Perinatal Management of Bart's Hemoglobinopathy: Paradoxical Effects of Intrauterine, Transplacental, and Partial Exchange Transfusions

We describe a fetus at 24 3/7 weeks' gestation that showed ultrasound evidence of anemia, hydrops, and severe growth restriction. Both parents were known to be cis heterozygous carriers for SEA α-thalassemia deletion (αα/–). Cordocentesis confirmed fetal anemia and homozygous α-thalassemia (−/−...

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Bibliographic Details
Main Authors: Mark Curran, Michel Mikhael, Wang-Dar Sun, Jina Lim, Anna Leung, Gira Morchi, Ramen H. Chmait
Format: Article
Language:English
Published: Thieme Medical Publishers, Inc. 2020-01-01
Series:American Journal of Perinatology Reports
Subjects:
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-3401799