Localized Talaromyces marneffei infection presenting as a tonsillar mass mimicking malignancy
Talaromyces marneffei is an opportunistic fungal infection seen in immunocompromised patients including those with HIV/AIDS. It is usually seen in patients who live in or are from tropical Asia. In HIV patients, oropharyngeal and laryngeal lesions are usually part of disseminated infection. We descr...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | IDCases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214250920301323 |
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| author | Annapoorna Singh Sarah Atallah Ahmad Al-Shyoukh Matthew DaCunha Masako Mizusawa |
| author_facet | Annapoorna Singh Sarah Atallah Ahmad Al-Shyoukh Matthew DaCunha Masako Mizusawa |
| author_sort | Annapoorna Singh |
| collection | DOAJ |
| description | Talaromyces marneffei is an opportunistic fungal infection seen in immunocompromised patients including those with HIV/AIDS. It is usually seen in patients who live in or are from tropical Asia. In HIV patients, oropharyngeal and laryngeal lesions are usually part of disseminated infection. We describe a case of 63-year-old Vietnamese male with history of HIV/AIDS who presented with localized T. marneffei tonsillar infection without disseminated disease. Imaging studies showed a right tonsillar mass with right cervical lymphadenopathy which was initially thought to be malignancy. The patient underwent biopsy of the mass and histology showed noncaseating granulomas on hematoxylin and eosin stain as well as yeast on Grocott methenamine silver stain. Fungal culture of the biopsy specimen grew suede-like grayish-white colonies with diffuse underlying deep red color pigment which was identified as Talaromyces marneffei. The patient was treated with intravenous liposomal amphotericin B and achieved resolution of symptoms and tonsillar mass. In HIV/AIDS patients who are either from endemic regions or with history of travel to endemic areas particularly Southeast Asia and China, T. marneffei infection should be considered in differential diagnoses of a tonsillar mass. |
| first_indexed | 2024-12-13T20:15:16Z |
| format | Article |
| id | doaj.art-1ce52df1f5f442668d8ceb4b01267abc |
| institution | Directory Open Access Journal |
| issn | 2214-2509 |
| language | English |
| last_indexed | 2024-12-13T20:15:16Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IDCases |
| spelling | doaj.art-1ce52df1f5f442668d8ceb4b01267abc2022-12-21T23:32:49ZengElsevierIDCases2214-25092020-01-0121e00824Localized Talaromyces marneffei infection presenting as a tonsillar mass mimicking malignancyAnnapoorna Singh0Sarah Atallah1Ahmad Al-Shyoukh2Matthew DaCunha3Masako Mizusawa4Department of Internal Medicine, University of Missouri Kansas City, Kansas City, MO, United StatesUniversity of Missouri Kansas City School of Medicine, Kansas City, MO, United StatesDepartment of Internal Medicine, University of Missouri Kansas City, Kansas City, MO, United StatesDepartment of Internal Medicine, University of Missouri Kansas City, Kansas City, MO, United StatesSection of Infectious Diseases, Department of Internal Medicine, University of Missouri Kansas City, Kansas City, MO, United States; Corresponding author at: Section of Infectious Diseases, Department of Internal Medicine, University of Missouri Kansas City, 2301 Holmes Street, Kansas City, MO 64108, United States.Talaromyces marneffei is an opportunistic fungal infection seen in immunocompromised patients including those with HIV/AIDS. It is usually seen in patients who live in or are from tropical Asia. In HIV patients, oropharyngeal and laryngeal lesions are usually part of disseminated infection. We describe a case of 63-year-old Vietnamese male with history of HIV/AIDS who presented with localized T. marneffei tonsillar infection without disseminated disease. Imaging studies showed a right tonsillar mass with right cervical lymphadenopathy which was initially thought to be malignancy. The patient underwent biopsy of the mass and histology showed noncaseating granulomas on hematoxylin and eosin stain as well as yeast on Grocott methenamine silver stain. Fungal culture of the biopsy specimen grew suede-like grayish-white colonies with diffuse underlying deep red color pigment which was identified as Talaromyces marneffei. The patient was treated with intravenous liposomal amphotericin B and achieved resolution of symptoms and tonsillar mass. In HIV/AIDS patients who are either from endemic regions or with history of travel to endemic areas particularly Southeast Asia and China, T. marneffei infection should be considered in differential diagnoses of a tonsillar mass.http://www.sciencedirect.com/science/article/pii/S2214250920301323Talaromyces marneffeiHIVOpportunistic infectionTonsillar massOral lesion |
| spellingShingle | Annapoorna Singh Sarah Atallah Ahmad Al-Shyoukh Matthew DaCunha Masako Mizusawa Localized Talaromyces marneffei infection presenting as a tonsillar mass mimicking malignancy IDCases Talaromyces marneffei HIV Opportunistic infection Tonsillar mass Oral lesion |
| title | Localized Talaromyces marneffei infection presenting as a tonsillar mass mimicking malignancy |
| title_full | Localized Talaromyces marneffei infection presenting as a tonsillar mass mimicking malignancy |
| title_fullStr | Localized Talaromyces marneffei infection presenting as a tonsillar mass mimicking malignancy |
| title_full_unstemmed | Localized Talaromyces marneffei infection presenting as a tonsillar mass mimicking malignancy |
| title_short | Localized Talaromyces marneffei infection presenting as a tonsillar mass mimicking malignancy |
| title_sort | localized talaromyces marneffei infection presenting as a tonsillar mass mimicking malignancy |
| topic | Talaromyces marneffei HIV Opportunistic infection Tonsillar mass Oral lesion |
| url | http://www.sciencedirect.com/science/article/pii/S2214250920301323 |
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