Synthesis of new derivatives of hydrazinecarbothioamides and 1,2,4-triazoles and evaluation of their antimicrobial activities
A new series of hydrazinecarbothioamides 6-9 bearing 5H-dibenzo[a,d][7]annulene moiety were synthesized. Cyclization of 6-9 in NaOH solution produced the corresponding 1,2,4-triazoles-3(4H)-thiol 10-13, which proved to be axial isomers. The thioethers 14-17 were prepared by alkylation of...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2015-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2015/0352-51391500039S.pdf |
| _version_ | 1818485109862432768 |
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| author | Socea Laura I. Saramet Gabriel Draghici Constantin Socea Bogdan Constantin Vlad D. Radu-Popescu Manuela A. |
| author_facet | Socea Laura I. Saramet Gabriel Draghici Constantin Socea Bogdan Constantin Vlad D. Radu-Popescu Manuela A. |
| author_sort | Socea Laura I. |
| collection | DOAJ |
| description | A new series of hydrazinecarbothioamides 6-9 bearing
5H-dibenzo[a,d][7]annulene moiety were synthesized. Cyclization of 6-9 in
NaOH solution produced the corresponding 1,2,4-triazoles-3(4H)-thiol 10-13,
which proved to be axial isomers. The thioethers 14-17 were prepared by
alkylation of 10-13 with methyl iodide. All new compounds were characterized
by elemental analysis, IR-, UV-, 1H-NMR and 13C-NMR spectroscopy. The
evaluation for antimicrobial activity against Staphylococcus aureus ATCC
25923, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922,
Bacillus subtilis ATCC 6663, Salmonella tiphimurium ATCC 14028, Shigella
flexneri ATCC 12022, Candida albicans ATCC 90028 was performed. |
| first_indexed | 2024-12-10T16:04:06Z |
| format | Article |
| id | doaj.art-1cf4229445b542b8b3fcd2b39f5220bc |
| institution | Directory Open Access Journal |
| issn | 0352-5139 1820-7421 |
| language | English |
| last_indexed | 2024-12-10T16:04:06Z |
| publishDate | 2015-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-1cf4229445b542b8b3fcd2b39f5220bc2022-12-22T01:42:18ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51391820-74212015-01-0180121461147010.2298/JSC150227039S0352-51391500039SSynthesis of new derivatives of hydrazinecarbothioamides and 1,2,4-triazoles and evaluation of their antimicrobial activitiesSocea Laura I.0Saramet Gabriel1Draghici Constantin2Socea Bogdan3Constantin Vlad D.4Radu-Popescu Manuela A.5Carol Davila University of Medicine and Pharmacy, Faculty of Pharmacy, Organic Chemistry Department, Bucharest, Romania"Carol Davila" University of Medicine and Pharmacy, Faculty of Pharmacy, Pharmaceutical Technology Department, Bucharest, RomaniaRomanian Academy, "C.D. Nenitzescu" Institute of Organic Chemistry, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, Faculty of General Medicine, St. Pantelimon Emergency Hospital, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, Faculty of General Medicine, St. Pantelimon Emergency Hospital, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, Faculty of Pharmacy, General and Pharmaceutical Microbiology Department, Bucharest, RomaniaA new series of hydrazinecarbothioamides 6-9 bearing 5H-dibenzo[a,d][7]annulene moiety were synthesized. Cyclization of 6-9 in NaOH solution produced the corresponding 1,2,4-triazoles-3(4H)-thiol 10-13, which proved to be axial isomers. The thioethers 14-17 were prepared by alkylation of 10-13 with methyl iodide. All new compounds were characterized by elemental analysis, IR-, UV-, 1H-NMR and 13C-NMR spectroscopy. The evaluation for antimicrobial activity against Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922, Bacillus subtilis ATCC 6663, Salmonella tiphimurium ATCC 14028, Shigella flexneri ATCC 12022, Candida albicans ATCC 90028 was performed.http://www.doiserbia.nb.rs/img/doi/0352-5139/2015/0352-51391500039S.pdfacylhydrazinecarbothioamide1,2,4-triazol-3-thioledibenzo[a,d][7]annuleneantimicrobial activity |
| spellingShingle | Socea Laura I. Saramet Gabriel Draghici Constantin Socea Bogdan Constantin Vlad D. Radu-Popescu Manuela A. Synthesis of new derivatives of hydrazinecarbothioamides and 1,2,4-triazoles and evaluation of their antimicrobial activities Journal of the Serbian Chemical Society acylhydrazinecarbothioamide 1,2,4-triazol-3-thiole dibenzo[a,d][7]annulene antimicrobial activity |
| title | Synthesis of new derivatives of hydrazinecarbothioamides and 1,2,4-triazoles and evaluation of their antimicrobial activities |
| title_full | Synthesis of new derivatives of hydrazinecarbothioamides and 1,2,4-triazoles and evaluation of their antimicrobial activities |
| title_fullStr | Synthesis of new derivatives of hydrazinecarbothioamides and 1,2,4-triazoles and evaluation of their antimicrobial activities |
| title_full_unstemmed | Synthesis of new derivatives of hydrazinecarbothioamides and 1,2,4-triazoles and evaluation of their antimicrobial activities |
| title_short | Synthesis of new derivatives of hydrazinecarbothioamides and 1,2,4-triazoles and evaluation of their antimicrobial activities |
| title_sort | synthesis of new derivatives of hydrazinecarbothioamides and 1 2 4 triazoles and evaluation of their antimicrobial activities |
| topic | acylhydrazinecarbothioamide 1,2,4-triazol-3-thiole dibenzo[a,d][7]annulene antimicrobial activity |
| url | http://www.doiserbia.nb.rs/img/doi/0352-5139/2015/0352-51391500039S.pdf |
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