Association of common variant rs9934336 of SLC5A2 (SGLT2) gene with SARS-CoV-2 infection and mortality
Abstract COVID-19 has its life-threatening complications more pronounced in people with underlying health conditions such as diabetes, cardiovascular disease and kidney disease. Inhibition of the sodiumglucose cotransporter 2 (SGLT2), which primarily increases urinary glucose excretion, is shown to...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-01-01
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| Series: | Egyptian Journal of Medical Human Genetics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43042-024-00481-x |
| _version_ | 1797276453294833664 |
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| author | Anamika Das Gunanidhi Dhangadamajhi |
| author_facet | Anamika Das Gunanidhi Dhangadamajhi |
| author_sort | Anamika Das |
| collection | DOAJ |
| description | Abstract COVID-19 has its life-threatening complications more pronounced in people with underlying health conditions such as diabetes, cardiovascular disease and kidney disease. Inhibition of the sodiumglucose cotransporter 2 (SGLT2), which primarily increases urinary glucose excretion, is shown to be beneficial in patients with type 2 diabetes mellitus (T2D) and other comorbidities. SGLT2 is encoded by SLC5A2 gene, and of the several genetic variants, SNP rs9934336 is gaining importance for being associated with reduced HbA1c level and lower incidence of T2D. Since a complex bidirectional relationship exists between COVID-19 and hyperglycaemia, we conducted a worldwide association study to investigate the effect of rs9934336 on COVID-19 outcomes. Worldwide prevalence data of SLC5A2 SNP rs9934336 were obtained from relevant published articles and databases for genomic variants. COVID-19 data procured from the Worldometer website were used for conducting Spearman’s correlation analysis with minor allele frequency data of rs9934336. Significant positive correlation was observed between rs9934336 and COVID-19 incidence (p < 0.0001, r = 0.6225) as well as deaths (p < 0.0001, r = 0.5837). The present finding of significant association of SLC5A2 variant rs9934336 with COVID-19 risk has to be validated by case–control studies in diverse populations along with other variants regulating the expression and function of SGLT2. |
| first_indexed | 2024-03-07T15:28:27Z |
| format | Article |
| id | doaj.art-1d063eac52824e8da8097ed33084e6b4 |
| institution | Directory Open Access Journal |
| issn | 2090-2441 |
| language | English |
| last_indexed | 2024-03-07T15:28:27Z |
| publishDate | 2024-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Journal of Medical Human Genetics |
| spelling | doaj.art-1d063eac52824e8da8097ed33084e6b42024-03-05T16:31:53ZengSpringerOpenEgyptian Journal of Medical Human Genetics2090-24412024-01-012511710.1186/s43042-024-00481-xAssociation of common variant rs9934336 of SLC5A2 (SGLT2) gene with SARS-CoV-2 infection and mortalityAnamika Das0Gunanidhi Dhangadamajhi1Independent ResearcherDepartment of Biotechnology, Maharaja Sriram Chandra Bhanjadeo UniversityAbstract COVID-19 has its life-threatening complications more pronounced in people with underlying health conditions such as diabetes, cardiovascular disease and kidney disease. Inhibition of the sodiumglucose cotransporter 2 (SGLT2), which primarily increases urinary glucose excretion, is shown to be beneficial in patients with type 2 diabetes mellitus (T2D) and other comorbidities. SGLT2 is encoded by SLC5A2 gene, and of the several genetic variants, SNP rs9934336 is gaining importance for being associated with reduced HbA1c level and lower incidence of T2D. Since a complex bidirectional relationship exists between COVID-19 and hyperglycaemia, we conducted a worldwide association study to investigate the effect of rs9934336 on COVID-19 outcomes. Worldwide prevalence data of SLC5A2 SNP rs9934336 were obtained from relevant published articles and databases for genomic variants. COVID-19 data procured from the Worldometer website were used for conducting Spearman’s correlation analysis with minor allele frequency data of rs9934336. Significant positive correlation was observed between rs9934336 and COVID-19 incidence (p < 0.0001, r = 0.6225) as well as deaths (p < 0.0001, r = 0.5837). The present finding of significant association of SLC5A2 variant rs9934336 with COVID-19 risk has to be validated by case–control studies in diverse populations along with other variants regulating the expression and function of SGLT2.https://doi.org/10.1186/s43042-024-00481-xCOVID-19SLC5A2 geners9934336Type 2 diabetesSodium–glucose cotransporter 2Sodium–glucose cotransporter 2 inhibitor |
| spellingShingle | Anamika Das Gunanidhi Dhangadamajhi Association of common variant rs9934336 of SLC5A2 (SGLT2) gene with SARS-CoV-2 infection and mortality Egyptian Journal of Medical Human Genetics COVID-19 SLC5A2 gene rs9934336 Type 2 diabetes Sodium–glucose cotransporter 2 Sodium–glucose cotransporter 2 inhibitor |
| title | Association of common variant rs9934336 of SLC5A2 (SGLT2) gene with SARS-CoV-2 infection and mortality |
| title_full | Association of common variant rs9934336 of SLC5A2 (SGLT2) gene with SARS-CoV-2 infection and mortality |
| title_fullStr | Association of common variant rs9934336 of SLC5A2 (SGLT2) gene with SARS-CoV-2 infection and mortality |
| title_full_unstemmed | Association of common variant rs9934336 of SLC5A2 (SGLT2) gene with SARS-CoV-2 infection and mortality |
| title_short | Association of common variant rs9934336 of SLC5A2 (SGLT2) gene with SARS-CoV-2 infection and mortality |
| title_sort | association of common variant rs9934336 of slc5a2 sglt2 gene with sars cov 2 infection and mortality |
| topic | COVID-19 SLC5A2 gene rs9934336 Type 2 diabetes Sodium–glucose cotransporter 2 Sodium–glucose cotransporter 2 inhibitor |
| url | https://doi.org/10.1186/s43042-024-00481-x |
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