Cell-specific imputation of drug connectivity mapping with incomplete data

Cell-specific imputation of drug connectivity mapping with incomplete data

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Drug repositioning allows expedited discovery of new applications for existing compounds, but re-screening vast compound libraries is often prohibitively expensive. “Connectivity mapping” is a process that links drugs to diseases by identifying compounds whose impact on expression in a collection of...

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Bibliographic Details
Main Authors: Diana Sapashnik, Rebecca Newman, Christopher Michael Pietras, Di Zhou, Kapil Devkota, Fangfang Qu, Lior Kofman, Sean Boudreau, Inbar Fried, Donna K. Slonim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934325/?tool=EBI

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