Evaluation of mammographic surveillance services in women aged 40–49 years with a moderate family history of breast cancer: a single-arm cohort study
Background: Women with a significant family history of breast cancer are often offered more intensive and earlier surveillance than is offered to the general population in the National Breast Screening Programme. Up to now, this strategy has not been fully evaluated. Objective: To evaluate the benef...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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NIHR Journals Library
2013-03-01
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| Series: | Health Technology Assessment |
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| Online Access: | https://doi.org/10.3310/hta17110 |
| _version_ | 1817989980723609600 |
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| author | SW Duffy J Mackay S Thomas E Anderson THH Chen I Ellis G Evans H Fielder R Fox G Gui D Macmillan S Moss C Rogers M Sibbering M Wallis R Warren E Watson D Whynes P Allgood J Caunt |
| author_facet | SW Duffy J Mackay S Thomas E Anderson THH Chen I Ellis G Evans H Fielder R Fox G Gui D Macmillan S Moss C Rogers M Sibbering M Wallis R Warren E Watson D Whynes P Allgood J Caunt |
| author_sort | SW Duffy |
| collection | DOAJ |
| description | Background: Women with a significant family history of breast cancer are often offered more intensive and earlier surveillance than is offered to the general population in the National Breast Screening Programme. Up to now, this strategy has not been fully evaluated. Objective: To evaluate the benefit of mammographic surveillance for women aged 40–49 years at moderate risk of breast cancer due to family history. The study is referred to as FH01. Design: This was a single-arm cohort study with recruitment taking place between January 2003 and February 2007. Recruits were women aged < 50 years with a family history of breast or ovarian cancer conferring at least a 3% risk of breast cancer between ages 40 and 49 years. The women were offered annual mammography for at least 5 years and observed for the occurrence of breast cancer during the surveillance period. The age group 40–44 years was targeted so that they would still be aged < 50 years after 5 years of surveillance. Setting: Seventy-four surveillance centres in England, Wales, Scotland and Northern Ireland. Participants: A total of 6710 women, 94% of whom were aged < 45 years at recruitment, with a family history of breast cancer estimated to imply at least a 3% risk of the disease between the ages of 40 and 50 years. Interventions: Annual mammography for at least 5 years. Main outcome measures: The primary study end point was the predicted risk of death from breast cancer as estimated from the size, lymph node status and grade of the tumours diagnosed. This was compared with the control group from the UK Breast Screening Age Trial (Age Trial), adjusting for the different underlying incidence in the two populations. Results: As of December 2010, there were 165 breast cancers diagnosed in 37,025 person-years of observation and 30,556 mammographic screening episodes. Of these, 122 (74%) were diagnosed at screening. The cancers included 44 (27%) cases of ductal carcinoma in situ. There were 19 predicted deaths in 37,025 person-years in FH01, with an estimated incidence of 6.3 per 1000 per year. The corresponding figures for the Age Trial control group were 204 predicted deaths in 622,127 person-years and an incidence of 2.4 per 1000 per year. This gave an estimated 40% reduction in breast cancer mortality (relative risk = 0.60; 95% confidence interval 0.37 to 0.98; p = 0.04). Conclusions: Annual mammography in women aged 40–49 years with a significant family history of breast or ovarian cancer is both clinically effective in reducing breast cancer mortality and cost-effective. There is a need to further standardise familial risk assessment, to research the impact of digital mammography and to clarify the role of breast density in this population. Trial registration: National Research Register N0484114809. Funding: This project was funded by the NIHR Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 17, No. 11. See the HTA programme website for further project information. |
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| language | English |
| last_indexed | 2024-04-14T00:53:19Z |
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| spelling | doaj.art-1cf020094d47453aa7775dc686b216f62022-12-22T02:21:42ZengNIHR Journals LibraryHealth Technology Assessment1366-52782046-49242013-03-01171110.3310/hta1711001/18/01Evaluation of mammographic surveillance services in women aged 40–49 years with a moderate family history of breast cancer: a single-arm cohort studySW Duffy0J Mackay1S Thomas2E Anderson3THH Chen4I Ellis5G Evans6H Fielder7R Fox8G Gui9D Macmillan10S Moss11C Rogers12M Sibbering13M Wallis14R Warren15E Watson16D Whynes17P Allgood18J Caunt19Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UKDepartment of Biology, University College, London, UKPublic Health Wales, Cardiff, Wales, UKEdinburgh Breast Unit, Western General Hospital, Edinburgh, UKDivision of Biostatistics, National Taiwan University, Taipei, ChinaDepartment of Histopathology, University of Nottingham, Nottingham, UKGenetic Medicine, University of Manchester, Manchester, UKPublic Health Wales, Cardiff, Wales, UKPublic Health Wales, Cardiff, Wales, UKBreast Unit, Royal Marsden Hospital, London, UKBreast Unit, Nottingham City Hospital, Nottingham, UKCentre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UKPublic Health Wales, Cardiff, Wales, UKGeneral Surgery, Royal Derby Hospital, Derby, UKDepartment of Radiology, Addenbrooke's Hospital, Cambridge, UKDepartment of Radiology, Addenbrooke's Hospital, Cambridge, UKDepartment of Clinical Health Care, Oxford Brookes University, Oxford, UKDepartment of Histopathology, University of Nottingham, Nottingham, UKCentre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UKBreast Test Wales, Cardiff, Wales, UKBackground: Women with a significant family history of breast cancer are often offered more intensive and earlier surveillance than is offered to the general population in the National Breast Screening Programme. Up to now, this strategy has not been fully evaluated. Objective: To evaluate the benefit of mammographic surveillance for women aged 40–49 years at moderate risk of breast cancer due to family history. The study is referred to as FH01. Design: This was a single-arm cohort study with recruitment taking place between January 2003 and February 2007. Recruits were women aged < 50 years with a family history of breast or ovarian cancer conferring at least a 3% risk of breast cancer between ages 40 and 49 years. The women were offered annual mammography for at least 5 years and observed for the occurrence of breast cancer during the surveillance period. The age group 40–44 years was targeted so that they would still be aged < 50 years after 5 years of surveillance. Setting: Seventy-four surveillance centres in England, Wales, Scotland and Northern Ireland. Participants: A total of 6710 women, 94% of whom were aged < 45 years at recruitment, with a family history of breast cancer estimated to imply at least a 3% risk of the disease between the ages of 40 and 50 years. Interventions: Annual mammography for at least 5 years. Main outcome measures: The primary study end point was the predicted risk of death from breast cancer as estimated from the size, lymph node status and grade of the tumours diagnosed. This was compared with the control group from the UK Breast Screening Age Trial (Age Trial), adjusting for the different underlying incidence in the two populations. Results: As of December 2010, there were 165 breast cancers diagnosed in 37,025 person-years of observation and 30,556 mammographic screening episodes. Of these, 122 (74%) were diagnosed at screening. The cancers included 44 (27%) cases of ductal carcinoma in situ. There were 19 predicted deaths in 37,025 person-years in FH01, with an estimated incidence of 6.3 per 1000 per year. The corresponding figures for the Age Trial control group were 204 predicted deaths in 622,127 person-years and an incidence of 2.4 per 1000 per year. This gave an estimated 40% reduction in breast cancer mortality (relative risk = 0.60; 95% confidence interval 0.37 to 0.98; p = 0.04). Conclusions: Annual mammography in women aged 40–49 years with a significant family history of breast or ovarian cancer is both clinically effective in reducing breast cancer mortality and cost-effective. There is a need to further standardise familial risk assessment, to research the impact of digital mammography and to clarify the role of breast density in this population. Trial registration: National Research Register N0484114809. Funding: This project was funded by the NIHR Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 17, No. 11. See the HTA programme website for further project information.https://doi.org/10.3310/hta17110cohort studyclinical effectivenesscost-effectivenessmammographybreast cancerfamily history |
| spellingShingle | SW Duffy J Mackay S Thomas E Anderson THH Chen I Ellis G Evans H Fielder R Fox G Gui D Macmillan S Moss C Rogers M Sibbering M Wallis R Warren E Watson D Whynes P Allgood J Caunt Evaluation of mammographic surveillance services in women aged 40–49 years with a moderate family history of breast cancer: a single-arm cohort study Health Technology Assessment cohort study clinical effectiveness cost-effectiveness mammography breast cancer family history |
| title | Evaluation of mammographic surveillance services in women aged 40–49 years with a moderate family history of breast cancer: a single-arm cohort study |
| title_full | Evaluation of mammographic surveillance services in women aged 40–49 years with a moderate family history of breast cancer: a single-arm cohort study |
| title_fullStr | Evaluation of mammographic surveillance services in women aged 40–49 years with a moderate family history of breast cancer: a single-arm cohort study |
| title_full_unstemmed | Evaluation of mammographic surveillance services in women aged 40–49 years with a moderate family history of breast cancer: a single-arm cohort study |
| title_short | Evaluation of mammographic surveillance services in women aged 40–49 years with a moderate family history of breast cancer: a single-arm cohort study |
| title_sort | evaluation of mammographic surveillance services in women aged 40 49 years with a moderate family history of breast cancer a single arm cohort study |
| topic | cohort study clinical effectiveness cost-effectiveness mammography breast cancer family history |
| url | https://doi.org/10.3310/hta17110 |
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