Ziprasidone, a second-generation antipsychotic, affects core clock gene mRNA expression in mice
Some psychiatric diseases are associated with disruptions in the circadian clock system. Ziprasidone (ZIP), a second-generation antipsychotic, is widely used for psychiatry-related pharmacotherapy but its mechanism has not been clearly elucidated. We measured clock gene fluctuation patterns in the h...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-09-01
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| Series: | Journal of Pharmacological Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861320300621 |
| _version_ | 1828847915879104512 |
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| author | Shunpei Moriya Hitoshi Takahashi Daiki Masukawa Makiko Yamada Jun Ishigooka Katsuji Nishimura |
| author_facet | Shunpei Moriya Hitoshi Takahashi Daiki Masukawa Makiko Yamada Jun Ishigooka Katsuji Nishimura |
| author_sort | Shunpei Moriya |
| collection | DOAJ |
| description | Some psychiatric diseases are associated with disruptions in the circadian clock system. Ziprasidone (ZIP), a second-generation antipsychotic, is widely used for psychiatry-related pharmacotherapy but its mechanism has not been clearly elucidated. We measured clock gene fluctuation patterns in the hippocampus and the amygdala in ZIP-treated mice. ZIP significantly increased Per1, Per2, and Bmal1 mRNA 2 h after the lights were turned off (ZT14) in the hippocampus, but not in the amygdala. These results suggest that ZIP might affect clock gene regulation, which could represent the pathway underlying symptom amelioration. |
| first_indexed | 2024-12-12T22:19:46Z |
| format | Article |
| id | doaj.art-1cefc9863f0642c5a85c2f8f24146284 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-12T22:19:46Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-1cefc9863f0642c5a85c2f8f241462842022-12-22T00:09:58ZengElsevierJournal of Pharmacological Sciences1347-86132020-09-0114415759Ziprasidone, a second-generation antipsychotic, affects core clock gene mRNA expression in miceShunpei Moriya0Hitoshi Takahashi1Daiki Masukawa2Makiko Yamada3Jun Ishigooka4Katsuji Nishimura5Department of Psychiatry, Tokyo Women's Medical University, School of Medicine, Shinjuku-ku, Tokyo, 162-8666, Japan; Department of Physiology, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima, 890-8544, Japan; Corresponding author. Department of Psychiatry, Tokyo Women's Medical University, School of Medicine, Shinjuku-ku, Tokyo, 162-8666, Japan. Fax: +81 3 3351 8979.Department of Psychiatry, Tokyo Women's Medical University, School of Medicine, Shinjuku-ku, Tokyo, 162-8666, JapanDepartment of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, JapanDepartment of Psychiatry, Tokyo Women's Medical University, School of Medicine, Shinjuku-ku, Tokyo, 162-8666, JapanDepartment of Psychiatry, Tokyo Women's Medical University, School of Medicine, Shinjuku-ku, Tokyo, 162-8666, Japan; CNS Pharmacological Research Institute, Shibuya-ku, Tokyo, 151-0051, JapanDepartment of Psychiatry, Tokyo Women's Medical University, School of Medicine, Shinjuku-ku, Tokyo, 162-8666, JapanSome psychiatric diseases are associated with disruptions in the circadian clock system. Ziprasidone (ZIP), a second-generation antipsychotic, is widely used for psychiatry-related pharmacotherapy but its mechanism has not been clearly elucidated. We measured clock gene fluctuation patterns in the hippocampus and the amygdala in ZIP-treated mice. ZIP significantly increased Per1, Per2, and Bmal1 mRNA 2 h after the lights were turned off (ZT14) in the hippocampus, but not in the amygdala. These results suggest that ZIP might affect clock gene regulation, which could represent the pathway underlying symptom amelioration.http://www.sciencedirect.com/science/article/pii/S1347861320300621ZiprasidoneClock geneHippocampus |
| spellingShingle | Shunpei Moriya Hitoshi Takahashi Daiki Masukawa Makiko Yamada Jun Ishigooka Katsuji Nishimura Ziprasidone, a second-generation antipsychotic, affects core clock gene mRNA expression in mice Journal of Pharmacological Sciences Ziprasidone Clock gene Hippocampus |
| title | Ziprasidone, a second-generation antipsychotic, affects core clock gene mRNA expression in mice |
| title_full | Ziprasidone, a second-generation antipsychotic, affects core clock gene mRNA expression in mice |
| title_fullStr | Ziprasidone, a second-generation antipsychotic, affects core clock gene mRNA expression in mice |
| title_full_unstemmed | Ziprasidone, a second-generation antipsychotic, affects core clock gene mRNA expression in mice |
| title_short | Ziprasidone, a second-generation antipsychotic, affects core clock gene mRNA expression in mice |
| title_sort | ziprasidone a second generation antipsychotic affects core clock gene mrna expression in mice |
| topic | Ziprasidone Clock gene Hippocampus |
| url | http://www.sciencedirect.com/science/article/pii/S1347861320300621 |
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