Synaptic components are required for glioblastoma progression in Drosophila.
Glioblastoma (GB) is the most aggressive, lethal and frequent primary brain tumor. It originates from glial cells and is characterized by rapid expansion through infiltration. GB cells interact with the microenvironment and healthy surrounding tissues, mostly neurons and vessels. GB cells project tu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-07-01
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| Series: | PLoS Genetics |
| Online Access: | https://doi.org/10.1371/journal.pgen.1010329 |
| _version_ | 1811284159193153536 |
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| author | María Losada-Pérez Mamen Hernández García-Moreno Irene García-Ricote Sergio Casas-Tintó |
| author_facet | María Losada-Pérez Mamen Hernández García-Moreno Irene García-Ricote Sergio Casas-Tintó |
| author_sort | María Losada-Pérez |
| collection | DOAJ |
| description | Glioblastoma (GB) is the most aggressive, lethal and frequent primary brain tumor. It originates from glial cells and is characterized by rapid expansion through infiltration. GB cells interact with the microenvironment and healthy surrounding tissues, mostly neurons and vessels. GB cells project tumor microtubes (TMs) contact with neurons, and exchange signaling molecules related to Wingless/WNT, JNK, Insulin or Neuroligin-3 pathways. This cell to cell communication promotes GB expansion and neurodegeneration. Moreover, healthy neurons form glutamatergic functional synapses with GB cells which facilitate GB expansion and premature death in mouse GB xerograph models. Targeting signaling and synaptic components of GB progression may become a suitable strategy against glioblastoma. In a Drosophila GB model, we have determined the post-synaptic nature of GB cells with respect to neurons, and the contribution of post-synaptic genes expressed in GB cells to tumor progression. In addition, we document the presence of intratumoral synapses between GB cells, and the functional contribution of pre-synaptic genes to GB calcium dependent activity and expansion. Finally, we explore the relevance of synaptic genes in GB cells to the lifespan reduction caused by GB advance. Our results indicate that both presynaptic and postsynaptic proteins play a role in GB progression and lethality. |
| first_indexed | 2024-04-13T02:24:31Z |
| format | Article |
| id | doaj.art-1cf9643a6c66476dba70cec1783c64df |
| institution | Directory Open Access Journal |
| issn | 1553-7390 1553-7404 |
| language | English |
| last_indexed | 2024-04-13T02:24:31Z |
| publishDate | 2022-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj.art-1cf9643a6c66476dba70cec1783c64df2022-12-22T03:06:49ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042022-07-01187e101032910.1371/journal.pgen.1010329Synaptic components are required for glioblastoma progression in Drosophila.María Losada-PérezMamen Hernández García-MorenoIrene García-RicoteSergio Casas-TintóGlioblastoma (GB) is the most aggressive, lethal and frequent primary brain tumor. It originates from glial cells and is characterized by rapid expansion through infiltration. GB cells interact with the microenvironment and healthy surrounding tissues, mostly neurons and vessels. GB cells project tumor microtubes (TMs) contact with neurons, and exchange signaling molecules related to Wingless/WNT, JNK, Insulin or Neuroligin-3 pathways. This cell to cell communication promotes GB expansion and neurodegeneration. Moreover, healthy neurons form glutamatergic functional synapses with GB cells which facilitate GB expansion and premature death in mouse GB xerograph models. Targeting signaling and synaptic components of GB progression may become a suitable strategy against glioblastoma. In a Drosophila GB model, we have determined the post-synaptic nature of GB cells with respect to neurons, and the contribution of post-synaptic genes expressed in GB cells to tumor progression. In addition, we document the presence of intratumoral synapses between GB cells, and the functional contribution of pre-synaptic genes to GB calcium dependent activity and expansion. Finally, we explore the relevance of synaptic genes in GB cells to the lifespan reduction caused by GB advance. Our results indicate that both presynaptic and postsynaptic proteins play a role in GB progression and lethality.https://doi.org/10.1371/journal.pgen.1010329 |
| spellingShingle | María Losada-Pérez Mamen Hernández García-Moreno Irene García-Ricote Sergio Casas-Tintó Synaptic components are required for glioblastoma progression in Drosophila. PLoS Genetics |
| title | Synaptic components are required for glioblastoma progression in Drosophila. |
| title_full | Synaptic components are required for glioblastoma progression in Drosophila. |
| title_fullStr | Synaptic components are required for glioblastoma progression in Drosophila. |
| title_full_unstemmed | Synaptic components are required for glioblastoma progression in Drosophila. |
| title_short | Synaptic components are required for glioblastoma progression in Drosophila. |
| title_sort | synaptic components are required for glioblastoma progression in drosophila |
| url | https://doi.org/10.1371/journal.pgen.1010329 |
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