Transcriptional Regulation of Sphingosine Kinase 1
Once thought to be primarily structural in nature, sphingolipids have become increasingly appreciated as second messengers in a wide array of signaling pathways. Sphingosine kinase 1, or SK1, is one of two sphingosine kinases that phosphorylate sphingosine into sphingosine-1-phosphate (S1P). S1P is...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/11/2437 |
| _version_ | 1797548529497931776 |
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| author | Joseph Bonica Cungui Mao Lina M. Obeid Yusuf A. Hannun |
| author_facet | Joseph Bonica Cungui Mao Lina M. Obeid Yusuf A. Hannun |
| author_sort | Joseph Bonica |
| collection | DOAJ |
| description | Once thought to be primarily structural in nature, sphingolipids have become increasingly appreciated as second messengers in a wide array of signaling pathways. Sphingosine kinase 1, or SK1, is one of two sphingosine kinases that phosphorylate sphingosine into sphingosine-1-phosphate (S1P). S1P is generally pro-inflammatory, pro-angiogenic, immunomodulatory, and pro-survival; therefore, high SK1 expression and activity have been associated with certain inflammatory diseases and cancer. It is thus important to develop an understanding of the regulation of SK1 expression and activity. In this review, we explore the current literature on SK1 transcriptional regulation, illustrating a complex system of transcription factors, cytokines, and even micro-RNAs (miRNAs) on the post transcriptional level. |
| first_indexed | 2024-03-10T15:00:32Z |
| format | Article |
| id | doaj.art-1cf50c357eb240e2a505ac26f9efdb40 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T15:00:32Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-1cf50c357eb240e2a505ac26f9efdb402023-11-20T20:11:28ZengMDPI AGCells2073-44092020-11-01911243710.3390/cells9112437Transcriptional Regulation of Sphingosine Kinase 1Joseph Bonica0Cungui Mao1Lina M. Obeid2Yusuf A. Hannun3Department of Pharmacology, Stony Brook University, Stony Brook, NY 11794, USADepartment of Medicine, Stony Brook University, Stony Brook, NY 11794, USADepartment of Pharmacology, Stony Brook University, Stony Brook, NY 11794, USADepartment of Pharmacology, Stony Brook University, Stony Brook, NY 11794, USAOnce thought to be primarily structural in nature, sphingolipids have become increasingly appreciated as second messengers in a wide array of signaling pathways. Sphingosine kinase 1, or SK1, is one of two sphingosine kinases that phosphorylate sphingosine into sphingosine-1-phosphate (S1P). S1P is generally pro-inflammatory, pro-angiogenic, immunomodulatory, and pro-survival; therefore, high SK1 expression and activity have been associated with certain inflammatory diseases and cancer. It is thus important to develop an understanding of the regulation of SK1 expression and activity. In this review, we explore the current literature on SK1 transcriptional regulation, illustrating a complex system of transcription factors, cytokines, and even micro-RNAs (miRNAs) on the post transcriptional level.https://www.mdpi.com/2073-4409/9/11/2437sphingosine kinase 1SK1microRNAtranscription factorhypoxialong non-coding RNA |
| spellingShingle | Joseph Bonica Cungui Mao Lina M. Obeid Yusuf A. Hannun Transcriptional Regulation of Sphingosine Kinase 1 Cells sphingosine kinase 1 SK1 microRNA transcription factor hypoxia long non-coding RNA |
| title | Transcriptional Regulation of Sphingosine Kinase 1 |
| title_full | Transcriptional Regulation of Sphingosine Kinase 1 |
| title_fullStr | Transcriptional Regulation of Sphingosine Kinase 1 |
| title_full_unstemmed | Transcriptional Regulation of Sphingosine Kinase 1 |
| title_short | Transcriptional Regulation of Sphingosine Kinase 1 |
| title_sort | transcriptional regulation of sphingosine kinase 1 |
| topic | sphingosine kinase 1 SK1 microRNA transcription factor hypoxia long non-coding RNA |
| url | https://www.mdpi.com/2073-4409/9/11/2437 |
| work_keys_str_mv | AT josephbonica transcriptionalregulationofsphingosinekinase1 AT cunguimao transcriptionalregulationofsphingosinekinase1 AT linamobeid transcriptionalregulationofsphingosinekinase1 AT yusufahannun transcriptionalregulationofsphingosinekinase1 |