Hepatitis C: milestones from discovery to clinical cure
Abstract On October 5th, 2020, Drs. Harvey J. Alter, Michael Houghton and Charles M. Rice were rewarded with Nobel Prize in Physiology or Medicine for “the discovery of hepatitis C virus (HCV)”. During the past 50 years, remarkable achievements have been made in treatment of HCV infection: it has ch...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-12-01
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| Series: | Military Medical Research |
| Online Access: | https://doi.org/10.1186/s40779-020-00288-y |
| _version_ | 1818384405183332352 |
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| author | Wei Hu Chao Zhang Ji-Jing Shi Ji-Yuan Zhang Fu-Sheng Wang |
| author_facet | Wei Hu Chao Zhang Ji-Jing Shi Ji-Yuan Zhang Fu-Sheng Wang |
| author_sort | Wei Hu |
| collection | DOAJ |
| description | Abstract On October 5th, 2020, Drs. Harvey J. Alter, Michael Houghton and Charles M. Rice were rewarded with Nobel Prize in Physiology or Medicine for “the discovery of hepatitis C virus (HCV)”. During the past 50 years, remarkable achievements have been made in treatment of HCV infection: it has changed from being a life-threatening chronic disease to being curable. In this commentary, we briefly summarized the milestone events in the “scientific journey” from the first report of non-A, non-B hepatitis and discovery of the pathogen (HCV) to final identification of efficacious direct-acting antivirals. Further, we address the challenges and unmet issues in this field. |
| first_indexed | 2024-12-14T03:21:44Z |
| format | Article |
| id | doaj.art-1cf3caae89ea49c7b216f54b737d52e9 |
| institution | Directory Open Access Journal |
| issn | 2054-9369 |
| language | English |
| last_indexed | 2024-12-14T03:21:44Z |
| publishDate | 2020-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Military Medical Research |
| spelling | doaj.art-1cf3caae89ea49c7b216f54b737d52e92022-12-21T23:19:01ZengBMCMilitary Medical Research2054-93692020-12-01711310.1186/s40779-020-00288-yHepatitis C: milestones from discovery to clinical cureWei Hu0Chao Zhang1Ji-Jing Shi2Ji-Yuan Zhang3Fu-Sheng Wang4Medical School of Chinese PLADepartment of Infectious Diseases, the Fifth Medical Centre of Chinese PLA General Hospital, National Clinical Research Centre for Infectious DiseasesThe Central Laboratory, the First People’s Hospital of ZhengzhouMedical School of Chinese PLAMedical School of Chinese PLAAbstract On October 5th, 2020, Drs. Harvey J. Alter, Michael Houghton and Charles M. Rice were rewarded with Nobel Prize in Physiology or Medicine for “the discovery of hepatitis C virus (HCV)”. During the past 50 years, remarkable achievements have been made in treatment of HCV infection: it has changed from being a life-threatening chronic disease to being curable. In this commentary, we briefly summarized the milestone events in the “scientific journey” from the first report of non-A, non-B hepatitis and discovery of the pathogen (HCV) to final identification of efficacious direct-acting antivirals. Further, we address the challenges and unmet issues in this field.https://doi.org/10.1186/s40779-020-00288-y |
| spellingShingle | Wei Hu Chao Zhang Ji-Jing Shi Ji-Yuan Zhang Fu-Sheng Wang Hepatitis C: milestones from discovery to clinical cure Military Medical Research |
| title | Hepatitis C: milestones from discovery to clinical cure |
| title_full | Hepatitis C: milestones from discovery to clinical cure |
| title_fullStr | Hepatitis C: milestones from discovery to clinical cure |
| title_full_unstemmed | Hepatitis C: milestones from discovery to clinical cure |
| title_short | Hepatitis C: milestones from discovery to clinical cure |
| title_sort | hepatitis c milestones from discovery to clinical cure |
| url | https://doi.org/10.1186/s40779-020-00288-y |
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