JNK signaling in pioneer neurons organizes ventral nerve cord architecture in Drosophila embryos

The shape and size of the mature central nervous system is highly regular, implying precise architectural rules. The authors show that alterations in JNK signaling in selected neurons impact the overall 3-dimensional organization of the Drosophila ventral nerve cord in a cell non-autonomous fashion.

Bibliographic Details
Main Authors: Katerina Karkali, Timothy E. Saunders, George Panayotou, Enrique Martín-Blanco
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36388-1
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author Katerina Karkali
Timothy E. Saunders
George Panayotou
Enrique Martín-Blanco
author_facet Katerina Karkali
Timothy E. Saunders
George Panayotou
Enrique Martín-Blanco
author_sort Katerina Karkali
collection DOAJ
description The shape and size of the mature central nervous system is highly regular, implying precise architectural rules. The authors show that alterations in JNK signaling in selected neurons impact the overall 3-dimensional organization of the Drosophila ventral nerve cord in a cell non-autonomous fashion.
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spelling doaj.art-1cf7f66382af4d7d85478b20b4b0f74c2023-02-12T12:16:35ZengNature PortfolioNature Communications2041-17232023-02-0114111610.1038/s41467-023-36388-1JNK signaling in pioneer neurons organizes ventral nerve cord architecture in Drosophila embryosKaterina Karkali0Timothy E. Saunders1George Panayotou2Enrique Martín-Blanco3Instituto de Biología Molecular de Barcelona (CSIC), Parc Cientific de BarcelonaMechanobiology Institute and Department of Biological Sciences, 5 Engineering Drive 1, National University of SingaporeBSRC Alexander FlemingInstituto de Biología Molecular de Barcelona (CSIC), Parc Cientific de BarcelonaThe shape and size of the mature central nervous system is highly regular, implying precise architectural rules. The authors show that alterations in JNK signaling in selected neurons impact the overall 3-dimensional organization of the Drosophila ventral nerve cord in a cell non-autonomous fashion.https://doi.org/10.1038/s41467-023-36388-1
spellingShingle Katerina Karkali
Timothy E. Saunders
George Panayotou
Enrique Martín-Blanco
JNK signaling in pioneer neurons organizes ventral nerve cord architecture in Drosophila embryos
Nature Communications
title JNK signaling in pioneer neurons organizes ventral nerve cord architecture in Drosophila embryos
title_full JNK signaling in pioneer neurons organizes ventral nerve cord architecture in Drosophila embryos
title_fullStr JNK signaling in pioneer neurons organizes ventral nerve cord architecture in Drosophila embryos
title_full_unstemmed JNK signaling in pioneer neurons organizes ventral nerve cord architecture in Drosophila embryos
title_short JNK signaling in pioneer neurons organizes ventral nerve cord architecture in Drosophila embryos
title_sort jnk signaling in pioneer neurons organizes ventral nerve cord architecture in drosophila embryos
url https://doi.org/10.1038/s41467-023-36388-1
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AT timothyesaunders jnksignalinginpioneerneuronsorganizesventralnervecordarchitectureindrosophilaembryos
AT georgepanayotou jnksignalinginpioneerneuronsorganizesventralnervecordarchitectureindrosophilaembryos
AT enriquemartinblanco jnksignalinginpioneerneuronsorganizesventralnervecordarchitectureindrosophilaembryos