In Vivo Production of RNA Aptamers and Nanoparticles: Problems and Prospects
RNA aptamers are becoming increasingly attractive due to their superior properties. This review discusses the early stages of aptamer research, the main developments in this area, and the latest technologies being developed. The review also highlights the advantages of RNA aptamers in comparison to...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-03-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/5/1422 |
| _version_ | 1797413275501068288 |
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| author | Ousama Al Shanaa Andrey Rumyantsev Elena Sambuk Marina Padkina |
| author_facet | Ousama Al Shanaa Andrey Rumyantsev Elena Sambuk Marina Padkina |
| author_sort | Ousama Al Shanaa |
| collection | DOAJ |
| description | RNA aptamers are becoming increasingly attractive due to their superior properties. This review discusses the early stages of aptamer research, the main developments in this area, and the latest technologies being developed. The review also highlights the advantages of RNA aptamers in comparison to antibodies, considering the great potential of RNA aptamers and their applications in the near future. In addition, it is shown how RNA aptamers can form endless 3-D structures, giving rise to various structural and functional possibilities. Special attention is paid to the Mango, Spinach and Broccoli fluorescent RNA aptamers, and the advantages of split RNA aptamers are discussed. The review focuses on the importance of creating a platform for the synthesis of RNA nanoparticles in vivo and examines yeast, namely <i>Saccharomyces cerevisiae</i>, as a potential model organism for the production of RNA nanoparticles on a large scale. |
| first_indexed | 2024-03-09T05:14:43Z |
| format | Article |
| id | doaj.art-1d05ee41ce234c1fbcd1dd665739d6d2 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T05:14:43Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1d05ee41ce234c1fbcd1dd665739d6d22023-12-03T12:46:06ZengMDPI AGMolecules1420-30492021-03-01265142210.3390/molecules26051422In Vivo Production of RNA Aptamers and Nanoparticles: Problems and ProspectsOusama Al Shanaa0Andrey Rumyantsev1Elena Sambuk2Marina Padkina3Department of Genetics and Biotechnology, Saint Petersburg State University, 199034 Saint Petersburg, RussiaDepartment of Genetics and Biotechnology, Saint Petersburg State University, 199034 Saint Petersburg, RussiaDepartment of Genetics and Biotechnology, Saint Petersburg State University, 199034 Saint Petersburg, RussiaDepartment of Genetics and Biotechnology, Saint Petersburg State University, 199034 Saint Petersburg, RussiaRNA aptamers are becoming increasingly attractive due to their superior properties. This review discusses the early stages of aptamer research, the main developments in this area, and the latest technologies being developed. The review also highlights the advantages of RNA aptamers in comparison to antibodies, considering the great potential of RNA aptamers and their applications in the near future. In addition, it is shown how RNA aptamers can form endless 3-D structures, giving rise to various structural and functional possibilities. Special attention is paid to the Mango, Spinach and Broccoli fluorescent RNA aptamers, and the advantages of split RNA aptamers are discussed. The review focuses on the importance of creating a platform for the synthesis of RNA nanoparticles in vivo and examines yeast, namely <i>Saccharomyces cerevisiae</i>, as a potential model organism for the production of RNA nanoparticles on a large scale.https://www.mdpi.com/1420-3049/26/5/1422aptamernanoparticlesnucleic acidsnucleic acid nanoparticles |
| spellingShingle | Ousama Al Shanaa Andrey Rumyantsev Elena Sambuk Marina Padkina In Vivo Production of RNA Aptamers and Nanoparticles: Problems and Prospects Molecules aptamer nanoparticles nucleic acids nucleic acid nanoparticles |
| title | In Vivo Production of RNA Aptamers and Nanoparticles: Problems and Prospects |
| title_full | In Vivo Production of RNA Aptamers and Nanoparticles: Problems and Prospects |
| title_fullStr | In Vivo Production of RNA Aptamers and Nanoparticles: Problems and Prospects |
| title_full_unstemmed | In Vivo Production of RNA Aptamers and Nanoparticles: Problems and Prospects |
| title_short | In Vivo Production of RNA Aptamers and Nanoparticles: Problems and Prospects |
| title_sort | in vivo production of rna aptamers and nanoparticles problems and prospects |
| topic | aptamer nanoparticles nucleic acids nucleic acid nanoparticles |
| url | https://www.mdpi.com/1420-3049/26/5/1422 |
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