Quantification of DNA Damage in Heart Tissue as a Novel Prediction Tool for Therapeutic Prognosis of Patients With Dilated Cardiomyopathy

Quantification of DNA Damage in Heart Tissue as a Novel Prediction Tool for Therapeutic Prognosis of Patients With Dilated Cardiomyopathy

Summary: This study evaluated myocardial nuclear staining for the DNA damage markers poly(ADP-ribose) (PAR) and γ-H2A.X in 58 patients with dilated cardiomyopathy. Patients with left ventricular reverse remodeling (LVRR) showed a significantly smaller proportion of PAR-positive nuclei and γ-H2A.X–po...

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Main Authors: Toshiyuki Ko, MD, PhD, Kanna Fujita, MD, Seitaro Nomura, MD, PhD, Yukari Uemura, PhD, Shintaro Yamada, MD, Takashige Tobita, MD, Manami Katoh, MD, PhD, Masahiro Satoh, MD, PhD, Masamichi Ito, MD, PhD, Yukako Domoto, MD, PhD, Yumiko Hosoya, MD, PhD, Eisuke Amiya, MD, PhD, Masaru Hatano, MD, PhD, Hiroyuki Morita, MD, PhD, Masashi Fukayama, MD, PhD, Hiroyuki Aburatani, MD, PhD, Issei Komuro, MD, PhD
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:JACC: Basic to Translational Science
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X19301792

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