Isolation of an Extract from the Soft Coral Symbiotic Microorganism <i>Salinispora arenicola</i> Exerting Cytoprotective and Anti-Aging Effects
Cells have developed a highly integrated system responsible for proteome stability, namely the proteostasis network (PN). As loss of proteostasis is a hallmark of aging and age-related diseases, the activation of PN modules can likely extend healthspan. Here, we present data on the bioactivity of an...
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MDPI AG
2021-12-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/44/1/2 |
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| author | Xanthippi P. Louka Aimilia D. Sklirou Géraldine Le Goff Philippe Lopes Eleni-Dimitra Papanagnou Maria S. Manola Yehuda Benayahu Jamal Ouazzani Ioannis P. Trougakos |
| author_facet | Xanthippi P. Louka Aimilia D. Sklirou Géraldine Le Goff Philippe Lopes Eleni-Dimitra Papanagnou Maria S. Manola Yehuda Benayahu Jamal Ouazzani Ioannis P. Trougakos |
| author_sort | Xanthippi P. Louka |
| collection | DOAJ |
| description | Cells have developed a highly integrated system responsible for proteome stability, namely the proteostasis network (PN). As loss of proteostasis is a hallmark of aging and age-related diseases, the activation of PN modules can likely extend healthspan. Here, we present data on the bioactivity of an extract (SA223-S2BM) purified from the strain <i>Salinispora arenicola</i> TM223-S2 that was isolated from the soft coral <i>Scleronephthya lewinsohni</i>; this coral was collected at a depth of 65 m from the mesophotic Red Sea ecosystem EAPC (south Eilat, Israel). Treatment of human cells with SA223-S2BM activated proteostatic modules, decreased oxidative load, and conferred protection against oxidative and genotoxic stress. Furthermore, SA223-S2BM enhanced proteasome and lysosomal-cathepsins activities in <i>Drosophila</i> flies and exhibited skin protective effects as evidenced by effective inhibition of the skin aging-related enzymes, elastase and tyrosinase. We suggest that the SA223-S2BM extract constitutes a likely promising source for prioritizing molecules with anti-aging properties. |
| first_indexed | 2024-03-10T01:42:00Z |
| format | Article |
| id | doaj.art-1cf8786b0b604cb98ce4ce26dd209f30 |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-10T01:42:00Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-1cf8786b0b604cb98ce4ce26dd209f302023-11-23T13:22:17ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452021-12-01441143010.3390/cimb44010002Isolation of an Extract from the Soft Coral Symbiotic Microorganism <i>Salinispora arenicola</i> Exerting Cytoprotective and Anti-Aging EffectsXanthippi P. Louka0Aimilia D. Sklirou1Géraldine Le Goff2Philippe Lopes3Eleni-Dimitra Papanagnou4Maria S. Manola5Yehuda Benayahu6Jamal Ouazzani7Ioannis P. Trougakos8Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, 15784 Athens, GreeceDepartment of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, 15784 Athens, GreeceCNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91190 Gif-sur-Yvette, FranceCNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91190 Gif-sur-Yvette, FranceDepartment of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, 15784 Athens, GreeceDepartment of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, 15784 Athens, GreeceSchool of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, IsraelCNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91190 Gif-sur-Yvette, FranceDepartment of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, 15784 Athens, GreeceCells have developed a highly integrated system responsible for proteome stability, namely the proteostasis network (PN). As loss of proteostasis is a hallmark of aging and age-related diseases, the activation of PN modules can likely extend healthspan. Here, we present data on the bioactivity of an extract (SA223-S2BM) purified from the strain <i>Salinispora arenicola</i> TM223-S2 that was isolated from the soft coral <i>Scleronephthya lewinsohni</i>; this coral was collected at a depth of 65 m from the mesophotic Red Sea ecosystem EAPC (south Eilat, Israel). Treatment of human cells with SA223-S2BM activated proteostatic modules, decreased oxidative load, and conferred protection against oxidative and genotoxic stress. Furthermore, SA223-S2BM enhanced proteasome and lysosomal-cathepsins activities in <i>Drosophila</i> flies and exhibited skin protective effects as evidenced by effective inhibition of the skin aging-related enzymes, elastase and tyrosinase. We suggest that the SA223-S2BM extract constitutes a likely promising source for prioritizing molecules with anti-aging properties.https://www.mdpi.com/1467-3045/44/1/2agingantioxidant responsesmarine microorganismproteostasis network<i>Salinispora arenicola</i> |
| spellingShingle | Xanthippi P. Louka Aimilia D. Sklirou Géraldine Le Goff Philippe Lopes Eleni-Dimitra Papanagnou Maria S. Manola Yehuda Benayahu Jamal Ouazzani Ioannis P. Trougakos Isolation of an Extract from the Soft Coral Symbiotic Microorganism <i>Salinispora arenicola</i> Exerting Cytoprotective and Anti-Aging Effects Current Issues in Molecular Biology aging antioxidant responses marine microorganism proteostasis network <i>Salinispora arenicola</i> |
| title | Isolation of an Extract from the Soft Coral Symbiotic Microorganism <i>Salinispora arenicola</i> Exerting Cytoprotective and Anti-Aging Effects |
| title_full | Isolation of an Extract from the Soft Coral Symbiotic Microorganism <i>Salinispora arenicola</i> Exerting Cytoprotective and Anti-Aging Effects |
| title_fullStr | Isolation of an Extract from the Soft Coral Symbiotic Microorganism <i>Salinispora arenicola</i> Exerting Cytoprotective and Anti-Aging Effects |
| title_full_unstemmed | Isolation of an Extract from the Soft Coral Symbiotic Microorganism <i>Salinispora arenicola</i> Exerting Cytoprotective and Anti-Aging Effects |
| title_short | Isolation of an Extract from the Soft Coral Symbiotic Microorganism <i>Salinispora arenicola</i> Exerting Cytoprotective and Anti-Aging Effects |
| title_sort | isolation of an extract from the soft coral symbiotic microorganism i salinispora arenicola i exerting cytoprotective and anti aging effects |
| topic | aging antioxidant responses marine microorganism proteostasis network <i>Salinispora arenicola</i> |
| url | https://www.mdpi.com/1467-3045/44/1/2 |
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