Larvicidal Activity of Cinnamic Acid Derivatives: Investigating Alternative Products for <i>Aedes aegypti</i> L. Control
The mosquito <i>Aedes aegypti</i> transmits the virus that causes dengue, yellow fever, Zika and Chikungunya viruses, and in several regions of the planet represents a vector of great clinical importance. In terms of mortality and morbidity, infections caused by <i>Ae. aegypti</...
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| Format: | Article |
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MDPI AG
2020-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/1/61 |
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| author | Marianna O. Araújo Yunierkis Pérez-Castillo Louise H. G. Oliveira Fabíola C. Nunes Damião P. de Sousa |
| author_facet | Marianna O. Araújo Yunierkis Pérez-Castillo Louise H. G. Oliveira Fabíola C. Nunes Damião P. de Sousa |
| author_sort | Marianna O. Araújo |
| collection | DOAJ |
| description | The mosquito <i>Aedes aegypti</i> transmits the virus that causes dengue, yellow fever, Zika and Chikungunya viruses, and in several regions of the planet represents a vector of great clinical importance. In terms of mortality and morbidity, infections caused by <i>Ae. aegypti</i> are among the most serious arthropod transmitted viral diseases. The present study investigated the larvicidal potential of seventeen cinnamic acid derivatives against fourth stage <i>Ae. aegypti</i> larvae. The larvicide assays were performed using larval mortality rates to determine lethal concentration (LC<sub>50</sub>). Compounds containing the medium alkyl chains butyl cinnamate (<b>7</b>) and pentyl cinnamate (<b>8</b>) presented excellent larvicidal activity with LC<sub>50</sub> values of around 0.21–0.17 mM, respectively. While among the derivatives with aryl substituents, the best LC<sub>50</sub> result was 0.55 mM for benzyl cinnamate (<b>13</b>). The tested derivatives were natural compounds and in pharmacology and antiparasitic studies, many have been evaluated using biological models for environmental and toxicological safety. Molecular modeling analyses suggest that the larvicidal activity of these compounds might be due to a multi-target mechanism of action involving inhibition of a carbonic anhydrase (CA), a histone deacetylase (HDAC2), and two sodium-dependent cation-chloride co-transporters (CCC2 e CCC3). |
| first_indexed | 2024-03-10T13:47:09Z |
| format | Article |
| id | doaj.art-1ceb3b26e4fb4a759ea9dfe20b473230 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T13:47:09Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1ceb3b26e4fb4a759ea9dfe20b4732302023-11-21T02:30:45ZengMDPI AGMolecules1420-30492020-12-012616110.3390/molecules26010061Larvicidal Activity of Cinnamic Acid Derivatives: Investigating Alternative Products for <i>Aedes aegypti</i> L. ControlMarianna O. Araújo0Yunierkis Pérez-Castillo1Louise H. G. Oliveira2Fabíola C. Nunes3Damião P. de Sousa4Post Graduation Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58051-900, BrazilBio-Cheminformatics Research Group and Escuela de Ciencias Físicas y Matemáticas, Universidad de Las Américas, Quito 170125, EcuadorBiotechnology Center, Federal University of Paraíba, João Pessoa 58051-900, BrazilBiotechnology Center, Federal University of Paraíba, João Pessoa 58051-900, BrazilPost Graduation Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58051-900, BrazilThe mosquito <i>Aedes aegypti</i> transmits the virus that causes dengue, yellow fever, Zika and Chikungunya viruses, and in several regions of the planet represents a vector of great clinical importance. In terms of mortality and morbidity, infections caused by <i>Ae. aegypti</i> are among the most serious arthropod transmitted viral diseases. The present study investigated the larvicidal potential of seventeen cinnamic acid derivatives against fourth stage <i>Ae. aegypti</i> larvae. The larvicide assays were performed using larval mortality rates to determine lethal concentration (LC<sub>50</sub>). Compounds containing the medium alkyl chains butyl cinnamate (<b>7</b>) and pentyl cinnamate (<b>8</b>) presented excellent larvicidal activity with LC<sub>50</sub> values of around 0.21–0.17 mM, respectively. While among the derivatives with aryl substituents, the best LC<sub>50</sub> result was 0.55 mM for benzyl cinnamate (<b>13</b>). The tested derivatives were natural compounds and in pharmacology and antiparasitic studies, many have been evaluated using biological models for environmental and toxicological safety. Molecular modeling analyses suggest that the larvicidal activity of these compounds might be due to a multi-target mechanism of action involving inhibition of a carbonic anhydrase (CA), a histone deacetylase (HDAC2), and two sodium-dependent cation-chloride co-transporters (CCC2 e CCC3).https://www.mdpi.com/1420-3049/26/1/61natural productsmedicinal plantsmosquitoescinnamic esterdengueyellow fever |
| spellingShingle | Marianna O. Araújo Yunierkis Pérez-Castillo Louise H. G. Oliveira Fabíola C. Nunes Damião P. de Sousa Larvicidal Activity of Cinnamic Acid Derivatives: Investigating Alternative Products for <i>Aedes aegypti</i> L. Control Molecules natural products medicinal plants mosquitoes cinnamic ester dengue yellow fever |
| title | Larvicidal Activity of Cinnamic Acid Derivatives: Investigating Alternative Products for <i>Aedes aegypti</i> L. Control |
| title_full | Larvicidal Activity of Cinnamic Acid Derivatives: Investigating Alternative Products for <i>Aedes aegypti</i> L. Control |
| title_fullStr | Larvicidal Activity of Cinnamic Acid Derivatives: Investigating Alternative Products for <i>Aedes aegypti</i> L. Control |
| title_full_unstemmed | Larvicidal Activity of Cinnamic Acid Derivatives: Investigating Alternative Products for <i>Aedes aegypti</i> L. Control |
| title_short | Larvicidal Activity of Cinnamic Acid Derivatives: Investigating Alternative Products for <i>Aedes aegypti</i> L. Control |
| title_sort | larvicidal activity of cinnamic acid derivatives investigating alternative products for i aedes aegypti i l control |
| topic | natural products medicinal plants mosquitoes cinnamic ester dengue yellow fever |
| url | https://www.mdpi.com/1420-3049/26/1/61 |
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