Doxazosin stimulates galectin-3 expression and collagen synthesis in HL-1 cardiomyocytes independent of protein kinase C pathway

Doxazosin stimulates galectin-3 expression and collagen synthesis in HL-1 cardiomyocytes independent of protein kinase C pathway

Doxazosin, a drug commonly prescribed for hypertension and prostate disease, increases heart failure risk. However, the underlying mechanism remains unclear. Galectin-3 is an important mediator that plays a pathogenic role in cardiac hypertrophy and heart failure. In the present study, we investigat...

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Bibliographic Details
Main Authors: Xiaoqian Qian, Mingyang Li, Mary B Wagner, Guangping Chen, Xiang Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Pharmacology
Subjects:
Collagen
Protein Kinase C
cardiac fibrosis
adrenergic receptor
cardiomycyte
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00495/full

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