Engineering customized nanovaccines for enhanced cancer immunotherapy
Nanovaccines have gathered significant attention for their potential to elicit tumor-specific immunological responses. Despite notable progress in tumor immunotherapy, nanovaccines still encounter considerable challenges such as low delivery efficiency, limited targeting ability, and suboptimal effi...
| Asıl Yazarlar: | , , , , , |
|---|---|
| Materyal Türü: | Makale |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
KeAi Communications Co., Ltd.
2024-06-01
|
| Seri Bilgileri: | Bioactive Materials |
| Konular: | |
| Online Erişim: | http://www.sciencedirect.com/science/article/pii/S2452199X24000732 |
| _version_ | 1827149900657197056 |
|---|---|
| author | Jinyu Guo Changhua Liu Zhaoyang Qi Ting Qiu Jin Zhang Huanghao Yang |
| author_facet | Jinyu Guo Changhua Liu Zhaoyang Qi Ting Qiu Jin Zhang Huanghao Yang |
| author_sort | Jinyu Guo |
| collection | DOAJ |
| description | Nanovaccines have gathered significant attention for their potential to elicit tumor-specific immunological responses. Despite notable progress in tumor immunotherapy, nanovaccines still encounter considerable challenges such as low delivery efficiency, limited targeting ability, and suboptimal efficacy. With an aim of addressing these issues, engineering customized nanovaccines through modification or functionalization has emerged as a promising approach. These tailored nanovaccines not only enhance antigen presentation, but also effectively modulate immunosuppression within the tumor microenvironment. Specifically, they are distinguished by their diverse sizes, shapes, charges, structures, and unique physicochemical properties, along with targeting ligands. These features of nanovaccines facilitate lymph node accumulation and activation/regulation of immune cells. This overview of bespoke nanovaccines underscores their potential in both prophylactic and therapeutic applications, offering insights into their future development and role in cancer immunotherapy. |
| first_indexed | 2024-04-25T01:12:14Z |
| format | Article |
| id | doaj.art-1cf329aa0f1d444c994dacb2fc038ced |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2025-03-20T21:25:32Z |
| publishDate | 2024-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-1cf329aa0f1d444c994dacb2fc038ced2024-08-12T04:31:10ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2024-06-0136330357Engineering customized nanovaccines for enhanced cancer immunotherapyJinyu Guo0Changhua Liu1Zhaoyang Qi2Ting Qiu3Jin Zhang4Huanghao Yang5Qingyuan Innovation Laboratory, 1 Xueyuan Road, Quanzhou, 362801, PR China; College of Chemical Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, PR ChinaCollege of Chemical Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, PR ChinaQingyuan Innovation Laboratory, 1 Xueyuan Road, Quanzhou, 362801, PR ChinaQingyuan Innovation Laboratory, 1 Xueyuan Road, Quanzhou, 362801, PR China; College of Chemical Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, PR ChinaQingyuan Innovation Laboratory, 1 Xueyuan Road, Quanzhou, 362801, PR China; College of Chemical Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, PR China; Corresponding author. Qingyuan Innovation Laboratory, 1 Xueyuan Road, Quanzhou, 362801, PR China.MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, PR China; Corresponding author.Nanovaccines have gathered significant attention for their potential to elicit tumor-specific immunological responses. Despite notable progress in tumor immunotherapy, nanovaccines still encounter considerable challenges such as low delivery efficiency, limited targeting ability, and suboptimal efficacy. With an aim of addressing these issues, engineering customized nanovaccines through modification or functionalization has emerged as a promising approach. These tailored nanovaccines not only enhance antigen presentation, but also effectively modulate immunosuppression within the tumor microenvironment. Specifically, they are distinguished by their diverse sizes, shapes, charges, structures, and unique physicochemical properties, along with targeting ligands. These features of nanovaccines facilitate lymph node accumulation and activation/regulation of immune cells. This overview of bespoke nanovaccines underscores their potential in both prophylactic and therapeutic applications, offering insights into their future development and role in cancer immunotherapy.http://www.sciencedirect.com/science/article/pii/S2452199X24000732NanovaccinesCustomized structureTailored-ligandEnhanced cancer immunotherapyProphylactic and therapeutic applications |
| spellingShingle | Jinyu Guo Changhua Liu Zhaoyang Qi Ting Qiu Jin Zhang Huanghao Yang Engineering customized nanovaccines for enhanced cancer immunotherapy Bioactive Materials Nanovaccines Customized structure Tailored-ligand Enhanced cancer immunotherapy Prophylactic and therapeutic applications |
| title | Engineering customized nanovaccines for enhanced cancer immunotherapy |
| title_full | Engineering customized nanovaccines for enhanced cancer immunotherapy |
| title_fullStr | Engineering customized nanovaccines for enhanced cancer immunotherapy |
| title_full_unstemmed | Engineering customized nanovaccines for enhanced cancer immunotherapy |
| title_short | Engineering customized nanovaccines for enhanced cancer immunotherapy |
| title_sort | engineering customized nanovaccines for enhanced cancer immunotherapy |
| topic | Nanovaccines Customized structure Tailored-ligand Enhanced cancer immunotherapy Prophylactic and therapeutic applications |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X24000732 |
| work_keys_str_mv | AT jinyuguo engineeringcustomizednanovaccinesforenhancedcancerimmunotherapy AT changhualiu engineeringcustomizednanovaccinesforenhancedcancerimmunotherapy AT zhaoyangqi engineeringcustomizednanovaccinesforenhancedcancerimmunotherapy AT tingqiu engineeringcustomizednanovaccinesforenhancedcancerimmunotherapy AT jinzhang engineeringcustomizednanovaccinesforenhancedcancerimmunotherapy AT huanghaoyang engineeringcustomizednanovaccinesforenhancedcancerimmunotherapy |