Systematic screening reveals synergistic interactions that overcome MAPK inhibitor resistance in cancer cells

Systematic screening reveals synergistic interactions that overcome MAPK inhibitor resistance in cancer cells

Objective: Effective adjuvant therapeutic strategies are urgently needed to overcome MAPK inhibitor (MAPKi) resistance, which is one of the most common forms of resistance that has emerged in many types of cancers. Here, we aimed to systematically identify the genetic interactions underlying MAPKi r...

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Bibliographic Details
Main Authors:	Yu Yu, Minzhen Tao, Libin Xu, Lei Cao, Baoyu Le, Na An, Jilin Dong, Yajie Xu, Baoxing Yang, Wei Li, Bing Liu, Qiong Wu, Yinying Lu, Zhen Xie, Xiaohua Lian
Format:	Article
Language:	English
Published:	China Anti-Cancer Association 2022-02-01
Series:	Cancer Biology & Medicine
Subjects:	pair-wise sgrna library genetic interactions mapki resistance combinatorial therapy cancer stemness
Online Access:	http://www.cancerbiomed.org/index.php/cocr/article/view/1863

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