Synthesis of new derivatives of hydrazinecarbothioamides and 1,2,4-triazoles and evaluation of their antimicrobial activities
A new series of hydrazinecarbothioamides 6-9 bearing 5H-dibenzo[a,d][7]annulene moiety were synthesized. Cyclization of 6-9 in NaOH solution produced the corresponding 1,2,4-triazoles-3(4H)-thiol 10-13, which proved to be axial isomers. The thioethers 14-17 were prepared by alkylation of...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Serbian Chemical Society
2015-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2015/0352-51391500039S.pdf |
| Summary: | A new series of hydrazinecarbothioamides 6-9 bearing
5H-dibenzo[a,d][7]annulene moiety were synthesized. Cyclization of 6-9 in
NaOH solution produced the corresponding 1,2,4-triazoles-3(4H)-thiol 10-13,
which proved to be axial isomers. The thioethers 14-17 were prepared by
alkylation of 10-13 with methyl iodide. All new compounds were characterized
by elemental analysis, IR-, UV-, 1H-NMR and 13C-NMR spectroscopy. The
evaluation for antimicrobial activity against Staphylococcus aureus ATCC
25923, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922,
Bacillus subtilis ATCC 6663, Salmonella tiphimurium ATCC 14028, Shigella
flexneri ATCC 12022, Candida albicans ATCC 90028 was performed. |
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| ISSN: | 0352-5139 1820-7421 |