Identification of a natural human serotype 3 parainfluenza virus
<p>Abstract</p> <p>Parainfluenza virus is an important pathogen threatening the health of animals and human, which brings human many kinds of disease, especially lower respiratory tract infection involving infants and young children. In order to control the virus, it is necessary t...
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Format: | Article |
Language: | English |
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BMC
2011-02-01
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Series: | Virology Journal |
Online Access: | http://www.virologyj.com/content/8/1/58 |
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author | Wang Xiao-Jing Si Hong-Li Bai Mu-Qun Zhou Xu Jiang Qing Yang Hui-Ting Lu Yan Zhao Heng He Hong-Bin He Cheng-Qiang |
author_facet | Wang Xiao-Jing Si Hong-Li Bai Mu-Qun Zhou Xu Jiang Qing Yang Hui-Ting Lu Yan Zhao Heng He Hong-Bin He Cheng-Qiang |
author_sort | Wang Xiao-Jing |
collection | DOAJ |
description | <p>Abstract</p> <p>Parainfluenza virus is an important pathogen threatening the health of animals and human, which brings human many kinds of disease, especially lower respiratory tract infection involving infants and young children. In order to control the virus, it is necessary to fully understand the molecular basis resulting in the genetic diversity of the virus. Homologous recombination is one of mechanisms for the rapid change of genetic diversity. However, as a negative-strand virus, it is unknown whether the recombination can naturally take place in human PIV. In this study, we isolated and identified a mosaic serotype 3 human PIV (HPIV3) from in China, and also provided several putative PIV mosaics from previous reports to reveal that the recombination can naturally occur in the virus. In addition, two swine PIV3 isolates transferred from cattle to pigs were found to have mosaic genomes. These results suggest that homologous recombination can promote the genetic diversity and potentially bring some novel biologic characteristics of HPIV.</p> |
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format | Article |
id | doaj.art-1d008a409961496196a4323ff7fe29a8 |
institution | Directory Open Access Journal |
issn | 1743-422X |
language | English |
last_indexed | 2024-04-12T16:13:25Z |
publishDate | 2011-02-01 |
publisher | BMC |
record_format | Article |
series | Virology Journal |
spelling | doaj.art-1d008a409961496196a4323ff7fe29a82022-12-22T03:25:50ZengBMCVirology Journal1743-422X2011-02-01815810.1186/1743-422X-8-58Identification of a natural human serotype 3 parainfluenza virusWang Xiao-JingSi Hong-LiBai Mu-QunZhou XuJiang QingYang Hui-TingLu YanZhao HengHe Hong-BinHe Cheng-Qiang<p>Abstract</p> <p>Parainfluenza virus is an important pathogen threatening the health of animals and human, which brings human many kinds of disease, especially lower respiratory tract infection involving infants and young children. In order to control the virus, it is necessary to fully understand the molecular basis resulting in the genetic diversity of the virus. Homologous recombination is one of mechanisms for the rapid change of genetic diversity. However, as a negative-strand virus, it is unknown whether the recombination can naturally take place in human PIV. In this study, we isolated and identified a mosaic serotype 3 human PIV (HPIV3) from in China, and also provided several putative PIV mosaics from previous reports to reveal that the recombination can naturally occur in the virus. In addition, two swine PIV3 isolates transferred from cattle to pigs were found to have mosaic genomes. These results suggest that homologous recombination can promote the genetic diversity and potentially bring some novel biologic characteristics of HPIV.</p>http://www.virologyj.com/content/8/1/58 |
spellingShingle | Wang Xiao-Jing Si Hong-Li Bai Mu-Qun Zhou Xu Jiang Qing Yang Hui-Ting Lu Yan Zhao Heng He Hong-Bin He Cheng-Qiang Identification of a natural human serotype 3 parainfluenza virus Virology Journal |
title | Identification of a natural human serotype 3 parainfluenza virus |
title_full | Identification of a natural human serotype 3 parainfluenza virus |
title_fullStr | Identification of a natural human serotype 3 parainfluenza virus |
title_full_unstemmed | Identification of a natural human serotype 3 parainfluenza virus |
title_short | Identification of a natural human serotype 3 parainfluenza virus |
title_sort | identification of a natural human serotype 3 parainfluenza virus |
url | http://www.virologyj.com/content/8/1/58 |
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