Similarities and Differences in the Pattern of Tau Hyperphosphorylation in Physiological and Pathological Conditions: Impacts on the Elaboration of Therapies to Prevent Tau Pathology

Similarities and Differences in the Pattern of Tau Hyperphosphorylation in Physiological and Pathological Conditions: Impacts on the Elaboration of Therapies to Prevent Tau Pathology

Tau protein, a neuronal microtubule-associated protein, becomes hyperphosphorylated in several neurodegenerative diseases called tauopathies. Hyperphosphorylation of tau is correlated to its redistribution from the axon to the somato-dendritic compartment at early stages of tauopathies. Interestingl...

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Bibliographic Details
Main Authors: Antoine Duquette, Camille Pernègre, Ariane Veilleux Carpentier, Nicole Leclerc
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Neurology
Subjects:
tau protein
hyperphosphorylation
tauopathies
microtubules
Alzheimer's disease
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2020.607680/full

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