Reactivity of vitamin A derivatives and analogues with vitamin A antibodies.
Vitamin A antibodies were obtained using retinoic acid conjugated to human serum albumin as an immunogen. The following constraints governed the reactivity of vitamin A analogues with such an anti-serum. The stereochemistry of the side chain is relatively unimportant, and 9- and 13-cis retinal react...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
1981-07-01
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| Series: | Journal of Lipid Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520373594 |
| _version_ | 1818459743225643008 |
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| author | G H Wirtz S S Westfall |
| author_facet | G H Wirtz S S Westfall |
| author_sort | G H Wirtz |
| collection | DOAJ |
| description | Vitamin A antibodies were obtained using retinoic acid conjugated to human serum albumin as an immunogen. The following constraints governed the reactivity of vitamin A analogues with such an anti-serum. The stereochemistry of the side chain is relatively unimportant, and 9- and 13-cis retinal react almost as well as all-trans retinal. The nature of the ring is important; all of the compounds that react readily carry a beta-ionic ring; all of the compounds bearing an aromatic ring react poorly; the two compounds that display intermediate reactivity have non-aromatic 6- and 5-membered rings, respectively. |
| first_indexed | 2024-12-14T23:19:12Z |
| format | Article |
| id | doaj.art-1cfdaf7cd4b148359f1b16683a3f7b7e |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-14T23:19:12Z |
| publishDate | 1981-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-1cfdaf7cd4b148359f1b16683a3f7b7e2022-12-21T22:44:00ZengElsevierJournal of Lipid Research0022-22751981-07-01225869871Reactivity of vitamin A derivatives and analogues with vitamin A antibodies.G H WirtzS S WestfallVitamin A antibodies were obtained using retinoic acid conjugated to human serum albumin as an immunogen. The following constraints governed the reactivity of vitamin A analogues with such an anti-serum. The stereochemistry of the side chain is relatively unimportant, and 9- and 13-cis retinal react almost as well as all-trans retinal. The nature of the ring is important; all of the compounds that react readily carry a beta-ionic ring; all of the compounds bearing an aromatic ring react poorly; the two compounds that display intermediate reactivity have non-aromatic 6- and 5-membered rings, respectively.http://www.sciencedirect.com/science/article/pii/S0022227520373594 |
| spellingShingle | G H Wirtz S S Westfall Reactivity of vitamin A derivatives and analogues with vitamin A antibodies. Journal of Lipid Research |
| title | Reactivity of vitamin A derivatives and analogues with vitamin A antibodies. |
| title_full | Reactivity of vitamin A derivatives and analogues with vitamin A antibodies. |
| title_fullStr | Reactivity of vitamin A derivatives and analogues with vitamin A antibodies. |
| title_full_unstemmed | Reactivity of vitamin A derivatives and analogues with vitamin A antibodies. |
| title_short | Reactivity of vitamin A derivatives and analogues with vitamin A antibodies. |
| title_sort | reactivity of vitamin a derivatives and analogues with vitamin a antibodies |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520373594 |
| work_keys_str_mv | AT ghwirtz reactivityofvitaminaderivativesandanalogueswithvitaminaantibodies AT sswestfall reactivityofvitaminaderivativesandanalogueswithvitaminaantibodies |