Monitoring genomic sequences during SELEX using high-throughput sequencing: neutral SELEX.
BACKGROUND: SELEX is a well established in vitro selection tool to analyze the structure of ligand-binding nucleic acid sequences called aptamers. Genomic SELEX transforms SELEX into a tool to discover novel, genomically encoded RNA or DNA sequences binding a ligand of interest, called genomic aptam...
Main Authors: | Bob Zimmermann, Tanja Gesell, Doris Chen, Christina Lorenz, Renée Schroeder |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2820082?pdf=render |
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