REBAMIPIDE: EFFECTIVE DRUG PREVENTION OF NSAID ENTEROPATHY IS POSSIBLE
Prevention of gastrointestinal tract (GIT) complications is the most important element for the rational use of nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin (LDA). Proton pump inhibitors (PPIs) have long been the only medication to prevent these complications. However, PPIs are...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
IMA-PRESS LLC
2016-12-01
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| Series: | Современная ревматология |
| Subjects: | |
| Online Access: | https://mrj.ima-press.net/mrj/article/view/726 |
| _version_ | 1797876728271470592 |
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| author | E. V. Moroz A. E. Karateev |
| author_facet | E. V. Moroz A. E. Karateev |
| author_sort | E. V. Moroz |
| collection | DOAJ |
| description | Prevention of gastrointestinal tract (GIT) complications is the most important element for the rational use of nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin (LDA). Proton pump inhibitors (PPIs) have long been the only medication to prevent these complications. However, PPIs are only effective in preventing and treating upper GIT diseases (NSAID gastropathy) rather than small intestinal injury (NSAID enteropathy). Rebamipide has emerged as a novel agent to protect the gastrointestinal mucosa today. The effect of the drug differs from that of PPIs: it is a typical gastroand enteroprotector that enhances the synthesis of endogenous prostaglandins and possesses a significant anti-inflammatory potential. Rebamipide has long been widely used by doctors inJapan,South Korea, andChinaas an effective and safe agent for the treatment of many diseases of the digestive system. There is a strong evidence base for the efficacy of rebamipide in preventing and treating NSAID gastropathy and NSAID enteropathy (including LDA-induced injuries). Controlled studies have found that the drug is not inferior to the classic gastroprotective agent misoprostol, significantly outperforming the latter in its tolerability. This review describes the mechanism of action of rebamipide and main clinical trials of its therapeutic effect in NSAID gastropathy and NSAID enteropathy. |
| first_indexed | 2024-04-10T02:07:08Z |
| format | Article |
| id | doaj.art-1cea8077e0c646a1b2d60409a13098a4 |
| institution | Directory Open Access Journal |
| issn | 1996-7012 2310-158X |
| language | Russian |
| last_indexed | 2024-04-10T02:07:08Z |
| publishDate | 2016-12-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj.art-1cea8077e0c646a1b2d60409a13098a42023-03-13T08:39:25ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2016-12-011049710510.14412/1996-7012-2016-4-97-1052011REBAMIPIDE: EFFECTIVE DRUG PREVENTION OF NSAID ENTEROPATHY IS POSSIBLEE. V. Moroz0A. E. Karateev1Главный военный клинический госпиталь имени акад. Н.Н. БурденкоНаучно-исследовательский институт ревматологии им. В.А. НасоновойPrevention of gastrointestinal tract (GIT) complications is the most important element for the rational use of nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin (LDA). Proton pump inhibitors (PPIs) have long been the only medication to prevent these complications. However, PPIs are only effective in preventing and treating upper GIT diseases (NSAID gastropathy) rather than small intestinal injury (NSAID enteropathy). Rebamipide has emerged as a novel agent to protect the gastrointestinal mucosa today. The effect of the drug differs from that of PPIs: it is a typical gastroand enteroprotector that enhances the synthesis of endogenous prostaglandins and possesses a significant anti-inflammatory potential. Rebamipide has long been widely used by doctors inJapan,South Korea, andChinaas an effective and safe agent for the treatment of many diseases of the digestive system. There is a strong evidence base for the efficacy of rebamipide in preventing and treating NSAID gastropathy and NSAID enteropathy (including LDA-induced injuries). Controlled studies have found that the drug is not inferior to the classic gastroprotective agent misoprostol, significantly outperforming the latter in its tolerability. This review describes the mechanism of action of rebamipide and main clinical trials of its therapeutic effect in NSAID gastropathy and NSAID enteropathy.https://mrj.ima-press.net/mrj/article/view/726нестероидные противовоспалительные препаратынизкие дозы аспиринанпвп-гастропатиянпвп-энтеропатияингибиторы протонной помпымизопростолребамипид |
| spellingShingle | E. V. Moroz A. E. Karateev REBAMIPIDE: EFFECTIVE DRUG PREVENTION OF NSAID ENTEROPATHY IS POSSIBLE Современная ревматология нестероидные противовоспалительные препараты низкие дозы аспирина нпвп-гастропатия нпвп-энтеропатия ингибиторы протонной помпы мизопростол ребамипид |
| title | REBAMIPIDE: EFFECTIVE DRUG PREVENTION OF NSAID ENTEROPATHY IS POSSIBLE |
| title_full | REBAMIPIDE: EFFECTIVE DRUG PREVENTION OF NSAID ENTEROPATHY IS POSSIBLE |
| title_fullStr | REBAMIPIDE: EFFECTIVE DRUG PREVENTION OF NSAID ENTEROPATHY IS POSSIBLE |
| title_full_unstemmed | REBAMIPIDE: EFFECTIVE DRUG PREVENTION OF NSAID ENTEROPATHY IS POSSIBLE |
| title_short | REBAMIPIDE: EFFECTIVE DRUG PREVENTION OF NSAID ENTEROPATHY IS POSSIBLE |
| title_sort | rebamipide effective drug prevention of nsaid enteropathy is possible |
| topic | нестероидные противовоспалительные препараты низкие дозы аспирина нпвп-гастропатия нпвп-энтеропатия ингибиторы протонной помпы мизопростол ребамипид |
| url | https://mrj.ima-press.net/mrj/article/view/726 |
| work_keys_str_mv | AT evmoroz rebamipideeffectivedrugpreventionofnsaidenteropathyispossible AT aekarateev rebamipideeffectivedrugpreventionofnsaidenteropathyispossible |