Health-Related Quality of Life 10 Years after Liver Transplantation: A Longitudinal Retrospective Review
As survival post-liver transplantation (LTx) improves, it becomes increasingly important to understand how long-term health-related quality of life (HRQOL) is impacted. This was a longitudinal review examining HRQOL measured by Pediatric Liver Transplant Quality of Life (PeLTQL) in children between...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/1/111 |
| _version_ | 1797412549070684160 |
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| author | Amber Hager Diana Mager Cheri Robert David Nicholas Susan Gilmour |
| author_facet | Amber Hager Diana Mager Cheri Robert David Nicholas Susan Gilmour |
| author_sort | Amber Hager |
| collection | DOAJ |
| description | As survival post-liver transplantation (LTx) improves, it becomes increasingly important to understand how long-term health-related quality of life (HRQOL) is impacted. This was a longitudinal review examining HRQOL measured by Pediatric Liver Transplant Quality of Life (PeLTQL) in children between 8-17 years who underwent LTx (1.4 [0.8–3.3] years) at least one year prior to assessment. Demographic, medical, anthropometric, and HRQOL data (self-reported and parent proxy) were retrospectively collected over four years (2014–2017) at annual LTx clinic visits. The study included 35 patients (18M, 17F) and their parents/guardians. Parent-proxy and child PeLTQL scores (total, subdomain) showed good to excellent agreement (<i>p</i> > 0.05) and did not change over four years (<i>p</i> > 0.05). Younger age (<12 years) and Caucasian ancestry were associated with higher parental and self-reported perceptions of HRQOL, respectively (future health, coping and adjustment, total scores). Parent perceived lower HRQOL in social–emotional sub-domain (<i>p</i> = 0.03) and the child reported lower sub-domain scores related to coping and adjustment (<i>p</i> = 0.04) when the child was noted to have co-morbid conditions related to mental health and neurocognitive development (25.7%). While child–parent perceptions of HRQOL in a multi-ethnic population of pediatric LTx recipients remain unchanged 10 years post-LTx, adolescents of non-Caucasian ancestry remain a population at risk for lower HRQOL. |
| first_indexed | 2024-03-09T05:04:44Z |
| format | Article |
| id | doaj.art-1cf0b86ff2844d65b8d18f30fe49b4ea |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T05:04:44Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-1cf0b86ff2844d65b8d18f30fe49b4ea2023-12-03T12:55:43ZengMDPI AGDiagnostics2075-44182021-01-0111111110.3390/diagnostics11010111Health-Related Quality of Life 10 Years after Liver Transplantation: A Longitudinal Retrospective ReviewAmber Hager0Diana Mager1Cheri Robert2David Nicholas3Susan Gilmour4Department of Agricultural, Food & Nutritional Sciences, University of Alberta, Edmonton, AB T6G 2E1, CanadaDepartment of Agricultural, Food & Nutritional Sciences, University of Alberta, Edmonton, AB T6G 2E1, CanadaDepartment of Pediatrics, University of Alberta, Edmonton, AB T6G 1C9, CanadaDepartment of Social Work, University of Calgary, Calgary, AB T5J 4P6, CanadaDepartment of Pediatrics, University of Alberta, Edmonton, AB T6G 1C9, CanadaAs survival post-liver transplantation (LTx) improves, it becomes increasingly important to understand how long-term health-related quality of life (HRQOL) is impacted. This was a longitudinal review examining HRQOL measured by Pediatric Liver Transplant Quality of Life (PeLTQL) in children between 8-17 years who underwent LTx (1.4 [0.8–3.3] years) at least one year prior to assessment. Demographic, medical, anthropometric, and HRQOL data (self-reported and parent proxy) were retrospectively collected over four years (2014–2017) at annual LTx clinic visits. The study included 35 patients (18M, 17F) and their parents/guardians. Parent-proxy and child PeLTQL scores (total, subdomain) showed good to excellent agreement (<i>p</i> > 0.05) and did not change over four years (<i>p</i> > 0.05). Younger age (<12 years) and Caucasian ancestry were associated with higher parental and self-reported perceptions of HRQOL, respectively (future health, coping and adjustment, total scores). Parent perceived lower HRQOL in social–emotional sub-domain (<i>p</i> = 0.03) and the child reported lower sub-domain scores related to coping and adjustment (<i>p</i> = 0.04) when the child was noted to have co-morbid conditions related to mental health and neurocognitive development (25.7%). While child–parent perceptions of HRQOL in a multi-ethnic population of pediatric LTx recipients remain unchanged 10 years post-LTx, adolescents of non-Caucasian ancestry remain a population at risk for lower HRQOL.https://www.mdpi.com/2075-4418/11/1/111health-related quality of lifepediatricschildrenliver transplantationliver diseaseliver |
| spellingShingle | Amber Hager Diana Mager Cheri Robert David Nicholas Susan Gilmour Health-Related Quality of Life 10 Years after Liver Transplantation: A Longitudinal Retrospective Review Diagnostics health-related quality of life pediatrics children liver transplantation liver disease liver |
| title | Health-Related Quality of Life 10 Years after Liver Transplantation: A Longitudinal Retrospective Review |
| title_full | Health-Related Quality of Life 10 Years after Liver Transplantation: A Longitudinal Retrospective Review |
| title_fullStr | Health-Related Quality of Life 10 Years after Liver Transplantation: A Longitudinal Retrospective Review |
| title_full_unstemmed | Health-Related Quality of Life 10 Years after Liver Transplantation: A Longitudinal Retrospective Review |
| title_short | Health-Related Quality of Life 10 Years after Liver Transplantation: A Longitudinal Retrospective Review |
| title_sort | health related quality of life 10 years after liver transplantation a longitudinal retrospective review |
| topic | health-related quality of life pediatrics children liver transplantation liver disease liver |
| url | https://www.mdpi.com/2075-4418/11/1/111 |
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