and day 3 (<i>p</i> = 0.011). Creatinine concentration was decreased on day 1 (<i>p</i> = 0.003) and day 10 (<i>p</i> ≤ 0.001) in female patients. Age (<i>p</i> = 0.01), male sex (<i>p</i> = 0.004), and injury severity (<i>p</i> = 0.014) were identified as factors for increased creatinine concentration on day 1, whereas platelets (<i>p</i> = 0.046) were associated with decreased creatinine concentrations on day 5 after multiple trauma. <i>Conclusions</i>: Kinetics of platelet count and creatinine concentration are influenced by age, gender, and trauma severity. There was no clear correlation between platelet counts and creatinine concentration. However, platelets seem to have a modulating effect on creatinine concentrations in the vulnerable phase after trauma.https://www.mdpi.com/1648-9144/58/7/901plateletscreatininemultiple traumaimmune systemhyperinflammationpost-traumatic organ failure |
| spellingShingle | Frederik Greve Ina Aulbach Olivia Mair Peter Biberthaler Marc Hanschen The Clinical Impact of Platelets on Post-Injury Serum Creatinine Concentration in Multiple Trauma Patients: A Retrospective Cohort Study Medicina platelets creatinine multiple trauma immune system hyperinflammation post-traumatic organ failure |
| title | The Clinical Impact of Platelets on Post-Injury Serum Creatinine Concentration in Multiple Trauma Patients: A Retrospective Cohort Study |
| title_full | The Clinical Impact of Platelets on Post-Injury Serum Creatinine Concentration in Multiple Trauma Patients: A Retrospective Cohort Study |
| title_fullStr | The Clinical Impact of Platelets on Post-Injury Serum Creatinine Concentration in Multiple Trauma Patients: A Retrospective Cohort Study |
| title_full_unstemmed | The Clinical Impact of Platelets on Post-Injury Serum Creatinine Concentration in Multiple Trauma Patients: A Retrospective Cohort Study |
| title_short | The Clinical Impact of Platelets on Post-Injury Serum Creatinine Concentration in Multiple Trauma Patients: A Retrospective Cohort Study |
| title_sort | clinical impact of platelets on post injury serum creatinine concentration in multiple trauma patients a retrospective cohort study |
| topic | platelets creatinine multiple trauma immune system hyperinflammation post-traumatic organ failure |
| url | https://www.mdpi.com/1648-9144/58/7/901 |
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