The mammalian peroxisomal membrane is permeable to both GSH and GSSG – Implications for intraperoxisomal redox homeostasis

The mammalian peroxisomal membrane is permeable to both GSH and GSSG – Implications for intraperoxisomal redox homeostasis

Despite the large amounts of H2O2 generated in mammalian peroxisomes, cysteine residues of intraperoxisomal proteins are maintained in a reduced state. The biochemistry behind this phenomenon remains unexplored, and simple questions such as “is the peroxisomal membrane permeable to glutathione?” or...

Full description

Bibliographic Details
Main Authors: Maria J. Ferreira, Tony A. Rodrigues, Ana G. Pedrosa, Luís Gales, Armindo Salvador, Tânia Francisco, Jorge E. Azevedo
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Redox Biology
Subjects:
Peroxisome
Glutathione
Membrane permeability
Glutaredoxin
Protein import
Kinetic simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723001659

Internet

http://www.sciencedirect.com/science/article/pii/S2213231723001659

Similar Items