Obesity, Impaired Glucose Metabolism and Hepatic Histopathological Damage in 3xTg-AD Mice at Different Stages of Disease Compared to Mice with Normal Aging
The crosstalk between obesity, diabetes, steatohepatitis, and dementia creates a controversial scenario when also studied using animal models. In the present work, this crosstalk was investigated in male and female 3xTg-AD mice for Alzheimer’s disease (AD) at different ages/stages and compared to se...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Biology and Life Sciences Forum |
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| Online Access: | https://www.mdpi.com/2673-9976/19/1/10 |
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| author | Clara Pérez-Gozalbo Lydia Giménez-Llort |
| author_facet | Clara Pérez-Gozalbo Lydia Giménez-Llort |
| author_sort | Clara Pérez-Gozalbo |
| collection | DOAJ |
| description | The crosstalk between obesity, diabetes, steatohepatitis, and dementia creates a controversial scenario when also studied using animal models. In the present work, this crosstalk was investigated in male and female 3xTg-AD mice for Alzheimer’s disease (AD) at different ages/stages and compared to sex- and age-matched counterparts with normal aging. The relevance of the genetic background and classical intrinsic factors (AD genotype and sex) were determined using a retrospective analysis of population data and an experimental design. Age/stage of disease was considered a source of stochastic and non-stochastic factors. Data from two different colonies of 3xTg-AD mice with distinct genetic backgrounds were analyzed to verify the functional interplay between the studied factors. Data from asymptomatic/prodromal to early/advanced stages of the disease were screened. Then, all factors’ relationships were studied in an experimental design using the same set of animals. The population data unveiled that the genetic background and sex effects were confirmed with regards to the variable body weight, with changes during disease development and progress. Sexual dimorphism was found as an important factor in glucose metabolism. Statistically significant differences in glucose tolerance and behavioral assessment (exploration, anxiety, and cognition in a two-days open-field paradigm) were found when all the factors were analyzed. In summary, the present study shows that all the studied factors should always be considered when assessing the outcome of the research interventions in the field because they have a distinct functional interplay through the process of normal and AD-pathological aging and from a gendered perspective. |
| first_indexed | 2024-03-11T02:40:27Z |
| format | Article |
| id | doaj.art-1ce89384a83e4911b2e3939f4d65a038 |
| institution | Directory Open Access Journal |
| issn | 2673-9976 |
| language | English |
| last_indexed | 2024-03-11T02:40:27Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology and Life Sciences Forum |
| spelling | doaj.art-1ce89384a83e4911b2e3939f4d65a0382023-11-18T09:35:10ZengMDPI AGBiology and Life Sciences Forum2673-99762022-09-011911010.3390/IECBS2022-12938Obesity, Impaired Glucose Metabolism and Hepatic Histopathological Damage in 3xTg-AD Mice at Different Stages of Disease Compared to Mice with Normal AgingClara Pérez-Gozalbo0Lydia Giménez-Llort1Institut de Neurociències, Universitat Autònoma de Barcelona, 08193 Barcelona, SpainInstitut de Neurociències, Universitat Autònoma de Barcelona, 08193 Barcelona, SpainThe crosstalk between obesity, diabetes, steatohepatitis, and dementia creates a controversial scenario when also studied using animal models. In the present work, this crosstalk was investigated in male and female 3xTg-AD mice for Alzheimer’s disease (AD) at different ages/stages and compared to sex- and age-matched counterparts with normal aging. The relevance of the genetic background and classical intrinsic factors (AD genotype and sex) were determined using a retrospective analysis of population data and an experimental design. Age/stage of disease was considered a source of stochastic and non-stochastic factors. Data from two different colonies of 3xTg-AD mice with distinct genetic backgrounds were analyzed to verify the functional interplay between the studied factors. Data from asymptomatic/prodromal to early/advanced stages of the disease were screened. Then, all factors’ relationships were studied in an experimental design using the same set of animals. The population data unveiled that the genetic background and sex effects were confirmed with regards to the variable body weight, with changes during disease development and progress. Sexual dimorphism was found as an important factor in glucose metabolism. Statistically significant differences in glucose tolerance and behavioral assessment (exploration, anxiety, and cognition in a two-days open-field paradigm) were found when all the factors were analyzed. In summary, the present study shows that all the studied factors should always be considered when assessing the outcome of the research interventions in the field because they have a distinct functional interplay through the process of normal and AD-pathological aging and from a gendered perspective.https://www.mdpi.com/2673-9976/19/1/10obesityglucose metabolismliverdementiaAlzheimer’s diseaseaging |
| spellingShingle | Clara Pérez-Gozalbo Lydia Giménez-Llort Obesity, Impaired Glucose Metabolism and Hepatic Histopathological Damage in 3xTg-AD Mice at Different Stages of Disease Compared to Mice with Normal Aging Biology and Life Sciences Forum obesity glucose metabolism liver dementia Alzheimer’s disease aging |
| title | Obesity, Impaired Glucose Metabolism and Hepatic Histopathological Damage in 3xTg-AD Mice at Different Stages of Disease Compared to Mice with Normal Aging |
| title_full | Obesity, Impaired Glucose Metabolism and Hepatic Histopathological Damage in 3xTg-AD Mice at Different Stages of Disease Compared to Mice with Normal Aging |
| title_fullStr | Obesity, Impaired Glucose Metabolism and Hepatic Histopathological Damage in 3xTg-AD Mice at Different Stages of Disease Compared to Mice with Normal Aging |
| title_full_unstemmed | Obesity, Impaired Glucose Metabolism and Hepatic Histopathological Damage in 3xTg-AD Mice at Different Stages of Disease Compared to Mice with Normal Aging |
| title_short | Obesity, Impaired Glucose Metabolism and Hepatic Histopathological Damage in 3xTg-AD Mice at Different Stages of Disease Compared to Mice with Normal Aging |
| title_sort | obesity impaired glucose metabolism and hepatic histopathological damage in 3xtg ad mice at different stages of disease compared to mice with normal aging |
| topic | obesity glucose metabolism liver dementia Alzheimer’s disease aging |
| url | https://www.mdpi.com/2673-9976/19/1/10 |
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