Oral microbiome and obesity in a large study of low-income and African-American populations
Few studies have evaluated the relationship of oral microbiome with obesity. We investigated the oral microbiome among 647 obese and 969 non-obese individuals from the Southern Community Cohort Study, through 16S rRNA gene sequencing in mouth rinse samples. We first investigated 16 taxa in two probi...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Journal of Oral Microbiology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/20002297.2019.1650597 |
| _version_ | 1818855446530752512 |
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| author | Yaohua Yang Qiuyin Cai Wei Zheng Mark Steinwandel William J. Blot Xiao-Ou Shu Jirong Long |
| author_facet | Yaohua Yang Qiuyin Cai Wei Zheng Mark Steinwandel William J. Blot Xiao-Ou Shu Jirong Long |
| author_sort | Yaohua Yang |
| collection | DOAJ |
| description | Few studies have evaluated the relationship of oral microbiome with obesity. We investigated the oral microbiome among 647 obese and 969 non-obese individuals from the Southern Community Cohort Study, through 16S rRNA gene sequencing in mouth rinse samples. We first investigated 16 taxa in two probiotic genera, Bifidobacterium and Lactobacillus. Among them, eight showed nominal associations with obesity (P < 0.05). Especially, Bifidobacterium (odds ratio [OR] = 0.67, 95% confidence interval [CI]:0.54, 0.83) and Bifidobacterium longum (OR = 0.57, 95% CI: 0.45, 0.73) were significantly associated with decreased obesity prevalence with false-discovery rate (FDR)-corrected P of 0.01 and 5.41 × 10−4, respectively. Multiple other bacterial taxa were also significantly associated with obesity prevalence at FDR-corrected P < 0.05. Among them, five in Firmicutes and two respectively in Actinobacteria and Proteobacteria were significantly associated with increased obesity prevalence. Significant associations with decreased obesity prevalence were observed for two taxa respectively in Actinobacteria and Firmicutes. Most of these taxa were associated with body mass index at study enrollment and weight gain during adulthood. Also, most of these associations were observed in both European- and African-Americans. Our findings indicate that multiple oral bacterial taxa, including several probiotic taxa, were significantly associated with obesity. |
| first_indexed | 2024-12-19T08:08:44Z |
| format | Article |
| id | doaj.art-1ceb5429556944f58917a27c2f434eff |
| institution | Directory Open Access Journal |
| issn | 2000-2297 |
| language | English |
| last_indexed | 2024-12-19T08:08:44Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Oral Microbiology |
| spelling | doaj.art-1ceb5429556944f58917a27c2f434eff2022-12-21T20:29:41ZengTaylor & Francis GroupJournal of Oral Microbiology2000-22972019-01-0111110.1080/20002297.2019.16505971650597Oral microbiome and obesity in a large study of low-income and African-American populationsYaohua Yang0Qiuyin Cai1Wei Zheng2Mark Steinwandel3William J. Blot4Xiao-Ou Shu5Jirong Long6Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical CenterVanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical CenterVanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical CenterVanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical CenterVanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical CenterVanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical CenterVanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical CenterFew studies have evaluated the relationship of oral microbiome with obesity. We investigated the oral microbiome among 647 obese and 969 non-obese individuals from the Southern Community Cohort Study, through 16S rRNA gene sequencing in mouth rinse samples. We first investigated 16 taxa in two probiotic genera, Bifidobacterium and Lactobacillus. Among them, eight showed nominal associations with obesity (P < 0.05). Especially, Bifidobacterium (odds ratio [OR] = 0.67, 95% confidence interval [CI]:0.54, 0.83) and Bifidobacterium longum (OR = 0.57, 95% CI: 0.45, 0.73) were significantly associated with decreased obesity prevalence with false-discovery rate (FDR)-corrected P of 0.01 and 5.41 × 10−4, respectively. Multiple other bacterial taxa were also significantly associated with obesity prevalence at FDR-corrected P < 0.05. Among them, five in Firmicutes and two respectively in Actinobacteria and Proteobacteria were significantly associated with increased obesity prevalence. Significant associations with decreased obesity prevalence were observed for two taxa respectively in Actinobacteria and Firmicutes. Most of these taxa were associated with body mass index at study enrollment and weight gain during adulthood. Also, most of these associations were observed in both European- and African-Americans. Our findings indicate that multiple oral bacterial taxa, including several probiotic taxa, were significantly associated with obesity.http://dx.doi.org/10.1080/20002297.2019.1650597oral microbiomeobesity16s rrna gene sequencing; southern community cohort study; probiotic taxa |
| spellingShingle | Yaohua Yang Qiuyin Cai Wei Zheng Mark Steinwandel William J. Blot Xiao-Ou Shu Jirong Long Oral microbiome and obesity in a large study of low-income and African-American populations Journal of Oral Microbiology oral microbiome obesity 16s rrna gene sequencing; southern community cohort study; probiotic taxa |
| title | Oral microbiome and obesity in a large study of low-income and African-American populations |
| title_full | Oral microbiome and obesity in a large study of low-income and African-American populations |
| title_fullStr | Oral microbiome and obesity in a large study of low-income and African-American populations |
| title_full_unstemmed | Oral microbiome and obesity in a large study of low-income and African-American populations |
| title_short | Oral microbiome and obesity in a large study of low-income and African-American populations |
| title_sort | oral microbiome and obesity in a large study of low income and african american populations |
| topic | oral microbiome obesity 16s rrna gene sequencing; southern community cohort study; probiotic taxa |
| url | http://dx.doi.org/10.1080/20002297.2019.1650597 |
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